The sympathetic nervous system regulates skeletal muscle motor innervation and acetylcholine receptor stability.

Acetylcholine / metabolism Animals Mice Motor Neurons / metabolism Muscle, Skeletal / metabolism Muscular Atrophy / metabolism Neuromuscular Junction / physiology Receptors, Cholinergic / metabolism Sympathetic Nervous System / metabolism Synaptic Transmission / physiology
muscle denervation muscle innervation neuromuscular junction skeletal muscle sympathetic nervous system

Journal

Acta physiologica (Oxford, England)
ISSN: 1748-1716
Titre abrégé: Acta Physiol (Oxf)
Pays: England
ID NLM: 101262545

Informations de publication

Date de publication:
03 2019
Historique:
received: 27 03 2018
revised: 23 09 2018
accepted: 26 09 2018
pubmed: 1 10 2018
medline: 4 6 2020
entrez: 1 10 2018
Statut: ppublish

Résumé

Symptoms of autonomic failure are frequently the presentation of advanced age and neurodegenerative diseases that impair adaptation to common physiologic stressors. The aim of this work was to examine the interaction between the sympathetic and motor nervous system, the involvement of the sympathetic nervous system (SNS) in neuromuscular junction (NMJ) presynaptic motor function, the stability of postsynaptic molecular organization, and the skeletal muscle composition and function. Since muscle weakness is a symptom of diseases characterized by autonomic dysfunction, we studied the impact of regional sympathetic ablation on muscle motor innervation by using transcriptome analysis, retrograde tracing of the sympathetic outflow to the skeletal muscle, confocal and electron microscopy, NMJ transmission by electrophysiological methods, protein analysis, and state of the art microsurgical techniques, in C57BL6, MuRF1KO and Thy-1 mice. We found that the SNS regulates motor nerve synaptic vesicle release, skeletal muscle transcriptome, muscle force generated by motor nerve activity, axonal neurofilament phosphorylation, myelin thickness, and myofibre subtype composition and CSA. The SNS also modulates the levels of postsynaptic membrane acetylcholine receptor by regulating the Gα The SNS regulates NMJ transmission, maintains optimal Gα

Identifiants

DOI: 10.1111/apha.13195 PMID: 30269419 PMC: PMC7224611
pubmed: 30269419
doi: 10.1111/apha.13195
pmc: PMC7224611
mid: NIHMS1583867
doi:

Substances chimiques

Receptors, Cholinergic 0
Acetylcholine N9YNS0M02X

Types de publication

Journal Article Research Support, N.I.H., Extramural

Langues

eng

Sous-ensembles de citation

IM

Pagination

e13195

Subventions

Organisme : NIA NIH HHS
ID : R29 AG013934
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL104129
Pays : United States
Organisme : NIA NIH HHS
ID : R01 AG013934
Pays : United States
Organisme : NIA NIH HHS
ID : P30 AG021332
Pays : United States
Organisme : NIA NIH HHS
ID : R01 AG057013
Pays : United States

Informations de copyright

© 2018 Scandinavian Physiological Society. Published by John Wiley & Sons Ltd.

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Auteurs

Anna C Z Rodrigues (ACZ)

Department of Internal Medicine, Gerontology, Wake Forest School of Medicine, Winston-Salem, North Carolina.
Neuroscience Program, Wake Forest School of Medicine, Winston-Salem, North Carolina.

Maria L Messi (ML)

Department of Internal Medicine, Gerontology, Wake Forest School of Medicine, Winston-Salem, North Carolina.

Zhong-Min Wang (ZM)

Department of Internal Medicine, Gerontology, Wake Forest School of Medicine, Winston-Salem, North Carolina.

Martin C Abba (MC)

Basic and Applied Immunological Research Center (CINIBA), School of Medicine, National University of La Plata, Buenos Aires, Argentina.

Andrea Pereyra (A)

Department of Internal Medicine, Gerontology, Wake Forest School of Medicine, Winston-Salem, North Carolina.

Alexander Birbrair (A)

Department of Internal Medicine, Gerontology, Wake Forest School of Medicine, Winston-Salem, North Carolina.

Tan Zhang (T)

Department of Internal Medicine, Gerontology, Wake Forest School of Medicine, Winston-Salem, North Carolina.

Meaghan O'Meara (M)

Department of Internal Medicine, Gerontology, Wake Forest School of Medicine, Winston-Salem, North Carolina.

Ping Kwan (P)

Department of Internal Medicine, Gerontology, Wake Forest School of Medicine, Winston-Salem, North Carolina.
Neuroscience Program, Wake Forest School of Medicine, Winston-Salem, North Carolina.

Elsa I S Lopez (EIS)

Department of Internal Medicine, Molecular Medicine, Wake Forest School of Medicine, Winston-Salem, North Carolina.

Monte S Willis (MS)

Department of Pathology, McAllister Heart Institute, University of North Carolina-Chapel Hill, Chapel Hill, North Carolina.

Akiva Mintz (A)

Department of Radiology, Wake Forest School of Medicine, Winston-Salem, North Carolina.

D Clark Files (DC)

Department of Internal Medicine, Gerontology, Wake Forest School of Medicine, Winston-Salem, North Carolina.
Department of Internal Medicine, Molecular Medicine, Wake Forest School of Medicine, Winston-Salem, North Carolina.
Department of Internal Medicine, Pulmonary, Wake Forest School of Medicine, Winston-Salem, North Carolina.

Cristina Furdui (C)

Department of Internal Medicine, Molecular Medicine, Wake Forest School of Medicine, Winston-Salem, North Carolina.

Ronald W Oppenheim (RW)

Department of Neurobiology and Anatomy, Wake Forest School of Medicine, Winston-Salem, North Carolina.

Osvaldo Delbono (O)

Department of Internal Medicine, Gerontology, Wake Forest School of Medicine, Winston-Salem, North Carolina.
Neuroscience Program, Wake Forest School of Medicine, Winston-Salem, North Carolina.
ORCID: 0000-0002-1613-8202

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Classifications MeSH

questionsmedicales.fr › Composés chimiques organiques › Amines › Amines biogènes › Acétylcholine › The sympathetic nervous system regulates...
questionsmedicales.fr › Eucaryotes › Animaux › The sympathetic nervous system regulates...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › The sympathetic nervous system regulates...
questionsmedicales.fr › Cellules › Neurones › Neurones efférents › Motoneurones › The sympathetic nervous system regulates...
questionsmedicales.fr › Tissus › Muscles › Muscle strié › Muscles squelettiques › The sympathetic nervous system regulates...
questionsmedicales.fr › États, signes et symptômes pathologiques › Signes et symptômes › Manifestations neurologiques › Manifestations neuromusculaires › Amyotrophie › The sympathetic nervous system regulates...
questionsmedicales.fr › Cellules › Structures cellulaires › Membrane cellulaire › Structures de la membrane cellulaire › Jonctions intercellulaires › Synapses › Synapse neuro-effectrice › Jonction neuromusculaire › The sympathetic nervous system regulates...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Récepteurs de surface cellulaire › Récepteurs aux neuromédiateurs › Récepteurs cholinergiques › The sympathetic nervous system regulates...
questionsmedicales.fr › Système nerveux › Système nerveux périphérique › Système nerveux autonome › Système nerveux sympathique › The sympathetic nervous system regulates...
questionsmedicales.fr › Phénomènes physiologiques de l'appareil locomoteur et du système nerveux › Phénomènes physiologiques du système nerveux › Transmission synaptique › The sympathetic nervous system regulates...