Programmed longevity, youthspan, and juventology.
Adult
Aged
Aged, 80 and over
Animals
Caloric Restriction
Cyclic AMP-Dependent Protein Kinases
/ antagonists & inhibitors
Diet, Protein-Restricted
Fasting
/ physiology
Free Radicals
/ adverse effects
Growth Hormone
/ antagonists & inhibitors
Humans
Insulin-Like Growth Factor I
/ antagonists & inhibitors
Life Expectancy
Longevity
/ genetics
Mice
Middle Aged
Nutrients
/ physiology
Rejuvenation
/ physiology
Ribosomal Protein S6 Kinases
/ antagonists & inhibitors
Saccharomyces cerevisiae
/ metabolism
Sirolimus
/ pharmacology
TOR Serine-Threonine Kinases
/ antagonists & inhibitors
Young Adult
Juventology
Longevity
aging
gerontology
healthspan
youthspan
Journal
Aging cell
ISSN: 1474-9726
Titre abrégé: Aging Cell
Pays: England
ID NLM: 101130839
Informations de publication
Date de publication:
02 2019
02 2019
Historique:
received:
17
05
2018
revised:
24
07
2018
accepted:
17
08
2018
pubmed:
20
10
2018
medline:
27
2
2020
entrez:
19
10
2018
Statut:
ppublish
Résumé
The identification of conserved genes and pathways that regulate lifespan but also healthspan has resulted in an improved understanding of the link between nutrients, signal transduction proteins, and aging but has also provided evidence for the existence of multiple "longevity programs," which are selected based on the availability of nutrients. Periodic fasting and other dietary restrictions can promote entry into a long-lasting longevity program characterized by cellular protection and optimal function but can also activate regenerative processes that lead to rejuvenation, which are independent of the aging rate preceding the restricted period. Thus, a "juventology"-based strategy can complement the traditional gerontology approach by focusing not on aging but on the longevity program affecting the life history period in which mortality is very low and organisms remain youthful, healthy, and fully functional.
Identifiants
pubmed: 30334314
doi: 10.1111/acel.12843
pmc: PMC6351819
doi:
Substances chimiques
Free Radicals
0
Insulin-Like Growth Factor I
67763-96-6
Growth Hormone
9002-72-6
Ribosomal Protein S6 Kinases
EC 2.7.11.1
TOR Serine-Threonine Kinases
EC 2.7.11.1
Cyclic AMP-Dependent Protein Kinases
EC 2.7.11.11
Sirolimus
W36ZG6FT64
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
e12843Subventions
Organisme : NIA/NIH
ID : P01AG055369
Pays : International
Organisme : NIA/NIH
ID : R01AG020642
Pays : International
Organisme : Associazione Italiana per la Ricerca sul Cancro
ID : 17605
Pays : International
Organisme : Associazione Italiana per la Ricerca sul Cancro
ID : AG034906
Pays : International
Informations de copyright
© 2018 The Authors. Aging Cell published by the Anatomical Society and John Wiley & Sons Ltd.
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