Activation of lateral hypothalamic area neurotensin-expressing neurons promotes drinking.
DREADDs
Feeding
Fluid homeostasis
Ingestive behavior
Osmolality
Water intake
Journal
Neuropharmacology
ISSN: 1873-7064
Titre abrégé: Neuropharmacology
Pays: England
ID NLM: 0236217
Informations de publication
Date de publication:
08 2019
08 2019
Historique:
received:
01
07
2018
revised:
04
09
2018
accepted:
24
09
2018
pubmed:
30
9
2018
medline:
29
2
2020
entrez:
30
9
2018
Statut:
ppublish
Résumé
Animals must ingest water via drinking to maintain fluid homeostasis, yet the neurons that specifically promote drinking behavior are incompletely characterized. The lateral hypothalamic area (LHA) as a whole is essential for drinking behavior but most LHA neurons indiscriminately promote drinking and feeding. By contrast, activating neurotensin (Nts)-expressing LHA neurons (termed LHA Nts neurons) causes mice to immediately drink water with a delayed suppression of feeding. We therefore hypothesized that LHA Nts neurons are sufficient to induce drinking behavior and that these neurons specifically bias for fluid intake over food intake. To test this hypothesis we used designer receptors exclusively activated by designer drugs (DREADDs) to selectively activate LHA Nts neurons and studied the impact on fluid intake, fluid preference and feeding. Activation of LHA Nts neurons stimulated drinking in water-replete and dehydrated mice, indicating that these neurons are sufficient to promote water intake regardless of homeostatic need. Interestingly, mice with activated LHA Nts neurons drank any fluid that was provided regardless of its palatability, but if given a choice they preferred water or palatable solutions over unpalatable (quinine) or dehydrating (hypertonic saline) solutions. Notably, acute activation of LHA Nts neurons robustly promoted fluid but not food intake. Overall, our study confirms that activation of LHA Nts neurons is sufficient to induce drinking behavior and biases for fluid intake. Hence, LHA Nts neurons may be important targets for orchestrating the appropriate ingestive behavior necessary to maintain fluid homeostasis. This article is part of the Special Issue entitled 'Hypothalamic Control of Homeostasis'.
Identifiants
pubmed: 30266601
pii: S0028-3908(18)30707-X
doi: 10.1016/j.neuropharm.2018.09.038
pmc: PMC6433557
mid: NIHMS1508625
pii:
doi:
Substances chimiques
Neurotensin
39379-15-2
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Langues
eng
Sous-ensembles de citation
IM
Pagination
13-21Subventions
Organisme : NIDDK NIH HHS
ID : P30 DK020572
Pays : United States
Organisme : NIDDK NIH HHS
ID : R01 DK103808
Pays : United States
Informations de copyright
Copyright © 2018 Elsevier Ltd. All rights reserved.
Références
Int J Mol Med. 2005 Jun;15(6):1033-9
pubmed: 15870910
Behav Brain Res. 2003 Mar 18;140(1-2):49-55
pubmed: 12644277
PLoS One. 2013 Apr 19;8(4):e62391
pubmed: 23620827
J Neurosci. 2011 Oct 26;31(43):15455-67
pubmed: 22031892
J Neurosci. 2016 Aug 3;36(31):8228-37
pubmed: 27488641
Mol Metab. 2015 Jul 16;4(10):706-17
pubmed: 26500842
Am J Physiol Regul Integr Comp Physiol. 2003 Feb;284(2):R494-9
pubmed: 12557891
Brain Res. 2000 Oct 27;881(2):176-81
pubmed: 11036156
Rev Endocr Metab Disord. 2017 Mar;18(1):49-66
pubmed: 28303369
J Physiol. 1978 Mar;276:435-48
pubmed: 650470
Int J Eat Disord. 2007 May;40(4):360-8
pubmed: 17347988
Exp Neurol. 1967 Feb;17(2):119-27
pubmed: 6018354
Nature. 2016 Sep 29;537(7622):680-684
pubmed: 27487211
Proc Natl Acad Sci U S A. 1986 Mar;83(5):1528-31
pubmed: 3513180
Nat Neurosci. 2016 Feb;19(2):198-205
pubmed: 26814589
J Comp Neurol. 1979 Feb 15;183(4):689-706
pubmed: 105019
J Neurosci. 2015 Feb 25;35(8):3312-8
pubmed: 25716832
Nature. 2015 Apr 16;520(7547):349-52
pubmed: 25624099
J Neuroendocrinol. 2016 Mar;28(3):12357
pubmed: 26716764
J Neurosci. 1995 Apr;15(4):2609-27
pubmed: 7536817
J Neurosci. 2014 Aug 20;34(34):11405-15
pubmed: 25143620
Cell Metab. 2011 Sep 7;14(3):313-23
pubmed: 21907138
Neuropharmacology. 2014 Oct;85:451-60
pubmed: 24951857
Br J Nutr. 2015 Jan 14;113(1):147-58
pubmed: 25418739
J Comp Neurol. 2012 Jun 15;520(9):1831-90
pubmed: 22488503
J Comp Physiol Psychol. 1976 Feb;90(2):127-43
pubmed: 1249268
Brain Res. 2008 Oct 9;1234:66-77
pubmed: 18722360
J Comp Neurol. 2005 Dec 19;493(3):412-38
pubmed: 16261534
Nat Rev Neurosci. 2008 Jul;9(7):519-31
pubmed: 18509340
N Engl J Med. 1984 Sep 20;311(12):753-9
pubmed: 6472364
Neuron. 2017 Dec 20;96(6):1272-1281.e4
pubmed: 29268095
Endocrinology. 2017 May 1;158(5):1271-1288
pubmed: 28323938
J Neurosci. 2002 Feb 1;22(3):977-90
pubmed: 11826126
Eur J Pharmacol. 1982 Jul 16;81(3):499-503
pubmed: 6811292
Cell Metab. 2009 Aug;10(2):89-98
pubmed: 19656487
Curr Hypertens Rep. 2017 Jun;19(6):50
pubmed: 28528375
Peptides. 1980 Winter;1(4):333-9
pubmed: 7301636
Curr Psychiatry Rep. 2007 Jun;9(3):236-41
pubmed: 17521521
Nat Rev Neurosci. 2017 Aug;18(8):459-469
pubmed: 28638120
Nature. 2015 May 14;521(7551):180-185
pubmed: 25915020
Schizophr Res. 2009 Feb;107(2-3):128-33
pubmed: 18984069
Am J Physiol Endocrinol Metab. 2013 May 1;304(9):E999-1011
pubmed: 23482448
J Neurophysiol. 2016 Jun 1;115(6):3123-9
pubmed: 27030736
J Physiol. 1970 Sep;210(2):457-74
pubmed: 4322723
Obesity (Silver Spring). 2009 Jun;17(6):1135-43
pubmed: 19214175
Nature. 2018 Mar 8;555(7695):204-209
pubmed: 29489747
Proc Natl Acad Sci U S A. 1998 Jan 6;95(1):322-7
pubmed: 9419374
J Neurosci. 2018 Aug 1;38(31):6841-6853
pubmed: 29934352
Nutr Rev. 2012 Nov;70 Suppl 2:S152-5
pubmed: 23121352
Behav Brain Res. 2001 Jan 29;118(2):111-6
pubmed: 11164508
Brain Res Rev. 2010 Sep;64(1):14-103
pubmed: 20170674
Nature. 1976 Aug 12;262(5569):607-9
pubmed: 8728
Neuropharmacology. 2010 Jan;58(1):195-8
pubmed: 19596358
J Neurosci. 2017 Jun 21;37(25):6053-6065
pubmed: 28539422
Cell. 2015 Jan 29;160(3):516-27
pubmed: 25635459
PLoS One. 2015 Apr 21;10(4):e0124523
pubmed: 25897513
J Physiol. 2013 Feb 15;591(4):933-53
pubmed: 23184514
Am J Physiol Cell Physiol. 2003 Jul;285(1):C96-101
pubmed: 12777254
Brain Res. 1989 May 15;487(1):188-91
pubmed: 2752285
Brain Res. 2001 Jan 12;888(2):343-347
pubmed: 11150496
Brain Res. 1992 May 29;581(2):208-16
pubmed: 1393529
Brain Res Bull. 1999 Mar 15;48(5):521-5
pubmed: 10372513
Cell. 1998 Feb 20;92(4):573-85
pubmed: 9491897
Brain Res. 1999 Dec 4;849(1-2):248-52
pubmed: 10592311
Pflugers Arch. 1990 Nov;417(3):336-41
pubmed: 2274418
Behav Genet. 2002 Nov;32(6):445-57
pubmed: 12467342
Brain Res. 2000 May 19;865(1):35-44
pubmed: 10814731
Mol Metab. 2013 Aug 07;2(4):423-34
pubmed: 24327958
Neuropsychopharmacology. 2016 May;41(6):1505-12
pubmed: 26442599
Physiol Behav. 1999 Jan 1-15;65(4-5):871-8
pubmed: 10073494
Elife. 2013 Dec 31;2:e01462
pubmed: 24381247
Am J Physiol Regul Integr Comp Physiol. 2006 Sep;291(3):R533-40
pubmed: 16556901
Cell. 2015 Jan 29;160(3):528-41
pubmed: 25635460
Biochim Biophys Acta Mol Basis Dis. 2018 Mar;1864(3):900-916
pubmed: 29288794
Cell Rep. 2017 Dec 12;21(11):3116-3128
pubmed: 29241540
Neuroscience. 1994 May;60(1):255-62
pubmed: 8052417
J Comp Neurol. 1992 May 8;319(2):218-45
pubmed: 1522246
Endocrinology. 2015 May;156(5):1692-700
pubmed: 25734363
Am J Physiol. 1958 Apr;193(1):230-4
pubmed: 13521013
Am J Physiol Regul Integr Comp Physiol. 2013 Oct 1;305(7):R669-78
pubmed: 23883678
Physiol Behav. 2004 Jul;81(5):795-803
pubmed: 15234185
Nat Neurosci. 2017 Feb;20(2):230-241
pubmed: 27991901
J Comp Neurol. 2007 Jun 10;502(5):768-82
pubmed: 17436292
eNeuro. 2017 Sep 22;4(5):
pubmed: 28966976