Understanding the functions of kisspeptin and kisspeptin receptor (Kiss1R) from clinical case studies.
Central precocious puberty
Idiopathic hypogonadotropic hypogonadism
Kisspeptin
Receptor signaling
Reproductive system
Journal
Peptides
ISSN: 1873-5169
Titre abrégé: Peptides
Pays: United States
ID NLM: 8008690
Informations de publication
Date de publication:
10 2019
10 2019
Historique:
received:
29
05
2018
revised:
21
09
2018
accepted:
21
09
2018
pubmed:
20
10
2018
medline:
6
6
2020
entrez:
20
10
2018
Statut:
ppublish
Résumé
It is widely acknowledged that kisspeptin and its receptor Kiss1R play central regulatory roles in the hypothalamus-pituitary-gonad (HPG) axis and reproduction. Mutations of KISS1 and KISS1R lead to disorders associated with pubertal development, such as central precocious puberty (CPP) and idiopathic hypogonadotropic hypogonadism (IHH). This review focuses on KISS1 and KISS1R mutations found in CPP and IHH and its purposes are twofold: Firstly, based on the mutations found in KISS1 and KISS1R, this review provides insights into the precise mechanism of kisspeptin and the kisspeptin/Kiss1R pathway in the reproductive axis and in puberty. Secondly, G protein-coupled receptors (GPCRs) are known to share highly conserved structural motifs; therefore, knowledge of mutations found at different structural domains of Kiss1R in the diseased state, and how they affect Kiss1R function can be used to decipher GPCR domain function.
Identifiants
pubmed: 30339828
pii: S0196-9781(18)30176-1
doi: 10.1016/j.peptides.2018.09.007
pii:
doi:
Substances chimiques
KISS1 protein, human
0
KISS1R protein, human
0
Kisspeptins
0
Receptors, Kisspeptin-1
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
170019Informations de copyright
Copyright © 2018 Elsevier Inc. All rights reserved.