Akkermansia muciniphila strain ATCC BAA-835 does not promote short-term intestinal inflammation in gnotobiotic interleukin-10-deficient mice.
Animals
Body Weight
Cecum
/ microbiology
Disease Models, Animal
Escherichia coli
/ physiology
Gastrointestinal Microbiome
Germ-Free Life
Humans
Inflammation
/ metabolism
Inflammation Mediators
/ analysis
Inflammatory Bowel Diseases
/ microbiology
Interleukin-10
/ deficiency
Intestines
/ microbiology
Male
Mice
Mice, Knockout
Mucus
/ metabolism
Verrucomicrobia
/ growth & development
None
NC101
IL-10-deficient
gnotobiotic mice
intestinal inflammation
simplified human intestinal microbiota
Journal
Gut microbes
ISSN: 1949-0984
Titre abrégé: Gut Microbes
Pays: United States
ID NLM: 101495343
Informations de publication
Date de publication:
2019
2019
Historique:
pubmed:
27
9
2018
medline:
8
8
2019
entrez:
26
9
2018
Statut:
ppublish
Résumé
Akkermansia muciniphila is a common member of the intestinal microbiota of healthy human individuals. Its abundance is negatively associated with inflammatory bowel disease and metabolic disorders and the oral administration of A. muciniphila improves the symptoms of metabolic disease in mice. Therefore, A. muciniphila is a promising candidate for the treatment of type-2 diabetes and obesity. However, some studies using animal models of intestinal inflammation reported that A. muciniphila may exacerbate gut inflammation. Because of these contradictory reports the present study aimed to clarify the role of A. muciniphila in the development of intestinal inflammation and the conditions promoting it. For this purpose, the short-term colitogenic potential of A. muciniphila strain ATCC BAA-835 was investigated in colitis-prone, gnotobiotic IL-10-deficient (Il10
Identifiants
pubmed: 30252588
doi: 10.1080/19490976.2018.1511663
pmc: PMC6546315
doi:
Substances chimiques
IL10 protein, mouse
0
Inflammation Mediators
0
Interleukin-10
130068-27-8
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Pagination
188-203Références
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