(-)‑Oleocanthal inhibits proliferation and migration by modulating Ca
Aldehydes
/ isolation & purification
Calcium
/ metabolism
Cell Line, Tumor
Cell Movement
/ drug effects
Cell Proliferation
/ drug effects
Cell Survival
/ drug effects
Cyclopentane Monoterpenes
Female
Humans
MCF-7 Cells
Olive Oil
/ chemistry
Phenols
/ isolation & purification
TRPC6 Cation Channel
/ metabolism
Triple Negative Breast Neoplasms
/ drug therapy
Calcium entry
Countercurrent chromatography
MCF7
MDA-MB-231 breast cancer cells
Migration
Oleocanthal
Olive oil phenolic
Proliferation
TRPC6
Journal
Biochimica et biophysica acta. Molecular cell research
ISSN: 1879-2596
Titre abrégé: Biochim Biophys Acta Mol Cell Res
Pays: Netherlands
ID NLM: 101731731
Informations de publication
Date de publication:
03 2019
03 2019
Historique:
received:
18
05
2018
revised:
08
10
2018
accepted:
11
10
2018
pubmed:
16
10
2018
medline:
11
9
2019
entrez:
16
10
2018
Statut:
ppublish
Résumé
Triple negative breast cancer is an aggressive type of cancer that does not respond to hormonal therapy and current therapeutic strategies are accompanied by side effects due to cytotoxic actions on normal tissues. Therefore, there is a need for the identification of anti-cancer compounds with negligible effects on non-tumoral cells. Here we show that (-)‑oleocanthal (OLCT), a phenolic compound isolated from olive oil, selectively impairs MDA-MB-231 cell proliferation and viability without affecting the ability of non-tumoral MCF10A cells to proliferate or their viability. Similarly, OLCT selectively impairs the ability of MDA-MB-231 cells to migrate while the ability of MCF10A to migrate was unaffected. The effect of OLCT was not exclusive for triple negative breast cancer cells as we found that OLCT also attenuate cell viability and proliferation of MCF7 cells. Our results indicate that OLCT is unable to induce Ca
Identifiants
pubmed: 30321616
pii: S0167-4889(18)30451-8
doi: 10.1016/j.bbamcr.2018.10.010
pii:
doi:
Substances chimiques
Aldehydes
0
Cyclopentane Monoterpenes
0
Olive Oil
0
Phenols
0
TRPC6 Cation Channel
0
TRPC6 protein, human
0
oleocanthal
AC7QO6038O
Calcium
SY7Q814VUP
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
474-485Informations de copyright
Copyright © 2018 Elsevier B.V. All rights reserved.