The Relationship between Mismatch Negativity and the COMTVal108/158Met Genotype in Schizophrenia.
COMTVal108/158Met
Catechol-o-methyltransferase
Event-related potential
Gene
Mismatch negativity
Schizophrenia
Journal
Neuropsychobiology
ISSN: 1423-0224
Titre abrégé: Neuropsychobiology
Pays: Switzerland
ID NLM: 7512895
Informations de publication
Date de publication:
2019
2019
Historique:
received:
30
05
2018
accepted:
13
09
2018
pubmed:
17
10
2018
medline:
16
4
2019
entrez:
17
10
2018
Statut:
ppublish
Résumé
Mismatch negativity (MMN) is a component of auditory event-related potentials that reflects automatic change detection in the brain, showing qualities of endophenotypes in schizophrenia. MMN deficiency is one of the robust findings in patients, and it reflects both cognitive and functional decline. Catechol-o-methyltransferase (COMT) is a key enzyme involved in regulating dopamine transmission within the prefrontal cortex. A preliminary study suggested that the COMTVal108/158Met genotype (rs4680) is related to cognitive function in schizophrenia. Both the COMTVal108/158Met genotype and MMN are related to cognitive function, but no studies have reported on the relationship between MMN and the COMTVal108/158Met genotype in schizophrenia. This study therefore examined the relationship between COMTVal108/158Met genotype and MMN. The duration of MMN was measured, and the COMTVal108/158Met polymorphism was detected by polymerase chain reaction-restriction fragment length polymorphism in 49 Japanese schizophrenia patients (Val/Val, n = 21; Met carriers, n = 28). Amplitude and latency of MMN were compared between Val/Val and Met carriers.
Identifiants
pubmed: 30326466
pii: 000493738
doi: 10.1159/000493738
doi:
Substances chimiques
COMT protein, human
EC 2.1.1.6
Catechol O-Methyltransferase
EC 2.1.1.6
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
192-196Informations de copyright
© 2018 S. Karger AG, Basel.