Smoking-induced changes in leptin serum levels and c/EBPalpha-related methylation status of the leptin core promotor during smoking cessation.
Adult
Binding Sites
/ genetics
CCAAT-Enhancer-Binding Protein-alpha
/ metabolism
Case-Control Studies
Craving
/ physiology
DNA Methylation
Epigenesis, Genetic
/ physiology
Female
Humans
Leptin
/ blood
Male
Pilot Projects
Promoter Regions, Genetic
Smoking
/ blood
Smoking Cessation
Substance Withdrawal Syndrome
/ blood
Tobacco Use Disorder
/ blood
Young Adult
Craving
Epigenetics
Leptin
Tobacco dependence
Journal
Psychoneuroendocrinology
ISSN: 1873-3360
Titre abrégé: Psychoneuroendocrinology
Pays: England
ID NLM: 7612148
Informations de publication
Date de publication:
02 2019
02 2019
Historique:
received:
12
06
2018
revised:
14
09
2018
accepted:
16
09
2018
pubmed:
10
10
2018
medline:
25
3
2020
entrez:
10
10
2018
Statut:
ppublish
Résumé
Previous studies have provided evidence of an association between serum leptin levels and smoking as well as craving during smoking cessation. As promoter methylation also regulates leptin expression, we investigated the leptin gene promoter region of smokers before and after smoking cessation. Since leptin's core promoter region contains an essential c/EBPalpha transcription binding site, we narrowed our investigation to C-300 (-300 base pairs from the transcription start site) of that binding site. Female smokers showed hypermethylation of C-300 compared to non-smokers. Global methylation status is associated with higher craving and the degree of dependence in female smokers. Serum leptin levels in female smokers were significantly higher than in non-smokers. These findings support previous results and, for the first time, point to a pathophysiological role of c/EBPalpha-related C-300 methylation in tobacco dependence.
Identifiants
pubmed: 30299257
pii: S0306-4530(18)30598-5
doi: 10.1016/j.psyneuen.2018.09.022
pii:
doi:
Substances chimiques
CCAAT-Enhancer-Binding Protein-alpha
0
Leptin
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
106-112Informations de copyright
Copyright © 2018 Elsevier Ltd. All rights reserved.