The burden of cutaneous adnexal carcinomas and the risk of associated squamous cell carcinoma: a population-based study.
Adult
Age Distribution
Age Factors
Aged
Aged, 80 and over
Carcinoma, Skin Appendage
/ epidemiology
Carcinoma, Squamous Cell
/ epidemiology
Cost of Illness
Female
Humans
Incidence
Italy
/ epidemiology
Male
Middle Aged
Registries
/ statistics & numerical data
Risk Factors
Sex Distribution
Sex Factors
Skin Neoplasms
/ epidemiology
Survival Rate
Journal
The British journal of dermatology
ISSN: 1365-2133
Titre abrégé: Br J Dermatol
Pays: England
ID NLM: 0004041
Informations de publication
Date de publication:
03 2019
03 2019
Historique:
accepted:
10
10
2018
pubmed:
18
10
2018
medline:
25
2
2020
entrez:
18
10
2018
Statut:
ppublish
Résumé
Recent studies have shown an increasing incidence of cutaneous adnexal carcinomas (CACs). The aim of our study was to evaluate incidence and survival for cases of CACs and investigate their association with other skin neoplasms. We conducted a population-based study. Data on incident cases of CACs were obtained from the Tuscany Cancer Registry between 1985 and 2010. In order to determine whether the occurrence of squamous cell carcinoma (SCC) among patients with CAC is higher or lower than expected in the general population, the standardized incidence ratio (SIR) was calculated. A total of 242 patients with CAC were observed; the age-standardized incidence rate was 3·8 cases per million person-years. From 1997 to 2010 crude incidence rates increased by 159%. Age-specific incidence was higher in men over 80 years old than in women of the same age and younger individuals. Carcinomas of sweat gland origin prevailed; the most common histotype was porocarcinoma and the most frequently affected site was the head/neck. Overall, 88% of CACs were diagnosed at a localized stage. The 5-year overall survival and disease-specific survival rates were 59% [95% confidence interval (CI) 53-65] and 94% (95% CI 91-98), respectively. In the observation cohort, the number of SCCs was significantly higher than expected as the SIR was calculated to be 33·7 (P < 0·001). Increasing incidence warrants awareness and early diagnosis of CACs. Increased SCC incidence among patients with these tumours highlights the relevance of careful skin examination and follow-up.
Sections du résumé
BACKGROUND
Recent studies have shown an increasing incidence of cutaneous adnexal carcinomas (CACs).
OBJECTIVES
The aim of our study was to evaluate incidence and survival for cases of CACs and investigate their association with other skin neoplasms.
METHODS
We conducted a population-based study. Data on incident cases of CACs were obtained from the Tuscany Cancer Registry between 1985 and 2010. In order to determine whether the occurrence of squamous cell carcinoma (SCC) among patients with CAC is higher or lower than expected in the general population, the standardized incidence ratio (SIR) was calculated.
RESULTS
A total of 242 patients with CAC were observed; the age-standardized incidence rate was 3·8 cases per million person-years. From 1997 to 2010 crude incidence rates increased by 159%. Age-specific incidence was higher in men over 80 years old than in women of the same age and younger individuals. Carcinomas of sweat gland origin prevailed; the most common histotype was porocarcinoma and the most frequently affected site was the head/neck. Overall, 88% of CACs were diagnosed at a localized stage. The 5-year overall survival and disease-specific survival rates were 59% [95% confidence interval (CI) 53-65] and 94% (95% CI 91-98), respectively. In the observation cohort, the number of SCCs was significantly higher than expected as the SIR was calculated to be 33·7 (P < 0·001).
CONCLUSIONS
Increasing incidence warrants awareness and early diagnosis of CACs. Increased SCC incidence among patients with these tumours highlights the relevance of careful skin examination and follow-up.
Types de publication
Journal Article
Observational Study
Langues
eng
Sous-ensembles de citation
IM
Pagination
565-573Commentaires et corrections
Type : CommentIn
Informations de copyright
© 2018 British Association of Dermatologists.