Hyperglycosylated hCG activates LH/hCG-receptor with lower activity than hCG.

Animals Chorionic Gonadotropin / pharmacology Chorionic Gonadotropin, beta Subunit, Human / pharmacology Dogs Glycosylation Humans Luteinizing Hormone / metabolism Madin Darby Canine Kidney Cells Receptors, LH / metabolism
Hyperglycosylated hCG LH/hCG receptor LHCGR Reporter system hCG

Journal

Molecular and cellular endocrinology
ISSN: 1872-8057
Titre abrégé: Mol Cell Endocrinol
Pays: Ireland
ID NLM: 7500844

Informations de publication

Date de publication:
05 01 2019
Historique:
received: 03 07 2018
revised: 13 08 2018
accepted: 22 09 2018
pubmed: 6 10 2018
medline: 16 5 2019
entrez: 6 10 2018
Statut: ppublish

Résumé

While human chorionic gonadotropin (hCG) appears to have an essential role in early pregnancy, it is controversial whether the hyperglycosylated form of hCG (hCG-h), which is the major hCG isoform during the first 4-5 weeks of pregnancy, is able to activate LH/hCG receptor (LHCGR). To address this, we utilized different extensively characterized hCG and hCGβ reference reagents, cell culture- and urine-derived hCG-h preparations, and an in vitro reporter system for LHCGR activation. The WHO hCG reference reagent (99/688) was found to activate LHCGR with an EC

Identifiants

DOI: 10.1016/j.mce.2018.09.006 PMID: 30287399
pubmed: 30287399
pii: S0303-7207(18)30276-4
doi: 10.1016/j.mce.2018.09.006
pii:
doi:

Substances chimiques

Chorionic Gonadotropin 0
Chorionic Gonadotropin, beta Subunit, Human 0
Receptors, LH 0
Luteinizing Hormone 9002-67-9

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

103-109

Informations de copyright

Copyright © 2018 The Author(s). Published by Elsevier B.V. All rights reserved.

Auteurs

Hannu Koistinen (H)

Department of Clinical Chemistry, University of Helsinki and Helsinki University Hospital, Helsinki, Finland. Electronic address: hannu.k.koistinen@helsinki.fi.

Mariann Koel (M)

Competence Centre on Health Technologies, Tartu, Estonia; Department of Cell Biology, Institute of Molecular and Cell Biology, University of Tartu, Tartu, Estonia.

Maire Peters (M)

Competence Centre on Health Technologies, Tartu, Estonia; Department of Obstetrics and Gynaecology, Institute of Clinical Medicine, University of Tartu, Tartu, Estonia.

Ago Rinken (A)

Institute of Chemistry, University of Tartu, Tartu, Estonia.

Karolina Lundin (K)

Department of Obstetrics and Gynecology, University of Helsinki and Helsinki University Hospital, Helsinki, Finland.

Timo Tuuri (T)

Department of Obstetrics and Gynecology, University of Helsinki and Helsinki University Hospital, Helsinki, Finland.

Juha S Tapanainen (JS)

Department of Obstetrics and Gynecology, University of Helsinki and Helsinki University Hospital, Helsinki, Finland; Department of Obstetrics and Gynecology, University Hospital of Oulu, University of Oulu, Medical Research Center Oulu and PEDEGO Research Unit, Oulu, Finland.

Henrik Alfthan (H)

Department of Clinical Chemistry, University of Helsinki and Helsinki University Hospital, Helsinki, Finland.

Andres Salumets (A)

Competence Centre on Health Technologies, Tartu, Estonia; Department of Obstetrics and Gynaecology, Institute of Clinical Medicine, University of Tartu, Tartu, Estonia; Department of Obstetrics and Gynecology, University of Helsinki and Helsinki University Hospital, Helsinki, Finland; Institute of Biomedicine and Translational Medicine, University of Tartu, Tartu, Estonia.

Ulf-Håkan Stenman (UH)

Department of Clinical Chemistry, University of Helsinki and Helsinki University Hospital, Helsinki, Finland.

Darja Lavogina (D)

Competence Centre on Health Technologies, Tartu, Estonia; Institute of Chemistry, University of Tartu, Tartu, Estonia.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Hyperglycosylated hCG activates...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines de la grossesse › Gonadotrophine chorionique › Hyperglycosylated hCG activates...
questionsmedicales.fr › Facteurs biologiques › Marqueurs biologiques › Sous-unité bêta de la gonadotrophine chorionique humaine › Hyperglycosylated hCG activates...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Carnivora › Pinnipedia › Canidae › Chiens › Hyperglycosylated hCG activates...
questionsmedicales.fr › Métabolisme › Métabolisme glucidique › Glycosylation › Hyperglycosylated hCG activates...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Hyperglycosylated hCG activates...
questionsmedicales.fr › Acides aminés, peptides et protéines › Peptides › Hormones peptidiques › Hormones hypophysaires › Hormones antéhypophysaires › Gonadotrophines hypophysaires › Hormone lutéinisante › Hyperglycosylated hCG activates...
questionsmedicales.fr › Cellules › Cellules épithéliales › Cellules rénales canines Madin-Darby › Hyperglycosylated hCG activates...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Récepteurs de surface cellulaire › Récepteurs peptidiques › Récepteur hormone hypophysaire › Récepteur gonadotrophine › Récepteur LH › Hyperglycosylated hCG activates...