Haemodynamic mechanisms and long-term prognostic impact of pulmonary hypertension in patients with severe aortic stenosis undergoing valve replacement.
Aged
Aortic Valve Stenosis
/ complications
Cardiac Catheterization
Female
Follow-Up Studies
Heart Valve Prosthesis Implantation
Hemodynamics
/ physiology
Humans
Hypertension, Pulmonary
/ epidemiology
Male
Prevalence
Prognosis
Retrospective Studies
Severity of Illness Index
Switzerland
/ epidemiology
Time Factors
Aortic stenosis
Post-capillary
Pre-capillary
Pulmonary capacitance
Pulmonary hypertension
Wedge pressure
Journal
European journal of heart failure
ISSN: 1879-0844
Titre abrégé: Eur J Heart Fail
Pays: England
ID NLM: 100887595
Informations de publication
Date de publication:
02 2019
02 2019
Historique:
received:
30
05
2018
revised:
26
07
2018
accepted:
27
08
2018
pubmed:
18
10
2018
medline:
22
5
2019
entrez:
18
10
2018
Statut:
ppublish
Résumé
We aimed to investigate the prevalence, detailed invasive haemodynamics, and prognostic impact of pulmonary hypertension (PH) in severe aortic stenosis (AS). We studied 503 patients (mean age 74 ± 10 years) with severe AS (indexed aortic valve area 0.4 ± 0.1 cm In patients with severe AS, PH is common but underlying mechanisms differ. Patients with CpcPH have higher mPAWP, lower pulmonary arterial capacitance, and worse survival than all other groups. Left atrial dysfunction and mitral regurgitation seem to be drivers of high mPAWP in CpcPH.
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
172-181Informations de copyright
© 2018 The Authors. European Journal of Heart Failure © 2018 European Society of Cardiology.