Risky decision-making is associated with impulsive action and sensitivity to first-time nicotine exposure.
Anxiety
Habit formation
Impulsivity
Nicotine
Risky decision-making
Substance use disorders
Journal
Behavioural brain research
ISSN: 1872-7549
Titre abrégé: Behav Brain Res
Pays: Netherlands
ID NLM: 8004872
Informations de publication
Date de publication:
01 02 2019
01 02 2019
Historique:
received:
13
07
2018
revised:
04
10
2018
accepted:
04
10
2018
pubmed:
9
10
2018
medline:
24
4
2019
entrez:
9
10
2018
Statut:
ppublish
Résumé
Excessive risk-taking is common in multiple psychiatric conditions, including substance use disorders. The risky decision-making task (RDT) models addiction-relevant risk-taking in rats by measuring preference for a small food reward vs. a large food reward associated with systematically increasing risk of shock. Here, we examined the relationship between risk-taking in the RDT and multiple addiction-relevant phenotypes. Risk-taking was associated with elevated impulsive action, but not impulsive choice or habit formation. Furthermore, risk-taking predicted locomotor sensitivity to first-time nicotine exposure and resilience to nicotine-evoked anxiety. These data demonstrate that risk preference in the RDT predicts other traits associated with substance use disorder, and may have utility for identification of neurobiological and genetic biomarkers that engender addiction vulnerability.
Identifiants
pubmed: 30296531
pii: S0166-4328(18)31011-8
doi: 10.1016/j.bbr.2018.10.008
pii:
doi:
Substances chimiques
Nicotinic Agonists
0
Nicotine
6M3C89ZY6R
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
579-588Informations de copyright
Published by Elsevier B.V.