Broad Recognition of Circulating HIV-1 by HIV-1-Specific Cytotoxic T-Lymphocytes with Strong Ability to Suppress HIV-1 Replication.
CTL
HIV-1
HLA
cure
epitope
vaccines
Journal
Journal of virology
ISSN: 1098-5514
Titre abrégé: J Virol
Pays: United States
ID NLM: 0113724
Informations de publication
Date de publication:
01 01 2019
01 01 2019
Historique:
received:
27
08
2018
accepted:
10
10
2018
pubmed:
20
10
2018
medline:
1
10
2019
entrez:
19
10
2018
Statut:
epublish
Résumé
HIV-1-specific cytotoxic T-lymphocytes (CTLs) with strong abilities to suppress HIV-1 replication and recognize most circulating HIV-1 strains are candidates for effector T cells for cure treatment and prophylactic AIDS vaccine. Previous studies demonstrated that the existence of CTLs specific for 11 epitopes was significantly associated with good clinical outcomes in Japan, although CTLs specific for one of these epitopes select for escape mutations. However, it remains unknown whether the CTLs specific for the remaining 10 epitopes suppress HIV-1 replication
Identifiants
pubmed: 30333175
pii: JVI.01480-18
doi: 10.1128/JVI.01480-18
pmc: PMC6288335
pii:
doi:
Substances chimiques
AIDS Vaccines
0
Epitopes, T-Lymphocyte
0
HLA-A Antigens
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Informations de copyright
Copyright © 2018 American Society for Microbiology.
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