Micro-CT imaging and structural analysis of glomeruli in a model of Adriamycin-induced nephropathy.
Algorithms
Animals
Barium Sulfate
/ administration & dosage
Contrast Media
/ administration & dosage
Disease Models, Animal
Doxorubicin
Glomerulosclerosis, Focal Segmental
/ chemically induced
Image Interpretation, Computer-Assisted
Kidney Glomerulus
/ diagnostic imaging
Male
Mice, Inbred C57BL
Predictive Value of Tests
X-Ray Microtomography
Adriamycin nephropathy
glomerular spatial density
glomeruli structural analysis
image analysis algorithms
juxtamedullary kidney layers
left-right asymmetry
micro-CT
midcortical
superficial
volume heterogeneity
Journal
American journal of physiology. Renal physiology
ISSN: 1522-1466
Titre abrégé: Am J Physiol Renal Physiol
Pays: United States
ID NLM: 100901990
Informations de publication
Date de publication:
01 01 2019
01 01 2019
Historique:
pubmed:
27
9
2018
medline:
26
11
2019
entrez:
27
9
2018
Statut:
ppublish
Résumé
Glomeruli number and size are important for determining the pathogenesis of glomerular disease, chronic kidney disease, and hypertension. Moreover, renal injury can occur in specific cortical layers and alter glomerular spatial distribution. In this study, we present a comprehensive structural analysis of glomeruli in a model of Adriamycin (doxorubicin) nephropathy. Glomeruli are imaged (micro-CT at 10 × 10 × 10 μm
Identifiants
pubmed: 30256127
doi: 10.1152/ajprenal.00331.2018
doi:
Substances chimiques
Contrast Media
0
Barium Sulfate
25BB7EKE2E
Doxorubicin
80168379AG
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM