Mitophagy-driven metabolic switch reprograms stem cell fate.
Cellular reprogramming
Differentiation
Metabolic shift
Mitophagy
Stemness
Journal
Cellular and molecular life sciences : CMLS
ISSN: 1420-9071
Titre abrégé: Cell Mol Life Sci
Pays: Switzerland
ID NLM: 9705402
Informations de publication
Date de publication:
Jan 2019
Jan 2019
Historique:
received:
27
07
2018
accepted:
19
09
2018
revised:
12
09
2018
pubmed:
30
9
2018
medline:
23
1
2019
entrez:
30
9
2018
Statut:
ppublish
Résumé
"Cellular reprogramming" facilitates the generation of desired cellular phenotype through the cell fate transition by affecting the mitochondrial dynamics and metabolic reshuffle in the embryonic and somatic stem cells. Interestingly, both the processes of differentiation and dedifferentiation witness a drastic and dynamic alteration in the morphology, number, distribution, and respiratory capacity of mitochondria, which are tightly regulated by the fission/fusion cycle, and mitochondrial clearance through autophagy following mitochondrial fission. Intriguingly, mitophagy is said to be essential in the differentiation of stem cells into various lineages such as erythrocytes, eye lenses, neurites, myotubes, and M1 macrophages. Mitophagy is also believed to play a central role in the dedifferentiation of a terminally differentiated cell into an induced pluripotent cell and in the acquisition of 'stemness' in cancer cells. Mitophagy-induced alteration in the mitochondrial dynamics facilitates metabolic shift, either into a glycolytic phenotype or into an OXPHOS phenotype, depending on the cellular demand. Mitophagy-induced rejuvenation of mitochondria regulates the transition of bioenergetics and metabolome, remodeling which facilitates an alteration in their cellular developmental capability. This review describes the detailed mechanism of the process of mitophagy and its association with cellular programming through alteration in the mitochondrial energetics. The metabolic shift post mitophagy is suggested to be a key factor in the cell fate transition during differentiation and dedifferentiation.
Identifiants
pubmed: 30267101
doi: 10.1007/s00018-018-2922-9
pii: 10.1007/s00018-018-2922-9
doi:
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
27-43Subventions
Organisme : DBT India Alliance
ID : BT/PR7791/BRB/10/1187/2013
Organisme : Board of Research in Nuclear Sciences
ID : 37(1)/14/38/2016-BRNS/37276
Organisme : Science and Engineering Research Board
ID : EMR/2016/001246
Références
Nature. 2001 Nov 1;414(6859):105-11
pubmed: 11689955
FEBS Lett. 2003 Mar 13;538(1-3):53-9
pubmed: 12633852
Nature. 1958 Jul 5;182(4627):64-5
pubmed: 13566187
Neurobiol Aging. 2006 Apr;27(4):524-9
pubmed: 16213628
Proc Natl Acad Sci U S A. 1952 May;38(5):455-63
pubmed: 16589125
Cell Death Differ. 2007 Jan;14(1):146-57
pubmed: 16645637
Nature. 2006 Jun 29;441(7097):1157-61
pubmed: 16672980
Cell. 2006 Aug 25;126(4):663-76
pubmed: 16904174
EMBO J. 2007 Apr 4;26(7):1913-23
pubmed: 17347648
Cloning Stem Cells. 2007 Spring;9(1):3-7
pubmed: 17386005
Arch Biochem Biophys. 2007 Jun 15;462(2):245-53
pubmed: 17475204
J Biol Chem. 2007 Aug 17;282(33):24131-45
pubmed: 17580304
Nat Rev Mol Cell Biol. 2007 Oct;8(10):774-85
pubmed: 17712357
J Cell Sci. 2007 Nov 15;120(Pt 22):4025-34
pubmed: 17971411
Science. 2007 Dec 21;318(5858):1917-20
pubmed: 18029452
Cell. 2007 Nov 30;131(5):861-72
pubmed: 18035408
EMBO J. 2008 Jan 23;27(2):433-46
pubmed: 18200046
Cell Stem Cell. 2008 Jan 10;2(1):10-2
pubmed: 18371415
Cell Stem Cell. 2008 Feb 7;2(2):151-9
pubmed: 18371436
Nature. 2008 Jul 10;454(7201):232-5
pubmed: 18454133
J Biol Chem. 2008 Aug 15;283(33):22847-57
pubmed: 18524774
Genes Cells. 2008 Dec;13(12):1211-8
pubmed: 19021777
J Cell Biol. 2008 Dec 1;183(5):795-803
pubmed: 19029340
Cell Death Differ. 2009 Jul;16(7):939-46
pubmed: 19229244
Cell Stem Cell. 2009 Jun 5;4(6):487-92
pubmed: 19497275
Cell Cycle. 2009 Jul 1;8(13):1986-90
pubmed: 19502794
Nat Genet. 2009 Oct;41(10):1138-43
pubmed: 19718028
Hum Mol Genet. 2009 Oct 15;18(R2):R169-76
pubmed: 19808793
Proc Natl Acad Sci U S A. 2009 Dec 1;106(48):20405-10
pubmed: 19918075
EMBO Rep. 2010 Jan;11(1):45-51
pubmed: 20010802
Cell Death Differ. 2010 Jun;17(6):962-74
pubmed: 20057503
Stem Cells. 2010 Apr;28(4):661-73
pubmed: 20073085
FEBS Lett. 2010 Apr 2;584(7):1379-85
pubmed: 20083108
Nat Cell Biol. 2010 Feb;12(2):119-31
pubmed: 20098416
PLoS Biol. 2010 Jan 26;8(1):e1000298
pubmed: 20126261
Mol Biol Cell. 2010 Apr 1;21(7):1225-36
pubmed: 20147447
Stem Cells. 2010 Apr;28(4):721-33
pubmed: 20201066
J Cell Biol. 2010 Apr 19;189(2):211-21
pubmed: 20404107
J Biol Chem. 2010 Aug 13;285(33):25308-13
pubmed: 20538613
Autophagy. 2010 Aug;6(6):821-2
pubmed: 20581476
Autophagy. 2010 Nov;6(8):1090-106
pubmed: 20890124
Biochim Biophys Acta. 2011 Jun;1807(6):543-51
pubmed: 21035425
J Cell Biol. 2010 Nov 29;191(5):933-42
pubmed: 21115803
Antioxid Redox Signal. 2011 May 15;14(10):1971-8
pubmed: 21126221
Science. 2011 Jan 28;331(6016):456-61
pubmed: 21205641
PLoS One. 2011 Jan 17;6(1):e16054
pubmed: 21264221
PLoS One. 2011 Jan 17;6(1):e16060
pubmed: 21264228
Hum Mol Genet. 2011 May 1;20(9):1726-37
pubmed: 21296869
J Exp Med. 2011 Mar 14;208(3):455-67
pubmed: 21339326
EMBO J. 2011 Apr 6;30(7):1195-208
pubmed: 21358617
J Neurochem. 2011 Jun;117(5):856-67
pubmed: 21426348
PLoS One. 2011;6(6):e20914
pubmed: 21698063
Stem Cells. 2011 Sep;29(9):1338-48
pubmed: 21732474
J Neurosci. 2011 Jul 13;31(28):10249-61
pubmed: 21753002
Cell Metab. 2011 Aug 3;14(2):264-71
pubmed: 21803296
Nature. 2011 Dec 1;480(7375):113-7
pubmed: 22020285
Cell Res. 2012 Jan;22(1):168-77
pubmed: 22064701
Antioxid Redox Signal. 2012 Sep 1;17(5):794-802
pubmed: 22077334
EMBO J. 2011 Nov 15;30(24):4860-73
pubmed: 22085932
Nat Cell Biol. 2012 Jan 22;14(2):177-85
pubmed: 22267086
EMBO J. 2012 May 2;31(9):2103-16
pubmed: 22446391
J Biol Chem. 2012 Jun 1;287(23):19094-104
pubmed: 22505714
Aging (Albany NY). 2012 Jun;4(6):393-401
pubmed: 22713507
Biochim Biophys Acta. 2012 Dec;1823(12):2297-310
pubmed: 22917578
Nat Chem Biol. 2012 Oct;8(10):831-8
pubmed: 22922758
Science. 2012 Aug 31;337(6098):1062-5
pubmed: 22936770
J Biol Chem. 2013 Jan 11;288(2):1099-113
pubmed: 23209295
Cell Cycle. 2013 Jan 15;12(2):207-18
pubmed: 23287468
Science. 2013 Apr 19;340(6130):350-3
pubmed: 23493425
Nature. 2013 Apr 18;496(7445):372-6
pubmed: 23503661
Cell Metab. 2013 May 7;17(5):719-30
pubmed: 23602449
Science. 2013 Apr 26;340(6131):471-5
pubmed: 23620051
EMBO Rep. 2013 Jul;14(7):638-44
pubmed: 23722655
Cell Metab. 2013 Sep 3;18(3):325-32
pubmed: 23850316
Am J Physiol Regul Integr Comp Physiol. 2013 Oct 15;305(8):R927-38
pubmed: 23904108
J Cell Sci. 2013 Aug 1;126(Pt 15):3237-47
pubmed: 23908376
Stem Cells. 2013 Nov;31(11):2374-87
pubmed: 23939908
Exp Eye Res. 2013 Nov;116:141-50
pubmed: 24012988
Autophagy. 2013 Nov 1;9(11):1900-1
pubmed: 24025250
Nat Cell Biol. 2013 Oct;15(10):1197-1205
pubmed: 24036476
J Proteomics. 2014 Jan 16;96:253-62
pubmed: 24275569
Gerontology. 2014;60(2):174-82
pubmed: 24281332
Antioxid Redox Signal. 2014 Sep 1;21(7):1009-24
pubmed: 24329038
EMBO J. 2014 Feb 18;33(4):282-95
pubmed: 24446486
EMBO Rep. 2014 May;15(5):566-75
pubmed: 24671035
Mol Cell. 2014 May 8;54(3):362-77
pubmed: 24746696
J Cell Biol. 2014 Apr 28;205(2):143-53
pubmed: 24751536
Nature. 2014 Jun 5;510(7503):162-6
pubmed: 24784582
G3 (Bethesda). 2014 Jun 13;4(8):1515-27
pubmed: 24928582
Mol Cell. 2014 Aug 7;55(3):451-66
pubmed: 24999239
Cell Death Differ. 2014 Dec;21(12):1862-76
pubmed: 25080938
Cell Stem Cell. 2014 Oct 2;15(4):471-487
pubmed: 25090446
Autophagy. 2014 Oct 1;10(10):1712-25
pubmed: 25126723
Nat Rev Endocrinol. 2014 Nov;10(11):650-8
pubmed: 25200564
Cell. 2014 Sep 11;158(6):1254-1269
pubmed: 25215486
Cell Death Differ. 2015 Mar;22(3):419-32
pubmed: 25215947
Oncotarget. 2014 Sep 30;5(18):8306-16
pubmed: 25246709
Mol Cell. 2014 Nov 6;56(3):360-75
pubmed: 25284222
Proc Natl Acad Sci U S A. 2014 Oct 21;111(42):E4439-48
pubmed: 25294927
EMBO J. 2015 Jan 13;34(2):138-53
pubmed: 25476451
Cell Cycle. 2015;14(1):86-98
pubmed: 25483072
Cell Mol Life Sci. 2015 May;72(9):1759-77
pubmed: 25586562
Cell Stem Cell. 2015 Feb 5;16(2):171-83
pubmed: 25600643
Cell Metab. 2015 Feb 3;21(2):273-286
pubmed: 25600785
Cell Death Differ. 2015 Dec;22(12):1957-69
pubmed: 25882047
Stem Cells Dev. 2015 Sep 1;24(17):1957-71
pubmed: 26134242
J Biol Chem. 2015 Sep 4;290(36):22005-18
pubmed: 26134559
Nat Commun. 2015 Jul 06;6:7527
pubmed: 26146385
Nature. 2015 Aug 20;524(7565):309-314
pubmed: 26266977
Nat Commun. 2015 Aug 14;6:7926
pubmed: 26272043
Nat Commun. 2015 Oct 07;6:8472
pubmed: 26442449
Autophagy. 2015;11(10):1932-3
pubmed: 26506896
Autophagy. 2016;12(2):369-80
pubmed: 26566717
Cell Mol Life Sci. 2016 Feb;73(4):775-95
pubmed: 26611876
Science. 2015 Dec 4;350(6265):aad2459
pubmed: 26785495
Immunity. 2016 Mar 15;44(3):582-596
pubmed: 26921108
J Mol Cell Cardiol. 2016 Jun;95:50-6
pubmed: 27021519
Aging (Albany NY). 2016 Jul;8(7):1330-52
pubmed: 27295498
Sci Rep. 2016 Aug 18;6:31462
pubmed: 27535796
Cell Metab. 2016 Sep 13;24(3):402-419
pubmed: 27568548
Autophagy. 2016 Nov;12(11):2000-2008
pubmed: 27575019
Science. 2016 Dec 2;354(6316):1156-1160
pubmed: 27738012
Cell Cycle. 2016 Dec;15(23):3240-3250
pubmed: 27753531
Int J Hematol. 2017 Feb;105(2):162-173
pubmed: 27796739
Oral Oncol. 2016 Nov;62:122-135
pubmed: 27865365
Cancer Lett. 2017 Mar 1;388:34-42
pubmed: 27913197
Cell. 2017 Jan 12;168(1-2):224-238.e10
pubmed: 28017329
Dev Cell. 2017 Mar 27;40(6):583-594.e6
pubmed: 28350990
EMBO J. 2017 May 15;36(10):1330-1347
pubmed: 28377463
Oncogene. 2017 Aug 24;36(34):4843-4858
pubmed: 28414310
Theranostics. 2017 Mar 23;7(5):1389-1406
pubmed: 28435473
EMBO J. 2017 Jun 14;36(12):1688-1706
pubmed: 28465321
Cell Death Differ. 2017 Jul;24(7):1224-1238
pubmed: 28524859
Autophagy. 2018;14(5):915-917
pubmed: 28614042
J Cell Biol. 2017 Aug 7;216(8):2315-2327
pubmed: 28663346
Autophagy. 2017 Sep 2;13(9):1543-1555
pubmed: 28722510
Oxid Med Cell Longev. 2017;2017:3861790
pubmed: 28831295
Mol Cell. 2017 Oct 19;68(2):281-292.e5
pubmed: 29033320
Redox Biol. 2018 Apr;14:474-484
pubmed: 29096320
Cell Prolif. 2018 Feb;51(1):null
pubmed: 29171106
Biochim Biophys Acta Mol Cell Res. 2018 Mar;1865(3):480-495
pubmed: 29229477
Annu Rev Physiol. 1966;28:435-92
pubmed: 5322983