The role of the cerebellum in drug-cue associative memory: functional interactions with the medial prefrontal cortex.
Animals
Association Learning
/ drug effects
Cerebellum
/ drug effects
Cocaine
/ administration & dosage
Conditioning, Classical
/ drug effects
Cues
Dopamine Uptake Inhibitors
/ administration & dosage
Injections, Intraventricular
Male
Memory
/ drug effects
Neural Pathways
/ drug effects
Prefrontal Cortex
/ drug effects
Rats
Rats, Sprague-Dawley
cocaine
drug-induced conditioning
lidocaine
odours
quinolinic acid
Journal
The European journal of neuroscience
ISSN: 1460-9568
Titre abrégé: Eur J Neurosci
Pays: France
ID NLM: 8918110
Informations de publication
Date de publication:
08 2019
08 2019
Historique:
received:
28
02
2018
revised:
14
06
2018
accepted:
28
06
2018
pubmed:
4
10
2018
medline:
8
8
2020
entrez:
4
10
2018
Statut:
ppublish
Résumé
Drug-induced Pavlovian memories are thought to be crucial for drug addiction because they guide behaviour towards environments with drug availability. Drug-related memory depends on persistent changes in dopamine-glutamate interactions in the medial prefrontal cortex (mPFC), basolateral amygdala, nucleus accumbens core and hippocampus. Recent evidence from our laboratory indicated that the cerebellum is also a relevant node for drug-cue associations. In the present study, we tested the role that specific regions of the cerebellum and mPFC play in the acquisition of cocaine-induced preference conditioning. Quinolinic acid was used to manage a permanent deactivation of lobule VIII in the vermis prior to conditioning. Additionally, lidocaine was infused into the prelimbic and infralimbic (IL) cortices for reversible deactivation before every training session. The present findings show, for the first time, that the cerebellum and mPFC might act together in order to acquire drug-cue Pavlovian associations. Either a dorsal lesion in lobule VIII or an IL deactivation encouraged cocaine-induced preference conditioning. Moreover, simultaneous IL-cerebellar deactivation prevented the effect of either of the separate deactivations. Therefore, similar to the IL cortex, neural activity in the cerebellum may be crucial for ensuring inhibitory control of the expression of cocaine-related memories.
Substances chimiques
Dopamine Uptake Inhibitors
0
Cocaine
I5Y540LHVR
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
2613-2622Subventions
Organisme : Universitat Jaume I
ID : PREDOC2014/11
Pays : International
Organisme : Universitat Jaume I
ID : UJI (14I307.01/1)
Pays : International
Organisme : Ministerio de Educación Cultura y Deporte
ID : (FPU12/04059)
Pays : International
Organisme : Plan Nacional de Drogas 2017
ID : (PND-132400)
Pays : International
Organisme : Ministerio de Economía y Competitividad
ID : PSI2015-68600-P
Pays : International
Informations de copyright
© 2018 Federation of European Neuroscience Societies and John Wiley & Sons Ltd.
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