Development and validation of a method for simultaneous determination of trace levels of five macrocyclic lactones in cheese by HPLC-fluorescence after solid-liquid extraction with low temperature partitioning.
Animals
Anti-Bacterial Agents
/ analysis
Cattle
Cheese
/ analysis
Chromatography, High Pressure Liquid
Cold Temperature
Food Analysis
/ methods
Food Contamination
/ analysis
Lactones
/ analysis
Limit of Detection
Macrocyclic Compounds
/ chemistry
Solid Phase Extraction
Spectrometry, Fluorescence
Time Factors
Acrocyclic lactones
Avermectin
Cheese analysis
HPLC-fluorescence
Milbemycin
Solid-liquid extraction with low temperature partitioning (SLE-LTP)
Veterinary drug residues
Journal
Food chemistry
ISSN: 1873-7072
Titre abrégé: Food Chem
Pays: England
ID NLM: 7702639
Informations de publication
Date de publication:
30 Jan 2019
30 Jan 2019
Historique:
received:
16
03
2018
revised:
18
07
2018
accepted:
07
08
2018
entrez:
13
10
2018
pubmed:
13
10
2018
medline:
12
12
2018
Statut:
ppublish
Résumé
A highly sensitive analytical method was developed and validated, following international guidelines, for the determination of the residues of five macrocyclic lactones (MLs) (abamectin, doramectin, eprinomectin, ivermectin and moxidectin) in cheese. The extracts were concentrated by rotary-evaporation and derivatized; no clean-up was necessary. Despite matrix complexity, no significant matrix-effect was verified, and standards were prepared in solvents. Linear working ranges varied from 0.25 to 5.0 μg L
Identifiants
pubmed: 30309525
pii: S0308-8146(18)31428-6
doi: 10.1016/j.foodchem.2018.08.027
pii:
doi:
Substances chimiques
Anti-Bacterial Agents
0
Lactones
0
Macrocyclic Compounds
0
Types de publication
Journal Article
Validation Study
Langues
eng
Sous-ensembles de citation
IM
Pagination
148-156Informations de copyright
Copyright © 2018 Elsevier Ltd. All rights reserved.