Niacinamide and 12-hydroxystearic acid prevented benzo(a)pyrene and squalene peroxides induced hyperpigmentation in skin equivalent.
epidermis
melanin
pollution
sebum
stress
Journal
Experimental dermatology
ISSN: 1600-0625
Titre abrégé: Exp Dermatol
Pays: Denmark
ID NLM: 9301549
Informations de publication
Date de publication:
06 2019
06 2019
Historique:
received:
01
05
2018
accepted:
05
10
2018
pubmed:
20
10
2018
medline:
14
7
2020
entrez:
20
10
2018
Statut:
ppublish
Résumé
Skin surface is constantly exposed to environmental and secreted stressors such as UV, air pollution and peroxidized sebum. The current study aims to use reconstructed human skin equivalents to demonstrate topical stressor-induced hyperpigmentation and evaluate bioactives' potential protective effect. Given that polycyclic aromatic hydrocarbons are representative airborne particle-bound organic compounds with known relevance to pigmentation pathways, benzo(a)pyrene was selected as surrogate environmental toxin. On the other hand, squalene monohydroperoxides are well-characterized sebum peroxidation product under UV and pollutant exposure, thus are used as another representative skin stressor. With 3-day continuous exposure, 30 pmol/cm
Substances chimiques
12-hydroxy stearic acid
0
2,3-oxidosqualene
0
Melanins
0
Stearic Acids
0
Vitamin B Complex
12001-76-2
Niacinamide
25X51I8RD4
Benzo(a)pyrene
3417WMA06D
Squalene
7QWM220FJH
Monophenol Monooxygenase
EC 1.14.18.1
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
742-746Informations de copyright
© 2018 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.