Role of regulatory T cells in CD47/donor-specific transfusion-induced immune tolerance in skin-heart transplantation mice.
Allografts
/ immunology
Animals
Blood Transfusion
CD47 Antigen
/ genetics
Disease Models, Animal
Female
Graft Rejection
/ immunology
Graft Survival
/ immunology
Heart Transplantation
/ adverse effects
Humans
Immune Tolerance
/ immunology
Lymphocyte Activation
/ immunology
Mice
Mice, Inbred C57BL
Mice, Knockout
Skin Transplantation
/ adverse effects
Spleen
/ cytology
T-Lymphocytes, Regulatory
/ immunology
Treatment Outcome
DST
Treg cells
co-transplantation of skin and heart
immune tolerance
Journal
Transplant infectious disease : an official journal of the Transplantation Society
ISSN: 1399-3062
Titre abrégé: Transpl Infect Dis
Pays: Denmark
ID NLM: 100883688
Informations de publication
Date de publication:
Feb 2019
Feb 2019
Historique:
received:
31
05
2018
revised:
10
08
2018
accepted:
21
08
2018
pubmed:
16
10
2018
medline:
6
4
2019
entrez:
16
10
2018
Statut:
ppublish
Résumé
To explore the role of regulatory T (T C57BL/6 mice received DST of splenocytes from CD47 We observed that mean survival time (MST) of skin or heart graft was significantly longer in C57BL/6 mice which received DST from CD47 Our results indicated that CD47 expression on DST cells plays an important role in the induction of immune tolerance in mice with skin-heart transplantation. Increased percentage of T
Substances chimiques
CD47 Antigen
0
Cd47 protein, mouse
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
e13012Subventions
Organisme : National Natural Science Foundation of China
ID : 81671574
Organisme : National Natural Science Foundation of China
ID : 81501381
Organisme : National Natural Science Foundation of China
ID : 81470975
Informations de copyright
© 2018 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.