Polylactic acid sealed polyelectrolyte complex microcontainers for controlled encapsulation and NIR-Laser based release of cargo.
Alginic Acid
/ chemistry
Chitosan
/ chemistry
Delayed-Action Preparations
/ radiation effects
Drug Compounding
/ methods
Drug Liberation
Hydrophobic and Hydrophilic Interactions
Kinetics
Lasers
Light
Particle Size
Polyamines
/ chemistry
Polyelectrolytes
/ chemistry
Polyesters
/ chemistry
Polyethylenes
/ chemistry
Polystyrenes
/ chemistry
Quaternary Ammonium Compounds
/ chemistry
Rhodamines
/ chemistry
Temperature
Controlled release
NIR-Laser
Polyelectrolyte complex
Polylactic acid
Small hydrophilic molecules
Journal
Colloids and surfaces. B, Biointerfaces
ISSN: 1873-4367
Titre abrégé: Colloids Surf B Biointerfaces
Pays: Netherlands
ID NLM: 9315133
Informations de publication
Date de publication:
01 Jan 2019
01 Jan 2019
Historique:
received:
15
07
2018
revised:
03
10
2018
accepted:
05
10
2018
pubmed:
20
10
2018
medline:
22
3
2019
entrez:
20
10
2018
Statut:
ppublish
Résumé
Surface mediated drug delivery is important for a large variety of applications, especially in medicine to control cell growth, prevent blood platelet activation on implants or for self-disinfecting devices (e.g. catheters). In industrial applications, controlled release of substances from surfaces is needed in a broad range of applications from anti-corrosion systems to anti-biofouling. Polyelectrolyte multilayers (PEM) based microcontainers (MCs) require several days production time, while MCs composed out of polylactic acid (PLA) are entirely hydrophobic, offering no functionality. We hereby present an approach to fabricate PLA coated synthetic as well as biopolymer based biodegradable polyelectrolyte complex MCs able to encapsulate small hydrophilic cargo within less than one hour. The chambers facilitate laser controlled release of cargo within submerged conditions.
Identifiants
pubmed: 30340180
pii: S0927-7765(18)30709-4
doi: 10.1016/j.colsurfb.2018.10.026
pii:
doi:
Substances chimiques
Delayed-Action Preparations
0
Polyamines
0
Polyelectrolytes
0
Polyesters
0
Polyethylenes
0
Polystyrenes
0
Quaternary Ammonium Compounds
0
Rhodamines
0
poly-N,N-dimethyl-N,N-diallylammonium chloride
26062-79-3
polyallylamine
30551-89-4
poly(lactide)
459TN2L5F5
polystyrene sulfonic acid
70KO0R01RY
Alginic Acid
8C3Z4148WZ
Chitosan
9012-76-4
rhodamine B
K7G5SCF8IL
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
521-528Informations de copyright
Copyright © 2018 Elsevier B.V. All rights reserved.