T-lymphocyte-specific knockout of IKK-2 or NEMO induces T
Animals
Cells, Cultured
Cytokines
/ metabolism
Disease Models, Animal
I-kappa B Kinase
/ physiology
Intracellular Signaling Peptides and Proteins
/ physiology
Male
Mice
Mice, Knockout
NF-kappa B
/ genetics
Nephritis
/ chemically induced
Phosphorylation
Signal Transduction
T-Lymphocytes
/ metabolism
Th17 Cells
/ immunology
NF-κB
NTN
canonical/noncanonical pathway
transcription factors
transcriptome
Journal
FASEB journal : official publication of the Federation of American Societies for Experimental Biology
ISSN: 1530-6860
Titre abrégé: FASEB J
Pays: United States
ID NLM: 8804484
Informations de publication
Date de publication:
02 2019
02 2019
Historique:
pubmed:
5
10
2018
medline:
27
8
2019
entrez:
5
10
2018
Statut:
ppublish
Résumé
Experimental nephrotoxic serum nephritis (NTN) is a model for T-cell-mediated human rapid progressive glomerulonephritis. T-cell receptor stimulation involves intracellular signaling events that ultimately lead to the activation of transcription factors, such as NF-κB. We explored the involvement of the NF-κB components IKK-2 and NEMO in NTN, by using cell-specific knockouts of IKK-2 and NEMO in CD4
Identifiants
pubmed: 30285578
doi: 10.1096/fj.201800485RR
doi:
Substances chimiques
Cytokines
0
Intracellular Signaling Peptides and Proteins
0
NEMO protein, mouse
0
NF-kappa B
0
I-kappa B Kinase
EC 2.7.11.10
Ikbkb protein, mouse
EC 2.7.11.10
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng