Cryptococcal Meningitis Diagnostics and Screening in the Era of Point-of-Care Laboratory Testing.
Cryptococcus
diagnostics
point-of-care
prevention
Journal
Journal of clinical microbiology
ISSN: 1098-660X
Titre abrégé: J Clin Microbiol
Pays: United States
ID NLM: 7505564
Informations de publication
Date de publication:
01 2019
01 2019
Historique:
received:
31
07
2018
accepted:
07
09
2018
pubmed:
28
9
2018
medline:
31
1
2020
entrez:
28
9
2018
Statut:
epublish
Résumé
Over the past ten years, standard diagnostics for cryptococcal meningitis in HIV-infected persons have evolved from culture to India ink to detection of cryptococcal antigen (CrAg), with the recent development and distribution of a point-of-care lateral flow assay. This assay is highly sensitive and specific in cerebrospinal fluid (CSF), but is also sensitive in the blood to detect CrAg prior to meningitis symptoms. CrAg screening of HIV-infected persons in the blood prior to development of fulminant meningitis and preemptive treatment for CrAg-positive persons are recommended by the World Health Organization and many national HIV guidelines. Thus, CrAg testing is occurring more widely, especially in resource-limited laboratory settings. CrAg titer predicts meningitis and death and could be used in the future to customize therapy according to burden of infection.
Identifiants
pubmed: 30257903
pii: JCM.01238-18
doi: 10.1128/JCM.01238-18
pmc: PMC6322457
pii:
doi:
Substances chimiques
Antigens, Fungal
0
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : NIAID NIH HHS
ID : K23 AI138851
Pays : United States
Organisme : NIAID NIH HHS
ID : R01 AI118511
Pays : United States
Organisme : NIAID NIH HHS
ID : U01 AI125003
Pays : United States
Informations de copyright
Copyright © 2019 American Society for Microbiology.
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