Ingestion of soy protein isolate attenuates eccentric contraction-induced force depression and muscle proteolysis via inhibition of calpain-1 activation in rat fast-twitch skeletal muscle.
Ca(2+)-regulatory protein
Calpastatin
N(G)-nitro-l-arginine-methyl ester
Nitric oxide
Plant-based protein
l-arginine
Journal
Nutrition (Burbank, Los Angeles County, Calif.)
ISSN: 1873-1244
Titre abrégé: Nutrition
Pays: United States
ID NLM: 8802712
Informations de publication
Date de publication:
02 2019
02 2019
Historique:
received:
05
03
2018
revised:
13
06
2018
accepted:
24
06
2018
pubmed:
3
10
2018
medline:
23
1
2020
entrez:
2
10
2018
Statut:
ppublish
Résumé
Eccentric contraction (ECC) is a contraction in which skeletal muscles are stretched while contracting. The aim of this study was to determine how ingestion of soy protein isolate (SPI) or animal-based proteins affect force deficit, calpain activation, and proteolysis of calcium ion (Ca In the first experiment, male Wistar rats were randomly assigned to a control and an SPI group, which were fed a 20% casein and a 20% SPI diet, respectively, for 28 d before the ECC protocol. Anterior crural muscles underwent 200 repeated ECCs and were excised 3 d later. In the second experiment, half of the SPI rats were given water containing N SPI ingestion attenuated ECC-induced force deficit, proteolysis of Ca These results suggest that SPI ingestion inhibits ECC-elicited force deficit and proteolysis of Ca
Identifiants
pubmed: 30273822
pii: S0899-9007(18)30624-5
doi: 10.1016/j.nut.2018.06.025
pii:
doi:
Substances chimiques
Soybean Proteins
0
Calpain
EC 3.4.22.-
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
23-29Informations de copyright
Copyright © 2019 Elsevier Ltd. All rights reserved.