miR-31 regulates energy metabolism and is suppressed in T cells from patients with Sjögren's syndrome.
Autoimmunity
Immune regulation
Interferons
Metabolism
Rheumatology
Journal
European journal of immunology
ISSN: 1521-4141
Titre abrégé: Eur J Immunol
Pays: Germany
ID NLM: 1273201
Informations de publication
Date de publication:
02 2019
02 2019
Historique:
received:
14
11
2017
revised:
24
09
2018
accepted:
09
10
2018
pubmed:
12
10
2018
medline:
20
5
2020
entrez:
12
10
2018
Statut:
ppublish
Résumé
Systemic autoimmune diseases are characterized by the overexpression of type I IFN stimulated genes, and accumulating evidence indicate a role for type I IFNs in these diseases. However, the underlying mechanisms for this are still poorly understood. To explore the role of type I IFN regulated miRNAs in systemic autoimmune disease, we characterized cellular expression of miRNAs during both acute and chronic type I IFN responses. We identified a T cell-specific reduction of miR-31-5p levels, both after intramuscular injection of IFNβ and in patients with Sjögren's syndrome (SjS). To interrogate the role of miR-31-51p in T cells we transfected human CD4
Identifiants
pubmed: 30307034
doi: 10.1002/eji.201747416
doi:
Substances chimiques
Interferon-alpha
0
MIRN31 microRNA, human
0
MicroRNAs
0
Interferon-beta
77238-31-4
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
313-322Informations de copyright
© 2018 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.