Early-Emerging Sulcal Patterns Are Atypical in Fetuses with Congenital Heart Disease.


Journal

Cerebral cortex (New York, N.Y. : 1991)
ISSN: 1460-2199
Titre abrégé: Cereb Cortex
Pays: United States
ID NLM: 9110718

Informations de publication

Date de publication:
22 07 2019
Historique:
received: 12 01 2018
revised: 28 08 2018
pubmed: 3 10 2018
medline: 16 7 2020
entrez: 2 10 2018
Statut: ppublish

Résumé

Fetuses with congenital heart disease (CHD) have third trimester alterations in cortical development on brain magnetic resonance imaging (MRI). However, the intersulcal relationships contributing to global sulcal pattern remain unknown. This study applied a novel method for examining the geometric and topological relationships between sulci to fetal brain MRIs from 21-30 gestational weeks in CHD fetuses (n = 19) and typically developing (TD) fetuses (n = 17). Sulcal pattern similarity index (SI) to template fetal brain MRIs was determined for the position, area, and depth for corresponding sulcal basins and intersulcal relationships for each subject. CHD fetuses demonstrated altered global sulcal patterns in the left hemisphere compared with TD fetuses (TD [SI, mean ± SD]: 0.822 ± 0.023, CHD: 0.795 ± 0.030, P = 0.002). These differences were present in the earliest emerging sulci and were driven by differences in the position of corresponding sulcal basins (TD: 0.897 ± 0.024, CHD: 0.878 ± 0.019, P = 0.006) and intersulcal relationships (TD: 0.876 ± 0.031, CHD: 0.857 ± 0.018, P = 0.033). No differences in cortical gyrification index, mean curvature, or surface area were present. These data suggest our methods may be more sensitive than traditional measures for evaluating cortical developmental alterations early in gestation.

Identifiants

pubmed: 30272144
pii: 5112934
doi: 10.1093/cercor/bhy235
pmc: PMC6644862
doi:

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

3605-3616

Subventions

Organisme : NHLBI NIH HHS
ID : U10 HL068270
Pays : United States
Organisme : NIBIB NIH HHS
ID : R01 EB013248
Pays : United States
Organisme : NICHD NIH HHS
ID : U54 HD087011
Pays : United States
Organisme : NIBIB NIH HHS
ID : R01 EB017337
Pays : United States
Organisme : NICHD NIH HHS
ID : U01 HD087211
Pays : United States
Organisme : NIBIB NIH HHS
ID : R01 EB018988
Pays : United States
Organisme : NICHD NIH HHS
ID : R21 HD083956
Pays : United States
Organisme : NINDS NIH HHS
ID : K23 NS101120
Pays : United States

Informations de copyright

© The Author(s) 2018. Published by Oxford University Press. All rights reserved. For Permissions, please e-mail: journals.permissions@oup.com.

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Auteurs

Cynthia M Ortinau (CM)

Department of Pediatrics, Washington University in St. Louis, St. Louis, MO, USA.
Department of Pediatric Newborn Medicine, Brigham and Women's Hospital, Boston, MA, USA.

Caitlin K Rollins (CK)

Department of Neurology, Boston Children's Hospital, Boston, MA, USA.
Department of Neurology, Harvard Medical School, Boston, MA, USA.

Ali Gholipour (A)

Department of Radiology, Boston Children's Hospital, Boston, MA, USA.
Department of Radiology, Harvard Medical School, Boston, MA, USA.

Hyuk Jin Yun (HJ)

Fetal Neonatal Neuroimaging and Developmental Science Center, Boston Children's Hospital, Boston, MA, USA.
Department of Pediatrics, Harvard Medical School, Boston, MA, USA.
Division of Newborn Medicine, Boston Children's Hospital Boston, MA, USA.

Mackenzie Marshall (M)

Fetal Neonatal Neuroimaging and Developmental Science Center, Boston Children's Hospital, Boston, MA, USA.

Borjan Gagoski (B)

Department of Radiology, Boston Children's Hospital, Boston, MA, USA.
Department of Radiology, Harvard Medical School, Boston, MA, USA.
Fetal Neonatal Neuroimaging and Developmental Science Center, Boston Children's Hospital, Boston, MA, USA.

Onur Afacan (O)

Department of Radiology, Boston Children's Hospital, Boston, MA, USA.
Department of Radiology, Harvard Medical School, Boston, MA, USA.

Kevin Friedman (K)

Department of Pediatrics, Harvard Medical School, Boston, MA, USA.
Department of Cardiology, Boston Children's Hospital Boston, MA, USA.

Wayne Tworetzky (W)

Department of Pediatrics, Harvard Medical School, Boston, MA, USA.
Department of Cardiology, Boston Children's Hospital Boston, MA, USA.

Simon K Warfield (SK)

Department of Radiology, Boston Children's Hospital, Boston, MA, USA.
Department of Radiology, Harvard Medical School, Boston, MA, USA.

Jane W Newburger (JW)

Department of Pediatrics, Harvard Medical School, Boston, MA, USA.
Department of Cardiology, Boston Children's Hospital Boston, MA, USA.

Terrie E Inder (TE)

Department of Pediatric Newborn Medicine, Brigham and Women's Hospital, Boston, MA, USA.
Department of Pediatrics, Harvard Medical School, Boston, MA, USA.

P Ellen Grant (PE)

Department of Radiology, Boston Children's Hospital, Boston, MA, USA.
Department of Radiology, Harvard Medical School, Boston, MA, USA.
Fetal Neonatal Neuroimaging and Developmental Science Center, Boston Children's Hospital, Boston, MA, USA.
Division of Newborn Medicine, Boston Children's Hospital Boston, MA, USA.

Kiho Im (K)

Fetal Neonatal Neuroimaging and Developmental Science Center, Boston Children's Hospital, Boston, MA, USA.
Department of Pediatrics, Harvard Medical School, Boston, MA, USA.
Division of Newborn Medicine, Boston Children's Hospital Boston, MA, USA.

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Classifications MeSH