Plasma and interstitial fluid population pharmacokinetics of vancomycin in critically ill patients with sepsis.
Adult
Aged
Anti-Bacterial Agents
/ pharmacokinetics
Critical Illness
Extracellular Fluid
/ chemistry
Female
Humans
Intensive Care Units
Male
Methicillin-Resistant Staphylococcus aureus
/ drug effects
Middle Aged
Plasma
/ chemistry
Prospective Studies
Sepsis
/ drug therapy
Staphylococcal Infections
/ drug therapy
Vancomycin
/ blood
Antimicrobial
Dosing
Microdialysis
Pharmacodynamics
Septic shock
Journal
International journal of antimicrobial agents
ISSN: 1872-7913
Titre abrégé: Int J Antimicrob Agents
Pays: Netherlands
ID NLM: 9111860
Informations de publication
Date de publication:
Feb 2019
Feb 2019
Historique:
received:
27
01
2018
revised:
26
09
2018
accepted:
29
09
2018
pubmed:
9
10
2018
medline:
17
5
2019
entrez:
9
10
2018
Statut:
ppublish
Résumé
Vancomycin is a commonly prescribed antibiotic in the intensive care unit. However, there are limited data describing its distribution into the interstitial fluid (ISF) of tissues. The aim of this study was to describe the plasma and tissue ISF population pharmacokinetics of vancomycin in critically ill patients with sepsis. Serial vancomycin blood and ISF samples were collected at pre-specified time intervals in critically ill patients with sepsis. ISF sampling occurred using a subcutaneously inserted microdialysis catheter. Bioanalysis was undertaken using a validated spectrometric assay method. Population pharmacokinetic analysis was performed using Pmetrics
Identifiants
pubmed: 30296581
pii: S0924-8579(18)30280-2
doi: 10.1016/j.ijantimicag.2018.09.021
pii:
doi:
Substances chimiques
Anti-Bacterial Agents
0
Vancomycin
6Q205EH1VU
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
137-142Informations de copyright
Copyright © 2018 Elsevier Ltd. All rights reserved.