Multisite study of the relationships between antemortem [
Alzheimer's disease neuropathologic changes
CERAD
Centiloid
Harmonization
Neuropathology
Pittsburgh compound-B
Positron emission tomography
Thal
Threshold
β-amyloid
Journal
Alzheimer's & dementia : the journal of the Alzheimer's Association
ISSN: 1552-5279
Titre abrégé: Alzheimers Dement
Pays: United States
ID NLM: 101231978
Informations de publication
Date de publication:
02 2019
02 2019
Historique:
received:
04
04
2018
revised:
08
07
2018
accepted:
03
09
2018
pubmed:
23
10
2018
medline:
11
4
2020
entrez:
23
10
2018
Statut:
ppublish
Résumé
We sought to establish the relationships between standard postmortem measures of AD neuropathology and antemortem [ Four centers contributed 179 participants encompassing a broad range of clinical diagnoses, PET data, and autopsy findings. CL values increased with each CERAD neuritic plaque score increment (median -3 CL for no plaques and 92 CL for frequent plaques) and nonlinearly with Thal Aβ phases (increases were detected starting at phase 2) with overlap between scores/phases. PET-pathology associations were comparable across sites and unchanged when restricting the analyses to the 56 patients who died within 2 years of PET. A threshold of 12.2 CL detected CERAD moderate-to-frequent neuritic plaques (area under the curve = 0.910, sensitivity = 89.2%, specificity = 86.4%), whereas 24.4 CL identified intermediate-to-high AD neuropathological changes (area under the curve = 0.894, sensitivity = 84.1%, specificity = 87.9%). Our study demonstrated the robustness of a multisite Centiloid [
Identifiants
pubmed: 30347188
pii: S1552-5260(18)33523-4
doi: 10.1016/j.jalz.2018.09.001
pmc: PMC6368897
mid: NIHMS1507069
pii:
doi:
Substances chimiques
2-(4'-(methylamino)phenyl)-6-hydroxybenzothiazole
0
Aniline Compounds
0
Thiazoles
0
Types de publication
Journal Article
Multicenter Study
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
205-216Subventions
Organisme : NINDS NIH HHS
ID : R01 NS017950
Pays : United States
Organisme : NIA NIH HHS
ID : R01 AG054076
Pays : United States
Organisme : NIA NIH HHS
ID : P50 AG016574
Pays : United States
Organisme : NIA NIH HHS
ID : K24 AG053435
Pays : United States
Organisme : NIA NIH HHS
ID : R01 AG027859
Pays : United States
Organisme : NIA NIH HHS
ID : R01 AG027984
Pays : United States
Organisme : NIA NIH HHS
ID : P01 AG019724
Pays : United States
Organisme : NIA NIH HHS
ID : R01 AG021028
Pays : United States
Organisme : NIA NIH HHS
ID : R01 AG031563
Pays : United States
Organisme : NIA NIH HHS
ID : P30 AG010129
Pays : United States
Organisme : NIA NIH HHS
ID : R01 AG045611
Pays : United States
Organisme : NIA NIH HHS
ID : P01 AG025204
Pays : United States
Organisme : NIA NIH HHS
ID : U01 AG006786
Pays : United States
Organisme : NIA NIH HHS
ID : R01 AG034570
Pays : United States
Organisme : NIA NIH HHS
ID : R01 AG041851
Pays : United States
Organisme : NIA NIH HHS
ID : P50 AG023501
Pays : United States
Organisme : NIA NIH HHS
ID : P50 AG005142
Pays : United States
Organisme : NIA NIH HHS
ID : K24 AG045333
Pays : United States
Organisme : NIA NIH HHS
ID : R01 AG056366
Pays : United States
Organisme : NIA NIH HHS
ID : R01 AG038791
Pays : United States
Organisme : NIA NIH HHS
ID : R01 AG054449
Pays : United States
Organisme : NIA NIH HHS
ID : R01 AG058676
Pays : United States
Organisme : NIA NIH HHS
ID : R01 AG011378
Pays : United States
Organisme : NIA NIH HHS
ID : P30 AG049638
Pays : United States
Organisme : NIA NIH HHS
ID : P01 AG012435
Pays : United States
Organisme : NIA NIH HHS
ID : R01 AG032306
Pays : United States
Organisme : NIA NIH HHS
ID : P50 AG005133
Pays : United States
Organisme : NIA NIH HHS
ID : K23 AG031861
Pays : United States
Organisme : NIA NIH HHS
ID : RF1 AG025516
Pays : United States
Organisme : NINDS NIH HHS
ID : R01 NS097495
Pays : United States
Informations de copyright
Copyright © 2018 the Alzheimer's Association. Published by Elsevier Inc. All rights reserved.
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