17β-Hydroxysteroid dehydrogenases and neurosteroid metabolism in the central nervous system.
AD
Dual enzyme molecular switch
HSD10 deficiency
Neuroexcitability
Neurosteroidogenesis
Non-genomic pathway
Journal
Molecular and cellular endocrinology
ISSN: 1872-8057
Titre abrégé: Mol Cell Endocrinol
Pays: Ireland
ID NLM: 7500844
Informations de publication
Date de publication:
01 06 2019
01 06 2019
Historique:
received:
29
09
2017
revised:
21
08
2018
accepted:
04
10
2018
pubmed:
16
10
2018
medline:
7
1
2020
entrez:
16
10
2018
Statut:
ppublish
Résumé
17β-Hydroxysteroid dehydrogenases are indispensable for downstream enzyme steps of the neurosteroidogenesis. Neurosteroids are synthesized de novo in neurons and glia from cholesterol transported into mitochondria, or by conversion from proneurosteroids, e. g. dehydroepiandrosterone (DHEA) and pregnenolone, through the same metabolic pathway as revealed in the de novo neurosteroidogenesis. Hormonal steroids generated from endocrine glands are transported into brain from the circulation to exert neuronal activity via genomic pathway, whereas neurosteroids produced in brain cells without genomic targets identified could bind to cell surface targets, e.g., GABA
Identifiants
pubmed: 30321584
pii: S0303-7207(18)30283-1
doi: 10.1016/j.mce.2018.10.002
pii:
doi:
Substances chimiques
Neurosteroids
0
17-Hydroxysteroid Dehydrogenases
EC 1.1.-
3 (or 17)-beta-hydroxysteroid dehydrogenase
EC 1.1.1.51
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
92-97Informations de copyright
Copyright © 2018. Published by Elsevier B.V.