Overexpression of Desmoglein 2 in a Mouse Model of Gorlin Syndrome Enhances Spontaneous Basal Cell Carcinoma Formation through STAT3-Mediated Gli1 Expression.

Animals Basal Cell Nevus Syndrome / genetics Cell Line, Tumor Desmoglein 2 / metabolism Disease Models, Animal Gene Knock-In Techniques Hedgehog Proteins / metabolism Humans Mice Mice, Transgenic Patched-1 Receptor / genetics Phosphorylation STAT3 Transcription Factor / antagonists & inhibitors Skin / pathology Skin Neoplasms / genetics Zinc Finger Protein GLI1 / metabolism

Journal

The Journal of investigative dermatology
ISSN: 1523-1747
Titre abrégé: J Invest Dermatol
Pays: United States
ID NLM: 0426720

Informations de publication

Date de publication:
02 2019
Historique:
received: 10 01 2018
revised: 03 09 2018
accepted: 04 09 2018
pubmed: 7 10 2018
medline: 1 1 2020
entrez: 7 10 2018
Statut: ppublish

Résumé

Activation of the hedgehog pathway is causative of virtually all sporadic and Gorlin syndrome-related basal cell carcinomas (BCCs), with loss of function of Ptc1 being the most common genomic lesion. Sporadic BCCs also overexpress Dsg2, a desmosomal cadherin normally found in the basal layer. Using a mouse model of Gorlin syndrome (Ptc1

Identifiants

DOI: 10.1016/j.jid.2018.09.009 PMID: 30291846 PMC: PMC6342634
pubmed: 30291846
pii: S0022-202X(18)32647-2
doi: 10.1016/j.jid.2018.09.009
pmc: PMC6342634
mid: NIHMS1508756
pii:
doi:

Substances chimiques

DSG2 protein, human 0
Desmoglein 2 0
Dsg2 protein, mouse 0
GLI1 protein, human 0
Gli1 protein, mouse 0
Hedgehog Proteins 0
PTCH1 protein, human 0
Patched-1 Receptor 0
Ptch1 protein, mouse 0
STAT3 Transcription Factor 0
STAT3 protein, human 0
Stat3 protein, mouse 0
Zinc Finger Protein GLI1 0

Types de publication

Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

300-307

Subventions

Organisme : NCI NIH HHS
ID : F31 CA171680
Pays : United States
Organisme : NIAMS NIH HHS
ID : R01 AR056067
Pays : United States
Organisme : NIAMS NIH HHS
ID : T32 AR007465
Pays : United States
Organisme : CIHR
Pays : Canada

Informations de copyright

Copyright © 2018 The Authors. Published by Elsevier Inc. All rights reserved.

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Auteurs

Donna M Brennan-Crispi (DM)

Department of Biochemistry and Molecular Biology, Thomas Jefferson University, Philadelphia, Pennsylvania, USA; Department of Dermatology and Cutaneous Biology, Thomas Jefferson University, Philadelphia, Pennsylvania, USA; Sydney Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, Pennsylvania, USA; Biochemistry and Pharmacology Graduate Program, Thomas Jefferson University, Philadelphia, Pennsylvania, USA.

Andrew M Overmiller (AM)

Department of Dermatology and Cutaneous Biology, Thomas Jefferson University, Philadelphia, Pennsylvania, USA; Biochemistry and Pharmacology Graduate Program, Thomas Jefferson University, Philadelphia, Pennsylvania, USA.

Lukas Tamayo-Orrego (L)

Molecular Biology of Neural Development, Institut de Recherches Cliniques de Montréal (IRCM) Montreal, Quebec, Canada; Integrated Program in Neuroscience, McGill University, Montreal, Quebec, Canada.

Molly R Marous (MR)

Department of Dermatology and Cutaneous Biology, Thomas Jefferson University, Philadelphia, Pennsylvania, USA.

Joya Sahu (J)

Department of Dermatology and Cutaneous Biology, Thomas Jefferson University, Philadelphia, Pennsylvania, USA.

Kathleen P McGuinn (KP)

Department of Dermatology and Cutaneous Biology, Thomas Jefferson University, Philadelphia, Pennsylvania, USA.

Felicia Cooper (F)

Department of Dermatology and Cutaneous Biology, Thomas Jefferson University, Philadelphia, Pennsylvania, USA.

Ioanna Ch Georgiou (IC)

Leeds Institute of Cancer and Pathology, University of Leeds, UK; School of Molecular and Cellular Biology, University of Leeds, United Kingdom.

Maxwell Frankfurter (M)

Department of Dermatology, University of Pennsylvania, Philadelphia, Pennsylvania, USA.

Julio C Salas-Alanis (JC)

Center for Molecular Diagnostics and Personalized Medicine, University of Monterrey, Mexico.

Frédéric Charron (F)

Molecular Biology of Neural Development, Institut de Recherches Cliniques de Montréal (IRCM) Montreal, Quebec, Canada; Integrated Program in Neuroscience, McGill University, Montreal, Quebec, Canada; Department of Biology, Department of Anatomy and Cell Biology, and Department of Medicine, McGill University, Montreal, Quebec, Canada; Department of Medicine, University of Montreal, Montreal, Quebec, Canada.

Sarah E Millar (SE)

Department of Dermatology, University of Pennsylvania, Philadelphia, Pennsylvania, USA.

Mỹ G Mahoney (MG)

Department of Dermatology and Cutaneous Biology, Thomas Jefferson University, Philadelphia, Pennsylvania, USA; Sydney Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, Pennsylvania, USA. Electronic address: My.Mahoney@jefferson.edu.

Natalia A Riobo-Del Galdo (NA)

Department of Biochemistry and Molecular Biology, Thomas Jefferson University, Philadelphia, Pennsylvania, USA; Sydney Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, Pennsylvania, USA; Leeds Institute of Cancer and Pathology, University of Leeds, UK; School of Molecular and Cellular Biology, University of Leeds, United Kingdom. Electronic address: N.A.Riobo-DelGaldo@leeds.ac.uk.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Overexpression of Desmoglein 2 in a Mouse...
questionsmedicales.fr › Malformations et maladies congénitales, héréditaires et néonatales › Maladies génétiques congénitales › Syndromes néoplasiques héréditaires › Naevomatose basocellulaire › Overexpression of Desmoglein 2 in a Mouse...
questionsmedicales.fr › Cellules › Cellules cultivées › Cellules cancéreuses en culture › Lignée cellulaire tumorale › Overexpression of Desmoglein 2 in a Mouse...
questionsmedicales.fr › Facteurs biologiques › Antigènes › Antigènes de surface › Molécules d'adhérence cellulaire › Cadhérines › Cadhérines des desmosomes › Desmogléines › Desmogléine-2 › Overexpression of Desmoglein 2 in a Mouse...
questionsmedicales.fr › Techniques d'investigation › Modèles théoriques › Modèles biologiques › Modèles animaux de maladie humaine › Overexpression of Desmoglein 2 in a Mouse...
questionsmedicales.fr › Techniques d'investigation › Techniques génétiques › Ciblage de gène › Techniques de knock-in de gènes › Overexpression of Desmoglein 2 in a Mouse...
questionsmedicales.fr › Facteurs biologiques › Protéines et peptides de signalisation intercellulaire › Protéines Hedgehog › Overexpression of Desmoglein 2 in a Mouse...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Overexpression of Desmoglein 2 in a Mouse...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Overexpression of Desmoglein 2 in a Mouse...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Souris transgéniques › Overexpression of Desmoglein 2 in a Mouse...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines tumorales › Protéines suppresseurs de tumeurs › Récepteurs patched › Récepteur Patched-1 › Overexpression of Desmoglein 2 in a Mouse...
questionsmedicales.fr › Métabolisme › Phosphorylation › Overexpression of Desmoglein 2 in a Mouse...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Facteurs de transcription › Facteurs de transcription STAT › Facteur de transcription STAT-3 › Overexpression of Desmoglein 2 in a Mouse...
questionsmedicales.fr › Système tégumentaire › Peau › Overexpression of Desmoglein 2 in a Mouse...
questionsmedicales.fr › Maladies de la peau et du tissu conjonctif › Maladies de la peau › Tumeurs cutanées › Overexpression of Desmoglein 2 in a Mouse...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Facteurs de transcription › Protéine à doigt de zinc GLI1 › Overexpression of Desmoglein 2 in a Mouse...