Tranexamic Acid Ameliorates Nonmelanoma Skin Cancer Induced by Long-term Ultraviolet A Irradiation.

Animals Dose-Response Relationship, Drug Male Mice, Hairless Neoplasms, Radiation-Induced / drug therapy Skin Neoplasms / pathology Tranexamic Acid / administration & dosage Ultraviolet Rays

Journal

Photochemistry and photobiology
ISSN: 1751-1097
Titre abrégé: Photochem Photobiol
Pays: United States
ID NLM: 0376425

Informations de publication

Date de publication:
03 2019
Historique:
received: 10 07 2018
accepted: 06 09 2018
pubmed: 30 9 2018
medline: 19 7 2019
entrez: 30 9 2018
Statut: ppublish

Résumé

To date, there have been no treatments developed to ameliorate nonmelanoma skin cancer induced by long-term exposure to ultraviolet A (UVA) irradiation. In this study, we examined the effects of tranexamic acid (trans-4-aminomethyl cyclohexanecarboxylic acid) on long-term UVA-induced skin cancer. We exposed the dorsal skin of male hairless mice to UVA at a dose of 110 kJ m

Identifiants

DOI: 10.1111/php.13025 PMID: 30267577
pubmed: 30267577
doi: 10.1111/php.13025
doi:

Substances chimiques

Tranexamic Acid 6T84R30KC1

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

612-617

Subventions

Organisme : JSPS KAKENHI
ID : 18K11085
Pays : International

Informations de copyright

© 2018 The American Society of Photobiology.

Auteurs

Keiichi Hiramoto (K)

Department of Pharmaceutical Sciences, Suzuka University of Medical Science, Suzuka, Mie, Japan.

Yurika Yamate (Y)

Department of Pharmaceutical Sciences, Suzuka University of Medical Science, Suzuka, Mie, Japan.

Daijiro Sugiyama (D)

Department of Pharmaceutical Sciences, Suzuka University of Medical Science, Suzuka, Mie, Japan.

Kazunari Matsuda (K)

R&D Department, Daiichi Sankyo Healthcare Co., LTD., Chuo-ku, Tokyo, Japan.

Yasutaka Iizuka (Y)

R&D Department, Daiichi Sankyo Healthcare Co., LTD., Chuo-ku, Tokyo, Japan.

Tomohiko Yamaguchi (T)

R&D Department, Daiichi Sankyo Healthcare Co., LTD., Chuo-ku, Tokyo, Japan.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Tranexamic Acid Ameliorates Nonmelanoma Skin...
questionsmedicales.fr › Phénomènes physiologiques › Phénomènes pharmacologiques et toxicologiques › Phénomènes toxicologiques › Relation dose-effet des médicaments › Tranexamic Acid Ameliorates Nonmelanoma Skin...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Souches mutantes de souris › Souris hairless › Tranexamic Acid Ameliorates Nonmelanoma Skin...
questionsmedicales.fr › Phénomènes physiques › Rayonnement › Tumeurs radio-induites › Tranexamic Acid Ameliorates Nonmelanoma Skin...
questionsmedicales.fr › Maladies de la peau et du tissu conjonctif › Maladies de la peau › Tumeurs cutanées › Tranexamic Acid Ameliorates Nonmelanoma Skin...
questionsmedicales.fr › Composés chimiques organiques › Acides carboxyliques › Acides carbocycliques › Acide tranéxamique › Tranexamic Acid Ameliorates Nonmelanoma Skin...
questionsmedicales.fr › Environnement et santé publique › Environnement › Concepts météorologiques › Atmosphère › Temps (météorologie) › Lumière du soleil › Rayons ultraviolets › Tranexamic Acid Ameliorates Nonmelanoma Skin...