Macrophages promote epithelial proliferation following infectious and non-infectious lung injury through a Trefoil factor 2-dependent mechanism.
Animals
Bleomycin
CD11c Antigen
/ metabolism
Cell Communication
Cell Proliferation
Cells, Cultured
Humans
Lung
/ immunology
Lung Injury
/ chemically induced
Macrophages
/ physiology
Mice
Mice, Inbred C57BL
Mice, Knockout
Nippostrongylus
/ immunology
Respiratory Mucosa
/ physiology
Strongylida Infections
/ immunology
Trefoil Factor-2
/ genetics
Wound Healing
Journal
Mucosal immunology
ISSN: 1935-3456
Titre abrégé: Mucosal Immunol
Pays: United States
ID NLM: 101299742
Informations de publication
Date de publication:
01 2019
01 2019
Historique:
received:
22
08
2017
accepted:
17
09
2018
revised:
16
09
2018
pubmed:
20
10
2018
medline:
15
5
2019
entrez:
20
10
2018
Statut:
ppublish
Résumé
Coordinated efforts between macrophages and epithelia are considered essential for wound healing, but the macrophage-derived molecules responsible for repair are poorly defined. This work demonstrates that lung macrophages rely upon Trefoil factor 2 to promote epithelial proliferation following damage caused by sterile wounding, Nippostrongylus brasiliensis or Bleomycin sulfate. Unexpectedly, the presence of T, B, or ILC populations was not essential for macrophage-driven repair. Instead, conditional deletion of TFF2 in myeloid-restricted CD11c
Identifiants
pubmed: 30337651
doi: 10.1038/s41385-018-0096-2
pii: S1933-0219(22)00355-5
pmc: PMC6301101
mid: NIHMS1507830
doi:
Substances chimiques
CD11c Antigen
0
Trefoil Factor-2
0
Bleomycin
11056-06-7
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
64-76Subventions
Organisme : NHLBI NIH HHS
ID : R01 HL119436
Pays : United States
Organisme : NIAID NIH HHS
ID : T32 AI007334
Pays : United States
Organisme : NHLBI NIH HHS
ID : T32 HL007586
Pays : United States
Organisme : NIAID NIH HHS
ID : R01 AI095289
Pays : United States
Organisme : NIGMS NIH HHS
ID : R01 GM083204
Pays : United States
Organisme : NIEHS NIH HHS
ID : P30 ES013508
Pays : United States
Organisme : BLRD VA
ID : I01 BX001176
Pays : United States
Organisme : NIAID NIH HHS
ID : U01 AI125940
Pays : United States
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