Proteomics of neurodegenerative diseases: analysis of human post-mortem brain.
Alzheimer Disease
/ complications
Amyotrophic Lateral Sclerosis
/ complications
Biomarkers
/ metabolism
Brain
/ metabolism
Dementia
/ complications
Disease Progression
Frontotemporal Dementia
/ complications
Humans
Neurodegenerative Diseases
/ complications
Parkinson Disease
/ complications
Proteome
/ metabolism
Proteomics
Alzheimer's disease
brain
dementia
mass spectrometer
neuroproteomics
Journal
Journal of neurochemistry
ISSN: 1471-4159
Titre abrégé: J Neurochem
Pays: England
ID NLM: 2985190R
Informations de publication
Date de publication:
11 2019
11 2019
Historique:
received:
05
06
2018
revised:
15
08
2018
accepted:
01
10
2018
pubmed:
6
10
2018
medline:
6
5
2020
entrez:
6
10
2018
Statut:
ppublish
Résumé
Dementias are prevalent brain disorders in the aged population. Dementias pose major socio-medical burden, but currently there is no cure available. Novel proteomics approaches hold promise to identify alterations of the brain proteome that could provide clues on disease etiology, and identify candidate proteins to develop further as a biomarker. In this review, we focus on recent proteomics findings from brains affected with Alzheimer's Disease, Parkinson Disease Dementia, Frontotemporal Dementia, and Amyotrophic Lateral Sclerosis. These studies confirmed known cellular changes, and in addition identified novel proteins that may underlie distinct aspects of the diseases. This article is part of the special issue "Proteomics".
Identifiants
pubmed: 30289976
doi: 10.1111/jnc.14603
pmc: PMC6899881
doi:
Substances chimiques
Biomarkers
0
Proteome
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
435-445Informations de copyright
© 2018 The Authors. Journal of Neurochemistry published by John Wiley & Sons Ltd on behalf of International Society for Neurochemistry.
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