Spermidine: a physiological autophagy inducer acting as an anti-aging vitamin in humans?
Autophagy
cancer
cardiovascular diseases
health span extension
longevity
Journal
Autophagy
ISSN: 1554-8635
Titre abrégé: Autophagy
Pays: United States
ID NLM: 101265188
Informations de publication
Date de publication:
01 2019
01 2019
Historique:
pubmed:
12
10
2018
medline:
27
3
2020
entrez:
12
10
2018
Statut:
ppublish
Résumé
Spermidine is a natural polyamine that stimulates cytoprotective macroautophagy/autophagy. External supplementation of spermidine extends lifespan and health span across species, including in yeast, nematodes, flies and mice. In humans, spermidine levels decline with aging, and a possible connection between reduced endogenous spermidine concentrations and age-related deterioration has been suggested. Recent epidemiological data support this notion, showing that an increased uptake of this polyamine with spermidine-rich food diminishes overall mortality associated with cardiovascular diseases and cancer. Here, we discuss nutritional and other possible routes to counteract the age-mediated decline of spermidine levels.
Identifiants
pubmed: 30306826
doi: 10.1080/15548627.2018.1530929
pmc: PMC6287690
doi:
Substances chimiques
Vitamins
0
Spermidine
U87FK77H25
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
165-168Références
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