Triacetylfusarinine C: A urine biomarker for diagnosis of invasive aspergillosis.
Aspergillosis
Biomarker
Diagnosis
Siderophore
Urine
Journal
The Journal of infection
ISSN: 1532-2742
Titre abrégé: J Infect
Pays: England
ID NLM: 7908424
Informations de publication
Date de publication:
02 2019
02 2019
Historique:
received:
01
06
2018
revised:
20
08
2018
accepted:
11
09
2018
pubmed:
30
9
2018
medline:
29
5
2020
entrez:
30
9
2018
Statut:
ppublish
Résumé
Early diagnosis of invasive aspergillosis (IA) remains challenging, with available diagnostics being limited by inadequate sensitivities and specificities. Triacetylfusarinine C, a fungal siderophore that has been shown to accumulate in urine in animal models, is a potential new biomarker for diagnosis of IA. We developed a method allowing absolute and matrix-independent mass spectrometric quantification of TAFC. Urine TAFC, normalized to creatinine, was determined in 44 samples from 24 patients with underlying hematologic malignancies and probable, possible or no IA according to current EORTC/MSG criteria and compared to other established biomarkers measured in urine and same-day blood samples. TAFC/creatinine sensitivity, specificity, positive and negative likelihood ratio for probable versus no IA (cut-off ≥ 3) were 0.86, 0.88, 6.86, 0.16 per patient. For the first time, we provide proof for the occurrence of TAFC in human urine. TAFC/creatinine index determination in urine showed promising results for diagnosis of IA offering the advantages of non-invasive sampling. Sensitivity and specificity were similar as reported for GM determination in serum and bronchoalveolar lavage, the gold standard mycological criterion for IA diagnosis.
Identifiants
pubmed: 30267801
pii: S0163-4453(18)30279-2
doi: 10.1016/j.jinf.2018.09.006
pmc: PMC6361682
mid: NIHMS1509015
pii:
doi:
Substances chimiques
Biomarkers
0
Ferric Compounds
0
Hydroxamic Acids
0
Siderophores
0
N,N',N''-triacetylfusarinine C
59200-35-0
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
150-157Subventions
Organisme : NIAID NIH HHS
ID : P30 AI036214
Pays : United States
Organisme : NIMH NIH HHS
ID : R21 MH113477
Pays : United States
Organisme : Austrian Science Fund FWF
ID : W 1253
Pays : Austria
Informations de copyright
Copyright © 2018 The Authors. Published by Elsevier Ltd.. All rights reserved.
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