Understanding molecular mechanisms of disease through spatial proteomics.


Journal

Current opinion in chemical biology
ISSN: 1879-0402
Titre abrégé: Curr Opin Chem Biol
Pays: England
ID NLM: 9811312

Informations de publication

Date de publication:
02 2019
Historique:
received: 11 08 2018
revised: 17 09 2018
accepted: 19 09 2018
pubmed: 12 10 2018
medline: 18 5 2019
entrez: 12 10 2018
Statut: ppublish

Résumé

Mammalian cells are organized into different compartments that separate and facilitate physiological processes by providing specialized local environments and allowing different, otherwise incompatible biological processes to be carried out simultaneously. Proteins are targeted to these subcellular locations where they fulfill specialized, compartment-specific functions. Spatial proteomics aims to localize and quantify proteins within subcellular structures.

Identifiants

pubmed: 30308467
pii: S1367-5931(18)30135-2
doi: 10.1016/j.cbpa.2018.09.016
pmc: PMC6435883
mid: NIHMS1509192
pii:
doi:

Substances chimiques

Proteins 0

Types de publication

Journal Article Research Support, N.I.H., Extramural Review

Langues

eng

Sous-ensembles de citation

IM

Pagination

19-25

Subventions

Organisme : NIGMS NIH HHS
ID : P41 GM103533
Pays : United States
Organisme : NIMH NIH HHS
ID : R01 MH067880
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL131697
Pays : United States
Organisme : NIMH NIH HHS
ID : R01 MH100175
Pays : United States
Organisme : NIDA NIH HHS
ID : U01 DA040709
Pays : United States
Organisme : NIGMS NIH HHS
ID : R01 GM028521
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL079442
Pays : United States
Organisme : NIA NIH HHS
ID : R56 AG057459
Pays : United States
Organisme : NCI NIH HHS
ID : R33 CA212973
Pays : United States
Organisme : NEI NIH HHS
ID : R01 EY011261
Pays : United States
Organisme : NEI NIH HHS
ID : U01 EY027261
Pays : United States

Informations de copyright

Copyright © 2018 Elsevier Ltd. All rights reserved.

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Auteurs

Sandra Pankow (S)

Department of Molecular Medicine, The Scripps Research Institute, La Jolla, CA, 92037, United States.

Salvador Martínez-Bartolomé (S)

Department of Molecular Medicine, The Scripps Research Institute, La Jolla, CA, 92037, United States.

Casimir Bamberger (C)

Department of Molecular Medicine, The Scripps Research Institute, La Jolla, CA, 92037, United States.

John R Yates (JR)

Department of Molecular Medicine, The Scripps Research Institute, La Jolla, CA, 92037, United States. Electronic address: jyates@scripps.edu.

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Classifications MeSH