Normothermic versus hypothermic cardiopulmonary bypass in low-risk paediatric heart surgery: a randomised controlled trial.
Blood Urea Nitrogen
Body Temperature
/ physiology
Cardiac Surgical Procedures
/ adverse effects
Cardiopulmonary Bypass
/ methods
Child
Creatinine
/ analysis
Female
Heart Defects, Congenital
/ surgery
Humans
Hypothermia, Induced
/ adverse effects
Infant
Lipocalin-2
/ analysis
Male
Postoperative Complications
/ diagnosis
Serum Albumin, Human
/ urine
Treatment Outcome
Congenital Heart Disease
Journal
Heart (British Cardiac Society)
ISSN: 1468-201X
Titre abrégé: Heart
Pays: England
ID NLM: 9602087
Informations de publication
Date de publication:
03 2019
03 2019
Historique:
received:
08
05
2018
revised:
16
07
2018
accepted:
15
08
2018
pubmed:
17
10
2018
medline:
3
5
2019
entrez:
17
10
2018
Statut:
ppublish
Résumé
To compare normothermic (35°C-36°C) versus hypothermic (28°C) cardiopulmonary bypass (CPB) in paediatric patients undergoing open heart surgery to test the hypothesis that normothermic CPB perfusion maintains the functional integrity of major organ systems leading to faster recovery. Two single-centre, randomised controlled trials (known as In total, 200 participants were recruited; 59 to the Normothermic CPB is as safe and effective as hypothermic CPB and can be routinely adopted as a perfusion strategy in low-risk infants and children undergoing open heart surgery. ISRCTN93129502.
Identifiants
pubmed: 30322847
pii: heartjnl-2018-313567
doi: 10.1136/heartjnl-2018-313567
pmc: PMC6580777
doi:
Substances chimiques
Lipocalin-2
0
Creatinine
AYI8EX34EU
Serum Albumin, Human
ZIF514RVZR
Banques de données
ISRCTN
['ISRCTN93129502']
Types de publication
Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
455-464Subventions
Organisme : British Heart Foundation
ID : CH/17/1/32804
Pays : United Kingdom
Organisme : British Heart Foundation
ID : CH/1992027/7163
Pays : United Kingdom
Organisme : Medical Research Council
ID : G0800800
Pays : United Kingdom
Organisme : British Heart Foundation
ID : PG/15/33/31394
Pays : United Kingdom
Informations de copyright
© Author(s) (or their employer(s)) 2019. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.
Déclaration de conflit d'intérêts
Competing interests: None declared.
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