Psychiatric comorbidity in persons with high-functioning autism spectrum disorders: Findings from a tertiary care neuropsychiatric hospital.
Adolescent
Adult
Asperger Syndrome
/ epidemiology
Autism Spectrum Disorder
/ epidemiology
Bipolar Disorder
/ epidemiology
Comorbidity
Female
Hospitals, Psychiatric
/ statistics & numerical data
Humans
India
/ epidemiology
Male
Obsessive-Compulsive Disorder
/ epidemiology
Psychotic Disorders
/ epidemiology
Retrospective Studies
Tertiary Healthcare
/ statistics & numerical data
Young Adult
Asperger’s syndrome
High functioning autism
Obsessive-compulsive disorder
Schizophrenia
Journal
Asian journal of psychiatry
ISSN: 1876-2026
Titre abrégé: Asian J Psychiatr
Pays: Netherlands
ID NLM: 101517820
Informations de publication
Date de publication:
Mar 2019
Mar 2019
Historique:
received:
23
04
2018
revised:
20
07
2018
accepted:
24
09
2018
pubmed:
15
10
2018
medline:
14
8
2019
entrez:
15
10
2018
Statut:
ppublish
Résumé
The literature on co-morbid psychiatric illnesses in adults with high-functioning autism (HFA) spectrum disorder is sparse. To examine the nature of psychiatric comorbidity and treatment response in adults with HFA spectrum disorder. Case records of subjects (age ≥17 years) who presented over a period of 16 years with primary psychiatric symptoms and further detected to have an HFA spectrum disorder, were analyzed. Autism spectrum disorders (ASD) along with near normal to normal verbal communication and general intelligence were considered as HFA spectrum disorders. 33 subjects met the study criteria. Nine subjects (27%) were diagnosed to have an underlying Asperger's syndrome and the rest 24 (73%) had pervasive developmental disorders unspecified (PDD NOS). None of the subjects were diagnosed to be suffering from ASD prior to the visit to our hospital. Mean age at the time of psychiatric consultation was 22.7 (s.d=4.8) years and mean age at the onset of psychiatric comorbidity was 16.48 (s.d=4.4) years. Nearly half of the sample had more than one type of psychiatric illness. Most common lifetime psychiatric diagnosis was obsessive-compulsive disorder (OCD) (n=16, 48.4%). Bipolar disorder (BD) was the second most common type of psychiatric manifestation (n=13, 39.3%) followed by psychotic spectrum disorders (n=9, 27.2%). Overall response to treatment was minimal. Individuals with HFA spectrum disorders suffer from multiple psychiatric comorbidities. OCD is the most common type of psychiatric comorbidity followed by BD and psychotic spectrum disorders. Comorbid psychiatric illnesses in individuals with HFA show poor response to treatment.
Sections du résumé
BACKGROUND
BACKGROUND
The literature on co-morbid psychiatric illnesses in adults with high-functioning autism (HFA) spectrum disorder is sparse.
PURPOSE
OBJECTIVE
To examine the nature of psychiatric comorbidity and treatment response in adults with HFA spectrum disorder.
MATERIALS AND METHODS
METHODS
Case records of subjects (age ≥17 years) who presented over a period of 16 years with primary psychiatric symptoms and further detected to have an HFA spectrum disorder, were analyzed. Autism spectrum disorders (ASD) along with near normal to normal verbal communication and general intelligence were considered as HFA spectrum disorders.
RESULTS
RESULTS
33 subjects met the study criteria. Nine subjects (27%) were diagnosed to have an underlying Asperger's syndrome and the rest 24 (73%) had pervasive developmental disorders unspecified (PDD NOS). None of the subjects were diagnosed to be suffering from ASD prior to the visit to our hospital. Mean age at the time of psychiatric consultation was 22.7 (s.d=4.8) years and mean age at the onset of psychiatric comorbidity was 16.48 (s.d=4.4) years. Nearly half of the sample had more than one type of psychiatric illness. Most common lifetime psychiatric diagnosis was obsessive-compulsive disorder (OCD) (n=16, 48.4%). Bipolar disorder (BD) was the second most common type of psychiatric manifestation (n=13, 39.3%) followed by psychotic spectrum disorders (n=9, 27.2%). Overall response to treatment was minimal.
CONCLUSIONS
CONCLUSIONS
Individuals with HFA spectrum disorders suffer from multiple psychiatric comorbidities. OCD is the most common type of psychiatric comorbidity followed by BD and psychotic spectrum disorders. Comorbid psychiatric illnesses in individuals with HFA show poor response to treatment.
Identifiants
pubmed: 30316630
pii: S1876-2018(18)30328-9
doi: 10.1016/j.ajp.2018.09.008
pii:
doi:
Types de publication
Journal Article
Langues
eng
Pagination
50-53Informations de copyright
Copyright © 2018 Elsevier B.V. All rights reserved.