Urinary concentrating defect in mice lacking Epac1 or Epac2.

Animals Aquaporin 2 / metabolism Arginine Vasopressin / metabolism Calcium Signaling Diuresis Gene Deletion Guanine Nucleotide Exchange Factors / genetics Kidney / metabolism Kidney Concentrating Ability / genetics Mice Mice, Knockout Osmosis Polyuria / genetics Sodium-Hydrogen Exchanger 3 / metabolism
AQP2 NHE-3 collecting duct urea water deprivation

Journal

FASEB journal : official publication of the Federation of American Societies for Experimental Biology
ISSN: 1530-6860
Titre abrégé: FASEB J
Pays: United States
ID NLM: 8804484

Informations de publication

Date de publication:
02 2019
Historique:
pubmed: 27 9 2018
medline: 1 10 2019
entrez: 26 9 2018
Statut: ppublish

Résumé

cAMP is a universal second messenger regulating a plethora of processes in the kidney. Two downstream effectors of cAMP are PKA and exchange protein directly activated by cAMP (Epac), which, unlike PKA, is often linked to elevation of [Ca

Identifiants

DOI: 10.1096/fj.201800435R PMID: 30252533 PMC: PMC6338637
pubmed: 30252533
doi: 10.1096/fj.201800435R
pmc: PMC6338637
doi:

Substances chimiques

Aqp2 protein, mouse 0
Aquaporin 2 0
Epac protein, mouse 0
Guanine Nucleotide Exchange Factors 0
Rapgef4 protein, mouse 0
Slc9a3 protein, mouse 0
Sodium-Hydrogen Exchanger 3 0
Arginine Vasopressin 113-79-1

Types de publication

Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

2156-2170

Subventions

Organisme : NIDDK NIH HHS
ID : R01 DK095029
Pays : United States
Organisme : NIDDK NIH HHS
ID : R01 DK107263
Pays : United States
Organisme : NIGMS NIH HHS
ID : R01 GM066170
Pays : United States
Organisme : NIGMS NIH HHS
ID : R35 GM122536
Pays : United States

Références

Am J Physiol Gastrointest Liver Physiol. 2009 Apr;296(4):G886-98
pubmed: 19164484
Clin J Am Soc Nephrol. 2014 Nov 7;9(11):1974-86
pubmed: 25318757
Am J Physiol. 1997 Apr;272(4 Pt 2):F443-50
pubmed: 9140044
J Biol Chem. 2003 Jul 18;278(29):26946-51
pubmed: 12732642
Annu Rev Pharmacol Toxicol. 2010;50:355-75
pubmed: 20055708
Circ Res. 2005 Dec 9;97(12):1296-304
pubmed: 16269655
Kidney Int. 2017 Aug;92(2):397-414
pubmed: 28385297
J Am Soc Nephrol. 2013 Mar;24(4):604-16
pubmed: 23411787
J Am Soc Nephrol. 2009 Sep;20(9):2018-24
pubmed: 19661162
J Exp Biol. 2009 Jun;212(Pt 11):1638-46
pubmed: 19448074
J Biol Chem. 2013 Jul 12;288(28):20306-14
pubmed: 23709216
J Biol Chem. 2000 Oct 13;275(41):31601-8
pubmed: 10866993
J Biol Chem. 2000 Nov 24;275(47):36839-46
pubmed: 10973964
Am J Physiol Renal Physiol. 2008 Oct;295(4):F1003-16
pubmed: 18653479
J Am Soc Nephrol. 1997 Jun;8(6):861-7
pubmed: 9189851
Hypertension. 2012 Nov;60(5):1234-41
pubmed: 23033373
Am J Physiol Renal Physiol. 2000 Jan;278(1):F52-62
pubmed: 10644655
J Biol Chem. 2004 Sep 3;279(36):37815-21
pubmed: 15218020
Methods Mol Biol. 2013;998:371-84
pubmed: 23529445
Exp Neurol. 2001 Oct;171(2):227-34
pubmed: 11573975
J Biol Chem. 2012 Mar 16;287(12):8782-91
pubmed: 22298783
Science. 1998 Dec 18;282(5397):2275-9
pubmed: 9856955
Clin J Am Soc Nephrol. 2015 Apr 7;10(4):676-87
pubmed: 25098598
Kidney Int. 2010 Jul;78(2):160-9
pubmed: 20445498
Proc Natl Acad Sci U S A. 2006 Jan 17;103(3):803-8
pubmed: 16407144
J Physiol. 2002 Feb 1;538(Pt 3):891-9
pubmed: 11826172
Mol Pharmacol. 2013 Jan;83(1):122-8
pubmed: 23066090
N Engl J Med. 2015 Apr 2;372(14):1349-58
pubmed: 25830425
Am J Physiol Renal Physiol. 2011 Feb;300(2):F540-8
pubmed: 21147839
Pflugers Arch. 2009 Mar;457(5):1079-91
pubmed: 18758809
Pflugers Arch. 2008 Jul;456(4):747-54
pubmed: 17957381
Nat Genet. 1998 Jul;19(3):282-5
pubmed: 9662405
Am J Physiol Renal Physiol. 2015 Jul 15;309(2):F146-53
pubmed: 25995110
Sci Rep. 2015 Mar 20;5:9344
pubmed: 25791905
Kidney Int. 2001 Jan;59(1):197-209
pubmed: 11135072
J Am Soc Nephrol. 2016 May;27(5):1448-55
pubmed: 26407594
J Biol Chem. 1985 Mar 25;260(6):3440-50
pubmed: 3838314
Am J Physiol Renal Physiol. 2006 Oct;291(4):F882-90
pubmed: 16684923
Circ Res. 2016 Mar 4;118(5):881-97
pubmed: 26941424
Nat Cell Biol. 2002 Nov;4(11):901-6
pubmed: 12402047
Am J Physiol Renal Physiol. 2008 Aug;295(2):F525-33
pubmed: 18495799
Mol Cell Biol. 2013 Mar;33(5):918-26
pubmed: 23263987
J Physiol. 2006 Nov 15;577(Pt 1):5-15
pubmed: 16973695
Circulation. 2013 Feb 26;127(8):913-22
pubmed: 23363625
Physiol Rev. 2018 Apr 1;98(2):919-1053
pubmed: 29537337
Clin Exp Nephrol. 2013 Dec;17(6):751-64
pubmed: 23584881
Mol Cell Biol. 2005 Aug;25(16):7357-63
pubmed: 16055743
Am J Physiol. 1996 Apr;270(4 Pt 2):F691-9
pubmed: 8967348
J Cell Sci. 2016 Jul 1;129(13):2599-612
pubmed: 27206858
Pharmacol Rev. 2013 Feb 27;65(2):670-709
pubmed: 23447132
Compr Physiol. 2011 Apr;1(2):699-729
pubmed: 23737200
Nature. 1998 Dec 3;396(6710):474-7
pubmed: 9853756
J Am Soc Nephrol. 2016 Jul;27(7):2035-48
pubmed: 26574044
Proc Natl Acad Sci U S A. 2012 Nov 6;109(45):18613-8
pubmed: 23091014
J Biol Chem. 2003 Mar 7;278(10):8279-85
pubmed: 12496249
J Biol Chem. 1997 Jun 6;272(23):14800-4
pubmed: 9169447
Am J Physiol Cell Physiol. 2007 May;292(5):C1606-16
pubmed: 17166937
Clin J Am Soc Nephrol. 2015 May 7;10(5):852-62
pubmed: 25078421
Bioorg Med Chem Lett. 2017 Apr 15;27(8):1633-1639
pubmed: 28283242
Am J Physiol Renal Physiol. 2012 Jun 1;302(11):F1395-401
pubmed: 22419689
Proc Natl Acad Sci U S A. 2010 Feb 23;107(8):3882-7
pubmed: 20139300
J Biol Chem. 2009 Sep 11;284(37):24965-71
pubmed: 19592485
Nat Rev Nephrol. 2015 Oct;11(10):576-88
pubmed: 26077742
Gene. 2015 Oct 10;570(2):157-67
pubmed: 26119090

Auteurs

Alena Cherezova (A)

Department of Physiology, Medical College of Georgia, Augusta University, Augusta, Georgia, USA.

Viktor Tomilin (V)

Department of Integrative Biology and Pharmacology The University of Texas Health Science Center at Houston, Houston, Texas, USA.

Vadym Buncha (V)

Department of Physiology, Medical College of Georgia, Augusta University, Augusta, Georgia, USA.

Oleg Zaika (O)

Department of Integrative Biology and Pharmacology The University of Texas Health Science Center at Houston, Houston, Texas, USA.

Pablo A Ortiz (PA)

Hypertension and Vascular Research Division, Department of Internal Medicine, Henry Ford Hospital, Detroit, Michigan, USA; and.

Fang Mei (F)

Department of Integrative Biology and Pharmacology The University of Texas Health Science Center at Houston, Houston, Texas, USA.

Xiaodong Cheng (X)

Department of Integrative Biology and Pharmacology The University of Texas Health Science Center at Houston, Houston, Texas, USA.
Texas Therapeutics Institute, The University of Texas Health Science Center at Houston, Houston, Texas, USA.

Mykola Mamenko (M)

Department of Physiology, Medical College of Georgia, Augusta University, Augusta, Georgia, USA.

Oleh Pochynyuk (O)

Department of Integrative Biology and Pharmacology The University of Texas Health Science Center at Houston, Houston, Texas, USA.

Articles similaires

Evaluating the efficacy of telesurgery with dual console SSI Mantra Surgical Robotic System: experiment on animal model and clinical trials.

Sudhir Prem Srivastava, Vishwajyoti Pascual Srivastava, Avinesh Singh et al.
1.00
Robotic Surgical Procedures Animals Humans Telemedicine Models, Animal

Odour generalisation and detection dog training.

Lyn Caldicott, Thomas W Pike, Helen E Zulch et al.
1.00
Animals Odorants Dogs Generalization, Psychological Smell

FBXO22 inhibits colitis and colorectal carcinogenesis by regulating the degradation of the S2448-phosphorylated form of mTOR.

Minle Li, Xuan Chen, Pengfei Qu et al.
1.00
Animals TOR Serine-Threonine Kinases Colorectal Neoplasms Colitis Mice

Use of organic material provided by an automatic enrichment device by weaner pigs and its influence on tail lesions.

Philipp Heseker, Jeanette Probst, Stefanie Ammer et al.
1.00
Animals Tail Swine Behavior, Animal Animal Husbandry

Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Urinary concentrating defect in mice lacking...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Protéines de transport membranaire › Canaux ioniques › Porines › Aquaporines › Aquaporine-2 › Urinary concentrating defect in mice lacking...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines de tissu nerveux › Neuropeptides › Vasopressines › Arginine vasopressine › Urinary concentrating defect in mice lacking...
questionsmedicales.fr › Phénomènes physiologiques cellulaires › Transduction du signal › Systèmes de seconds messagers › Signalisation calcique › Urinary concentrating defect in mice lacking...
questionsmedicales.fr › Phénomènes physiologiques des appareils urinaire et reproducteur › Phénomènes physiologiques des voies urinaires › Diurèse › Urinary concentrating defect in mice lacking...
questionsmedicales.fr › Phénomènes génétiques › Mutagenèse › Délétion de séquence › Délétion de gène › Urinary concentrating defect in mice lacking...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines et peptides de signalisation intracellulaire › Régulateurs des protéines G › Facteurs d'échange de nucléotides guanyliques › Urinary concentrating defect in mice lacking...
questionsmedicales.fr › Appareil urogénital › Voies urinaires › Rein › Urinary concentrating defect in mice lacking...
questionsmedicales.fr › Phénomènes physiologiques des appareils urinaire et reproducteur › Phénomènes physiologiques des voies urinaires › Capacité de concentration rénale › Urinary concentrating defect in mice lacking...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Urinary concentrating defect in mice lacking...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Souris transgéniques › Souris knockout › Urinary concentrating defect in mice lacking...
questionsmedicales.fr › Phénomènes chimiques › Perméabilité › Osmose › Urinary concentrating defect in mice lacking...
questionsmedicales.fr › États, signes et symptômes pathologiques › Signes et symptômes › Manifestations urologiques › Polyurie › Urinary concentrating defect in mice lacking...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Protéines de transport membranaire › Protéines transporteurs de solutés › Antiport des ions sodium-hydrogène › Échangeur-3 de sodium-hydrogène › Urinary concentrating defect in mice lacking...