The regenerating family member 3 β instigates IL-17A-mediated neutrophil recruitment downstream of NOD1/2 signalling for controlling colonisation resistance independently of microbiota community structure.

Animals CARD Signaling Adaptor Proteins / physiology Citrobacter rodentium Crohn Disease / microbiology Disease Models, Animal Enterobacteriaceae Infections / pathology Interleukin-17 / physiology Intestinal Mucosa / pathology Mice Neutrophil Infiltration / physiology Nod2 Signaling Adaptor Protein / physiology Receptor-Interacting Protein Serine-Threonine Kinase 2 Receptor-Interacting Protein Serine-Threonine Kinases / physiology Signal Transduction
Antibacterial Peptide Barrier Function Colonic Microflora Interleukins Macrophages

Journal

Gut
ISSN: 1468-3288
Titre abrégé: Gut
Pays: England
ID NLM: 2985108R

Informations de publication

Date de publication:
07 2019
Historique:
received: 07 05 2018
revised: 08 08 2018
accepted: 29 08 2018
pubmed: 4 10 2018
medline: 28 7 2019
entrez: 4 10 2018
Statut: ppublish

Résumé

Loss of the Crohn's disease predisposing Colonisation resistance was evaluated in wild type and mutant mice, as well as in ex-germ-free (ex-GF) mice which were colonised either with faeces from Primary infection was similarly outcompeted in ex-GF These results unveil a previously unrecognised mechanism that efficiently protects from colonisation by diarrhoeagenic bacteria early in infection.

Identifiants

DOI: 10.1136/gutjnl-2018-316757 PMID: 30279238
pubmed: 30279238
pii: gutjnl-2018-316757
doi: 10.1136/gutjnl-2018-316757
doi:

Substances chimiques

CARD Signaling Adaptor Proteins 0
Card9 protein, mouse 0
Il17a protein, mouse 0
Interleukin-17 0
Nod2 Signaling Adaptor Protein 0
Nod2 protein, mouse 0
Receptor-Interacting Protein Serine-Threonine Kinase 2 EC 2.7.11.1
Receptor-Interacting Protein Serine-Threonine Kinases EC 2.7.11.1
Ripk2 protein, mouse EC 2.7.11.1

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Pagination

1190-1199

Informations de copyright

© Author(s) (or their employer(s)) 2019. No commercial re-use. See rights and permissions. Published by BMJ.

Déclaration de conflit d'intérêts

Competing interests: None declared.

Auteurs

Nadine Waldschmitt (N)

CIIL - Centre d'Infection et d'Immunité de Lille, Université de Lille, CNRS, Inserm, CHRU Lille, Institut Pasteur de Lille, U1019 - UMR 8204, F-59000, Lille, France.

Sho Kitamoto (S)

Division of Gastroenterology, Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, Michigan, USA.

Thomas Secher (T)

INEM, Orléans University, CNRS UMR 7355, F-45071, Orléans, France.

Vassiliki Zacharioudaki (V)

CIIL - Centre d'Infection et d'Immunité de Lille, Université de Lille, CNRS, Inserm, CHRU Lille, Institut Pasteur de Lille, U1019 - UMR 8204, F-59000, Lille, France.

Olivier Boulard (O)

CIIL - Centre d'Infection et d'Immunité de Lille, Université de Lille, CNRS, Inserm, CHRU Lille, Institut Pasteur de Lille, U1019 - UMR 8204, F-59000, Lille, France.

Emilie Floquet (E)

CIIL - Centre d'Infection et d'Immunité de Lille, Université de Lille, CNRS, Inserm, CHRU Lille, Institut Pasteur de Lille, U1019 - UMR 8204, F-59000, Lille, France.

Myriam Delacre (M)

CIIL - Centre d'Infection et d'Immunité de Lille, Université de Lille, CNRS, Inserm, CHRU Lille, Institut Pasteur de Lille, U1019 - UMR 8204, F-59000, Lille, France.

Bruno Lamas (B)

Laboratoire des Biomolécules (LBM), SorbonneUniversités, UPMC Univ. Paris 06, École normale supérieure, PSL ResearchUniversity, CNRS, INSERM, APHP, Paris, France.
Commensals and Probiotics-Host Interactions Laboratory, INRA, UMR1319Micalis & AgroParisTech, Jouy-en-Josas, France.

Hang-Phuong Pham (HP)

ILTOO Pharma, iPEPS ICM, Hôpital Pitié Salpêtrière, Paris, France.

Adrien Six (A)

Department of Immunology-Immunopathology-Immunotherapy (I3), Sorbonne Universités, UPMC Univ Paris 06, Inserm UMRS959, Paris, France.

Mathias L Richard (ML)

Commensals and Probiotics-Host Interactions Laboratory, INRA, UMR1319Micalis & AgroParisTech, Jouy-en-Josas, France.

Jean-Charles Dagorn (JC)

Centre de Recherche en Cancérologie de Marseille, Aix-Marseille Université, Inserm U1068, CNRS UMR 7258 and Institut Paoli-Calmettes, Parc Scientifique et Technologique de Luminy, Marseille, France.

Gérard Eberl (G)

Microenvironment and Immunity Unit, Institut Pasteur, Paris, France.

Philippe Langella (P)

Commensals and Probiotics-Host Interactions Laboratory, INRA, UMR1319Micalis & AgroParisTech, Jouy-en-Josas, France.

Jean-Marc Chatel (JM)

Commensals and Probiotics-Host Interactions Laboratory, INRA, UMR1319Micalis & AgroParisTech, Jouy-en-Josas, France.

Bernhard Ryffel (B)

INEM, Orléans University, CNRS UMR 7355, F-45071, Orléans, France.

Juan Lucio Iovanna (JL)

Centre de Recherche en Cancérologie de Marseille, Aix-Marseille Université, Inserm U1068, CNRS UMR 7258 and Institut Paoli-Calmettes, Parc Scientifique et Technologique de Luminy, Marseille, France.

Lionel F Poulin (LF)

CIIL - Centre d'Infection et d'Immunité de Lille, Université de Lille, CNRS, Inserm, CHRU Lille, Institut Pasteur de Lille, U1019 - UMR 8204, F-59000, Lille, France.

Harry Sokol (H)

Laboratoire des Biomolécules (LBM), SorbonneUniversités, UPMC Univ. Paris 06, École normale supérieure, PSL ResearchUniversity, CNRS, INSERM, APHP, Paris, France.
Commensals and Probiotics-Host Interactions Laboratory, INRA, UMR1319Micalis & AgroParisTech, Jouy-en-Josas, France.
Department of Gastroenterology, Saint Antoine Hospital, AP-HP, UPMC Univ Paris 06, Paris, France.

Nobuhiko Kamada (N)

Division of Gastroenterology, Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, Michigan, USA.

Mathias Chamaillard (M)

CIIL - Centre d'Infection et d'Immunité de Lille, Université de Lille, CNRS, Inserm, CHRU Lille, Institut Pasteur de Lille, U1019 - UMR 8204, F-59000, Lille, France.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › The regenerating family member 3 β instigates...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines et peptides de signalisation intracellulaire › Protéines régulatrices de l'apoptose › Protéines adaptatrices de signalisation CARD › The regenerating family member 3 β instigates...
questionsmedicales.fr › Bactéries › Proteobacteria › Gammaproteobacteria › Enterobacteriaceae › Citrobacter › Citrobacter rodentium › The regenerating family member 3 β instigates...
questionsmedicales.fr › Maladies de l'appareil digestif › Maladies gastro-intestinales › Maladies intestinales › Maladies inflammatoires intestinales › Maladie de Crohn › The regenerating family member 3 β instigates...
questionsmedicales.fr › Techniques d'investigation › Modèles théoriques › Modèles biologiques › Modèles animaux de maladie humaine › The regenerating family member 3 β instigates...
questionsmedicales.fr › Infection › Infections bactériennes et mycoses › Infections bactériennes › Infections bactériennes à Gram négatif › Infections à Enterobacteriaceae › The regenerating family member 3 β instigates...
questionsmedicales.fr › Facteurs biologiques › Protéines et peptides de signalisation intercellulaire › Cytokines › Interleukines › Interleukine-17 › The regenerating family member 3 β instigates...
questionsmedicales.fr › Tissus › Membranes › Muqueuse › Muqueuse intestinale › The regenerating family member 3 β instigates...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › The regenerating family member 3 β instigates...
questionsmedicales.fr › Phénomènes du système immunitaire › Infiltration par les neutrophiles › The regenerating family member 3 β instigates...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines et peptides de signalisation intracellulaire › Protéines régulatrices de l'apoptose › Protéines adaptatrices de signalisation CARD › Protéine adaptatrice de signalisation NOD2 › The regenerating family member 3 β instigates...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines et peptides de signalisation intracellulaire › Protein-Serine-Threonine Kinases › Receptor-Interacting Protein Serine-Threonine Kinases › Receptor-Interacting Protein Serine-Threonine Kinase 2 › The regenerating family member 3 β instigates...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines et peptides de signalisation intracellulaire › Protein-Serine-Threonine Kinases › Receptor-Interacting Protein Serine-Threonine Kinases › The regenerating family member 3 β instigates...
questionsmedicales.fr › Phénomènes physiologiques cellulaires › Transduction du signal › The regenerating family member 3 β instigates...