Mechanisms underlying prelimbic prefrontal cortex mGlu

Animals Appetitive Behavior / drug effects Central Nervous System Agents / pharmacology Cerebral Cortex / drug effects Conditioning, Operant / drug effects Learning Disabilities / etiology Male Mice, Inbred C57BL Neuronal Plasticity / drug effects Pyramidal Cells / drug effects Receptor, Metabotropic Glutamate 5 / agonists Receptors, Metabotropic Glutamate / metabolism Restraint, Physical Reversal Learning / drug effects Stress, Psychological / metabolism Tissue Culture Techniques
Prelimbic prefrontal cortex Reversal learning Stress Synaptic plasticity mGlu(3) mGlu(5)

Journal

Neuropharmacology
ISSN: 1873-7064
Titre abrégé: Neuropharmacology
Pays: England
ID NLM: 0236217

Informations de publication

Date de publication:
01 2019
Historique:
received: 23 07 2018
revised: 22 09 2018
accepted: 12 10 2018
pubmed: 17 10 2018
medline: 5 3 2019
entrez: 17 10 2018
Statut: ppublish

Résumé

Stress can precipitate or worsen symptoms of many psychiatric illnesses. Dysregulation of the prefrontal cortex (PFC) glutamate system may underlie these disruptions and restoring PFC glutamate signaling has emerged as a promising avenue for the treatment of stress disorders. Recently, we demonstrated that activation of metabotropic glutamate receptor subtype 3 (mGlu

Identifiants

DOI: 10.1016/j.neuropharm.2018.10.013 PMID: 30326237 PMC: PMC6286225
pubmed: 30326237
pii: S0028-3908(18)30406-4
doi: 10.1016/j.neuropharm.2018.10.013
pmc: PMC6286225
mid: NIHMS1510142
pii:
doi:

Substances chimiques

Central Nervous System Agents 0
Receptor, Metabotropic Glutamate 5 0
Receptors, Metabotropic Glutamate 0
metabotropic glutamate receptor 3 0

Types de publication

Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

19-28

Subventions

Organisme : NIMH NIH HHS
ID : R01 MH062646
Pays : United States
Organisme : NIMH NIH HHS
ID : K01 MH112983
Pays : United States
Organisme : NICHD NIH HHS
ID : U54 HD083211
Pays : United States
Organisme : NIMH NIH HHS
ID : T32 MH093366
Pays : United States
Organisme : NINDS NIH HHS
ID : R37 NS031373
Pays : United States

Informations de copyright

Copyright © 2018. Published by Elsevier Ltd.

Auteurs

Max E Joffe (ME)

Department of Pharmacology, Vanderbilt University, Nashville, TN, 37232, USA; Vanderbilt Center for Neuroscience Drug Discovery, Nashville, TN, 37232, USA; Vanderbilt Center for Addiction Research, Nashville, TN, 37232, USA. Electronic address: max.joffe@vanderbilt.edu.

Chiaki I Santiago (CI)

Vanderbilt Center for Neuroscience Drug Discovery, Nashville, TN, 37232, USA.

Branden J Stansley (BJ)

Department of Pharmacology, Vanderbilt University, Nashville, TN, 37232, USA; Vanderbilt Center for Neuroscience Drug Discovery, Nashville, TN, 37232, USA.

James Maksymetz (J)

Department of Pharmacology, Vanderbilt University, Nashville, TN, 37232, USA; Vanderbilt Center for Neuroscience Drug Discovery, Nashville, TN, 37232, USA.

Rocco G Gogliotti (RG)

Department of Pharmacology, Vanderbilt University, Nashville, TN, 37232, USA; Vanderbilt Center for Neuroscience Drug Discovery, Nashville, TN, 37232, USA.

Julie L Engers (JL)

Vanderbilt Center for Neuroscience Drug Discovery, Nashville, TN, 37232, USA.

Ferdinando Nicoletti (F)

Department of Physiology and Pharmacology, University Sapienza of Roma, 00185, Roma, Italy; IRCCS Neuromed, Pozzilli, Italy.

Craig W Lindsley (CW)

Department of Pharmacology, Vanderbilt University, Nashville, TN, 37232, USA; Vanderbilt Center for Neuroscience Drug Discovery, Nashville, TN, 37232, USA; Vanderbilt Center for Addiction Research, Nashville, TN, 37232, USA; Department of Chemistry, Vanderbilt University, Nashville, TN, 37232, USA.

P Jeffrey Conn (PJ)

Department of Pharmacology, Vanderbilt University, Nashville, TN, 37232, USA; Vanderbilt Center for Neuroscience Drug Discovery, Nashville, TN, 37232, USA; Vanderbilt Center for Addiction Research, Nashville, TN, 37232, USA. Electronic address: jeff.conn@vanderbilt.edu.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Mechanisms underlying prelimbic prefrontal cortex mGlu
questionsmedicales.fr › Comportement et mécanismes comportementaux › Comportement › Comportement animal › Comportement appétitif › Mechanisms underlying prelimbic prefrontal cortex mGlu
questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Utilisations thérapeutiques › Agents du système nerveux central › Mechanisms underlying prelimbic prefrontal cortex mGlu
questionsmedicales.fr › Système nerveux › Système nerveux central › Encéphale › Prosencéphale › Télencéphale › Cerveau › Cortex cérébral › Mechanisms underlying prelimbic prefrontal cortex mGlu
questionsmedicales.fr › Phénomènes psychologiques › Processus mentaux › Conditionnement (psychologie) › Conditionnement opérant › Mechanisms underlying prelimbic prefrontal cortex mGlu
questionsmedicales.fr › Troubles mentaux › Troubles du développement neurologique › Incapacités d'apprentissage › Mechanisms underlying prelimbic prefrontal cortex mGlu
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Lignées consanguines de souris › Souris de lignée C57BL › Mechanisms underlying prelimbic prefrontal cortex mGlu
questionsmedicales.fr › Phénomènes physiologiques de l'appareil locomoteur et du système nerveux › Phénomènes physiologiques du système nerveux › Plasticité neuronale › Mechanisms underlying prelimbic prefrontal cortex mGlu
questionsmedicales.fr › Cellules › Neurones › Cellules pyramidales › Mechanisms underlying prelimbic prefrontal cortex mGlu
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Récepteurs de surface cellulaire › Récepteurs aux neuromédiateurs › Récepteurs aux acides aminés › Récepteurs au glutamate › Récepteurs métabotropes au glutamate › Récepteur-5 métabotropique du glutamate › Mechanisms underlying prelimbic prefrontal cortex mGlu
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Récepteurs de surface cellulaire › Récepteurs aux neuromédiateurs › Récepteurs aux acides aminés › Récepteurs au glutamate › Récepteurs métabotropes au glutamate › Mechanisms underlying prelimbic prefrontal cortex mGlu
questionsmedicales.fr › Techniques d'investigation › Immobilisation › Contention physique › Mechanisms underlying prelimbic prefrontal cortex mGlu
questionsmedicales.fr › Phénomènes psychologiques › Processus mentaux › Apprentissage inversé › Mechanisms underlying prelimbic prefrontal cortex mGlu
questionsmedicales.fr › Phénomènes psychologiques › Stress psychologique › Mechanisms underlying prelimbic prefrontal cortex mGlu
questionsmedicales.fr › Techniques d'investigation › Techniques in vitro › Techniques de culture › Techniques de culture de tissus › Mechanisms underlying prelimbic prefrontal cortex mGlu