Combined antifungal therapy is superior to monotherapy in pulmonary scedosporiosis in cystic fibrosis.
Adult
Antifungal Agents
/ administration & dosage
Cystic Fibrosis
/ complications
Drug Monitoring
/ methods
Drug Therapy, Combination
/ methods
Female
Germany
Humans
Invasive Fungal Infections
/ diagnosis
Lung
/ diagnostic imaging
Lung Diseases, Fungal
/ diagnosis
Male
Outcome and Process Assessment, Health Care
Respiratory Function Tests
/ methods
Scedosporium
/ drug effects
Tomography, X-Ray Computed
/ methods
Anti-fungal treatment
Mycosis
Pneumonia
Journal
Journal of cystic fibrosis : official journal of the European Cystic Fibrosis Society
ISSN: 1873-5010
Titre abrégé: J Cyst Fibros
Pays: Netherlands
ID NLM: 101128966
Informations de publication
Date de publication:
03 2019
03 2019
Historique:
received:
07
04
2018
revised:
06
08
2018
accepted:
31
08
2018
pubmed:
10
10
2018
medline:
17
7
2020
entrez:
10
10
2018
Statut:
ppublish
Résumé
Cystic fibrosis (CF) is characterised by chronic airway infection with bacteria and fungi. Infections caused by Scedosporium/Lomentospora species can occur and are difficult to treat. Moulds belonging to the genus Scedosporium/Lomentospora are detected most frequently in respiratory samples of patients with CF, next to Aspergillus spp. Our aim was to define pulmonary fungal infections due to Scedosporium/Lomentospora in CF and to study the antimycotic treatment. In this multicentre study (12 centres; duration January 2008 to December 2014) 31 patients with a lung infection caused by moulds of the genus Scedosporium/Lomentospora were included. 36 courses of antifungal treatment were documented. Scedosporium apiospermum sensu stricto accounted for 48.4% of cases. In 20/31 patients a therapeutic response under antimycotics (median duration 3.9 months) was achieved. Triple and double therapy was significantly more effective compared to monotherapy regarding FEV
Identifiants
pubmed: 30297214
pii: S1569-1993(18)30794-X
doi: 10.1016/j.jcf.2018.08.012
pii:
doi:
Substances chimiques
Antifungal Agents
0
Types de publication
Journal Article
Multicenter Study
Langues
eng
Sous-ensembles de citation
IM
Pagination
227-232Informations de copyright
Copyright © 2018 European Cystic Fibrosis Society. Published by Elsevier B.V. All rights reserved.