Prevalence and Clinical Features of Celiac Disease in Healthy School-Aged Children.
Age of Onset
Autoantibodies
/ blood
Biopsy
Case-Control Studies
Celiac Disease
/ blood
Child
Cyprus
/ epidemiology
Female
GTP-Binding Proteins
/ immunology
Humans
IgA Deficiency
/ epidemiology
Immunoglobulin A
/ blood
Immunoglobulin G
/ blood
Intestine, Small
/ pathology
Male
Prevalence
Protein Glutamine gamma Glutamyltransferase 2
Serologic Tests
Transglutaminases
/ immunology
Celiac disease
Children
IgA anti-tissue transglutaminase
Prevalence
Journal
Digestive diseases and sciences
ISSN: 1573-2568
Titre abrégé: Dig Dis Sci
Pays: United States
ID NLM: 7902782
Informations de publication
Date de publication:
01 2019
01 2019
Historique:
received:
02
05
2018
accepted:
03
10
2018
pubmed:
13
10
2018
medline:
5
2
2019
entrez:
13
10
2018
Statut:
ppublish
Résumé
The aim of this study was to determine the prevalence of celiac disease (CD) in healthy school-aged children in the northern region of Cyprus and to investigate the existence of potential markers that may accompany CD. This is the first study to measure the prevalence of CD in the northern region of Cyprus. This study included 3792 school-aged children who were between the ages of 6 and 10 years between January 2015 and October 2016. CD was screened using total serum IgA, IgA anti-tissue transglutaminase (tTG), and IgA antiendomysial (EMA) antibodies. Subjects with selective IgA deficiency were further tested for IgG-tTG. Small intestinal biopsies were performed on all subjects with tTG antibody positivity. Risk factors and symptoms related to CD were evaluated using questionnaires in both the CD and control groups. Of the 3792 subjects, 39 were antibody positive (IgA-tTG was positive only in 14 subjects, IgA-tTG plus IgA-EMA in 21 subjects, and IgG-tTG in 4 subjects). IgA deficiency was detected in 11 subjects (0.29%). IgG-tTG was positive in 4 subjects with IgA deficiency (36.3%). Intestinal biopsies were performed on 28 of the 39 seropositive subjects. The biopsy findings of 15 children were consistent with CD (IgA-tTG positive in 3, IgA-tTG and IgA-EMA positive in 10, and IgG-tTG positive in 2). Thus, biopsies confirmed CD in 1:256 children (0.39%). Our study, which is the first study of school-aged children from the northern region of Cyprus, revealed that CD is a prevalent disease in this region.
Sections du résumé
BACKGROUND/AIMS
The aim of this study was to determine the prevalence of celiac disease (CD) in healthy school-aged children in the northern region of Cyprus and to investigate the existence of potential markers that may accompany CD. This is the first study to measure the prevalence of CD in the northern region of Cyprus.
METHODS
This study included 3792 school-aged children who were between the ages of 6 and 10 years between January 2015 and October 2016. CD was screened using total serum IgA, IgA anti-tissue transglutaminase (tTG), and IgA antiendomysial (EMA) antibodies. Subjects with selective IgA deficiency were further tested for IgG-tTG. Small intestinal biopsies were performed on all subjects with tTG antibody positivity. Risk factors and symptoms related to CD were evaluated using questionnaires in both the CD and control groups.
RESULTS
Of the 3792 subjects, 39 were antibody positive (IgA-tTG was positive only in 14 subjects, IgA-tTG plus IgA-EMA in 21 subjects, and IgG-tTG in 4 subjects). IgA deficiency was detected in 11 subjects (0.29%). IgG-tTG was positive in 4 subjects with IgA deficiency (36.3%). Intestinal biopsies were performed on 28 of the 39 seropositive subjects. The biopsy findings of 15 children were consistent with CD (IgA-tTG positive in 3, IgA-tTG and IgA-EMA positive in 10, and IgG-tTG positive in 2). Thus, biopsies confirmed CD in 1:256 children (0.39%).
CONCLUSIONS
Our study, which is the first study of school-aged children from the northern region of Cyprus, revealed that CD is a prevalent disease in this region.
Identifiants
pubmed: 30311156
doi: 10.1007/s10620-018-5320-0
pii: 10.1007/s10620-018-5320-0
doi:
Substances chimiques
Autoantibodies
0
Immunoglobulin A
0
Immunoglobulin G
0
Protein Glutamine gamma Glutamyltransferase 2
EC 2.3.2.13
Transglutaminases
EC 2.3.2.13
GTP-Binding Proteins
EC 3.6.1.-
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
173-181Investigateurs
Adem Karbuz
(A)
Serhat Guler
(S)
Alper Kacar
(A)
Soner Sazak
(S)
Figen Ince
(F)
Mine Ozdil Cirkinoglu
(M)
Bircan Kavaz
(B)
Hulya Madi
(H)
Sevgi Oksuz
(S)
Bekir Yigit Develi
(BY)
Nazife Oner
(N)
Kamuran Aribuka
(K)
Saziye Guçlu
(S)
Remzi Gardiyanoglu
(R)
Nurcin Incirli
(N)
Références
J Pediatr Gastroenterol Nutr. 2000 Nov;31(5):513-9
pubmed: 11144436
Pediatrics. 2013 Mar;131(3):e687-94
pubmed: 23420914
Pediatrics. 2014 Feb;133(2):211-8
pubmed: 24420802
Arch Intern Med. 2003 Feb 10;163(3):286-92
pubmed: 12578508
Aliment Pharmacol Ther. 2012 Mar;35(5):540-51
pubmed: 22239821
Gastroenterology. 1992 Jan;102(1):330-54
pubmed: 1727768
J Pediatr Gastroenterol Nutr. 2016 Mar;62(3):507-13
pubmed: 26815017
Pediatrics. 2009 Dec;124(6):1572-8
pubmed: 19948628
Am J Gastroenterol. 2011 Aug;106(8):1512-7
pubmed: 21691340
J Pediatr Gastroenterol Nutr. 2004 Jul;39(1):80-4
pubmed: 15187786
J Clin Gastroenterol. 2017 May/Jun;51(5):412-416
pubmed: 27306936
BMC Pediatr. 2008 Sep 11;8:35
pubmed: 18786241
Pediatrics. 2010 Mar;125(3):e518-24
pubmed: 20123763
Gastroenterology. 2005 Apr;128(4 Suppl 1):S57-67
pubmed: 15825128
Ann Med. 2010 Dec;42(8):587-95
pubmed: 21070098
J Gastroenterol. 2018 Mar;53(3):377-386
pubmed: 28589338
JAMA Pediatr. 2015 Mar;169(3):e1525
pubmed: 25730696
Acta Paediatr. 2013 Jul;102(7):749-54
pubmed: 23600795
Pediatrics. 2013 Oct;132(4):e924-31
pubmed: 24019416
J Clin Gastroenterol. 2008 Mar;42(3):256-60
pubmed: 18223500
J Clin Gastroenterol. 2005 Sep;39(8):689-91
pubmed: 16082278
World Health Organ Tech Rep Ser. 1995;854:1-452
pubmed: 8594834
Pediatrics. 2015 Apr;135(4):627-34
pubmed: 25733751
J Pediatr Gastroenterol Nutr. 2014 Jul;59 Suppl 1:S7-9
pubmed: 24979197
Gut. 2013 Jan;62(1):43-52
pubmed: 22345659
Nat Rev Immunol. 2013 Apr;13(4):294-302
pubmed: 23493116
Gastroenterology. 2017 Aug;153(2):410-419.e17
pubmed: 28461188
J Pediatr Gastroenterol Nutr. 2005 Jan;40(1):1-19
pubmed: 15625418
Br J Gen Pract. 2007 Aug;57(541):636-42
pubmed: 17688758
J Clin Gastroenterol. 2019 Feb;53(2):e61-e67
pubmed: 29095420
Dig Liver Dis. 2011 Aug;43(8):604-8
pubmed: 21342796
J Pediatr Gastroenterol Nutr. 2012 Jan;54(1):136-60
pubmed: 22197856
Scand J Gastroenterol. 2005 Jan;40(1):15-9
pubmed: 15841709
Eur J Gastroenterol Hepatol. 2007 Nov;19(11):982-7
pubmed: 18049168
BMC Public Health. 2014 Aug 07;14:806
pubmed: 25099430
J Clin Gastroenterol. 2016 Aug;50(7):551-60
pubmed: 26535478
N Engl J Med. 2007 Oct 25;357(17):1731-43
pubmed: 17960014
Clin Chem Lab Med. 2010 May;48(5):685-91
pubmed: 20201743
Nat Med. 2012 Feb 26;18(3):441-5
pubmed: 22366952
J Clin Pathol. 2002 Jul;55(7):488-94
pubmed: 12101191
Am J Gastroenterol. 2008 Sep;103(9):2360-5; quiz 2366
pubmed: 18702652
J Pediatr Gastroenterol Nutr. 1999 Jan;28(1):26-30
pubmed: 9890464