Adenocarcinoma, Mucinous
/ genetics
Animals
Cell Line, Tumor
Cell Survival
DEAD-box RNA Helicases
/ metabolism
Drug Resistance, Neoplasm
Female
Gene Expression Regulation, Neoplastic
Gene Knockdown Techniques
Humans
Mice
MicroRNAs
/ genetics
Ovarian Neoplasms
/ genetics
Oxaliplatin
Proto-Oncogene Proteins
/ genetics
RNA, Small Interfering
/ pharmacology
RNA-Binding Proteins
/ genetics
Receptor Protein-Tyrosine Kinases
/ genetics
Ribonuclease III
/ metabolism
Up-Regulation
Axl Receptor Tyrosine Kinase
Journal
Molecular cancer therapeutics
ISSN: 1538-8514
Titre abrégé: Mol Cancer Ther
Pays: United States
ID NLM: 101132535
Informations de publication
Date de publication:
01 2019
01 2019
Historique:
received:
27
10
2017
revised:
11
07
2018
accepted:
05
10
2018
pubmed:
12
10
2018
medline:
26
11
2019
entrez:
12
10
2018
Statut:
ppublish
Résumé
For mucinous ovarian cancer (MOC), standard platinum-based therapy is largely ineffective. We sought to identify possible mechanisms of oxaliplatin resistance of MOC and develop strategies to overcome this resistance. A kinome-based siRNA library screen was carried out using human MOC cells to identify novel targets to enhance the efficacy of chemotherapy.
Identifiants
pubmed: 30305341
pii: 1535-7163.MCT-17-1050
doi: 10.1158/1535-7163.MCT-17-1050
pmc: PMC6318044
mid: NIHMS1509631
doi:
Substances chimiques
MIRN515 microRNA, human
0
MicroRNAs
0
PRKRA protein, human
0
Proto-Oncogene Proteins
0
RNA, Small Interfering
0
RNA-Binding Proteins
0
Oxaliplatin
04ZR38536J
Receptor Protein-Tyrosine Kinases
EC 2.7.10.1
DICER1 protein, human
EC 3.1.26.3
Ribonuclease III
EC 3.1.26.3
DEAD-box RNA Helicases
EC 3.6.4.13
Axl Receptor Tyrosine Kinase
0
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
162-172Subventions
Organisme : NCI NIH HHS
ID : T32 CA101642
Pays : United States
Organisme : NCI NIH HHS
ID : P30 CA016672
Pays : United States
Organisme : NCI NIH HHS
ID : U01 CA213759
Pays : United States
Organisme : NCI NIH HHS
ID : P50 CA217685
Pays : United States
Organisme : NCI NIH HHS
ID : R35 CA209904
Pays : United States
Organisme : NCATS NIH HHS
ID : UH3 TR000943
Pays : United States
Informations de copyright
©2018 American Association for Cancer Research.
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