Pathology and Pathogenesis of Chagas Heart Disease.
Chagas
cardiomyopathy
heart
myocarditis
pathogenesis
trypanosome
Journal
Annual review of pathology
ISSN: 1553-4014
Titre abrégé: Annu Rev Pathol
Pays: United States
ID NLM: 101275111
Informations de publication
Date de publication:
24 01 2019
24 01 2019
Historique:
pubmed:
26
10
2018
medline:
21
4
2020
entrez:
26
10
2018
Statut:
ppublish
Résumé
Chagas heart disease is an inflammatory cardiomyopathy that develops in approximately one-third of people infected with the protozoan parasite Trypanosoma cruzi. One way T. cruzi is transmitted to people is through contact with infected kissing bugs, which are found in much of the Western Hemisphere, including in vast areas of the United States. The epidemiology of T. cruzi and Chagas heart disease and the varied mechanisms leading to myocyte destruction, mononuclear cell infiltration, fibrosis, and edema in the heart have been extensively studied by hundreds of scientists for more than 100 years. Despite this wealth of knowledge, it is still impossible to predict what will happen in an individual infected with T. cruzi because of the tremendous variability in clonal parasite virulence and human susceptibility to infection and the lack of definitive molecular predictors of outcome from either side of the host-parasite equation. Further, while several distinct mechanisms of pathogenesis have been studied in isolation, it is certain that multiple coincident mechanisms combine to determine the ultimate outcome. For these reasons, Chagas disease is best considered a collection of related but distinct illnesses. This review highlights the pathology and pathogenesis of the most common adverse sequela of T. cruzi infection-Chagas heart disease-and concludes with a discussion of key unanswered questions and a view to the future.
Identifiants
pubmed: 30355152
doi: 10.1146/annurev-pathol-020117-043711
pmc: PMC7373119
mid: NIHMS1609251
doi:
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
421-447Subventions
Organisme : NIAID NIH HHS
ID : R01 AI054578
Pays : United States
Organisme : NIAID NIH HHS
ID : R01 AI136031
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL075822
Pays : United States
Références
Mediators Inflamm. 2014;2014:243786
pubmed: 25104879
Clin Cardiol. 1987 Nov;10(11):665-70
pubmed: 3677499
Mem Inst Oswaldo Cruz. 2006 Aug;101(5):463-91
pubmed: 17072450
Free Radic Biol Med. 2006 Jul 15;41(2):270-6
pubmed: 16814107
Microbes Infect. 2010 Aug;12(8-9):587-97
pubmed: 20381637
Autoimmunity. 2006 Feb;39(1):41-54
pubmed: 16455581
Immunology. 2011 Jan;132(1):123-33
pubmed: 20875075
Curr Mol Med. 2008 Sep;8(6):510-8
pubmed: 18781958
Clinics (Sao Paulo). 2009;64(12):1219-24
pubmed: 20037711
J Immunol Res. 2016;2016:4396368
pubmed: 27795961
Expert Rev Anti Infect Ther. 2011 May;9(5):609-20
pubmed: 21609270
PLoS One. 2011 Jan 21;6(1):e14571
pubmed: 21283741
Immunol Rev. 2004 Oct;201:304-17
pubmed: 15361249
Microbes Infect. 2010 Jul;12(7):511-7
pubmed: 20348008
Parasitology. 2014 Nov;141(13):1769-78
pubmed: 25093253
Am J Trop Med Hyg. 2016 May 4;94(5):1028-33
pubmed: 26976879
Scand J Immunol. 2000 May;51(5):511-9
pubmed: 10792844
Nat Med. 2000 Aug;6(8):890-7
pubmed: 10932226
Transfusion. 2012 Sep;52(9):1922-30
pubmed: 22404755
Mem Inst Oswaldo Cruz. 1999;94 Suppl 1:71-80
pubmed: 10677693
Am J Pathol. 2015 Jun;185(6):1537-47
pubmed: 25857229
PLoS Pathog. 2014 Dec 04;10(12):e1004516
pubmed: 25474113
J Immunol. 2009 May 15;182(10):6179-86
pubmed: 19414771
PLoS One. 2013 Dec 02;8(12):e81187
pubmed: 24312535
Int J Cardiol. 2015 Nov 15;199:451-9
pubmed: 26277551
Acta Trop. 2018 Aug;184:38-52
pubmed: 28941731
Circulation. 2007 Mar 6;115(9):1109-23
pubmed: 17339569
Mediators Inflamm. 2014;2014:912965
pubmed: 25104883
J Bioenerg Biomembr. 2008 Dec;40(6):587-98
pubmed: 19009337
Trends Parasitol. 2016 Nov;32(11):899-911
pubmed: 27612651
Infect Immun. 2007 Jul;75(7):3641-50
pubmed: 17485457
Int J Cardiol. 2007 Apr 4;116(3):357-63
pubmed: 16859784
Int J Cardiol. 1998 Sep 30;66(2):183-94
pubmed: 9829333
Clin Infect Dis. 2009 Sep 1;49(5):e52-4
pubmed: 19640226
Autoimmunity. 2001;34(3):187-92
pubmed: 11908776
Nature. 1992 Mar 26;356(6367):338-40
pubmed: 1549177
Clin Microbiol Rev. 2011 Jul;24(3):592-630
pubmed: 21734249
Front Microbiol. 2016 Jul 14;7:1076
pubmed: 27471496
PLoS Negl Trop Dis. 2011 Apr 26;5(4):e1136
pubmed: 21572510
PLoS One. 2012;7(1):e28449
pubmed: 22238578
Am J Pathol. 2005 Aug;167(2):305-13
pubmed: 16049318
Free Radic Biol Med. 2009 Nov 15;47(10):1414-21
pubmed: 19686837
PLoS Negl Trop Dis. 2014 Aug 21;8(8):e2989
pubmed: 25144227
Int Immunol. 2002 Mar;14(3):299-308
pubmed: 11867566
Mem Inst Oswaldo Cruz. 2018 Feb 19;113(4):e170440
pubmed: 29513876
Clin Diagn Lab Immunol. 2001 Jan;8(1):112-8
pubmed: 11139203
Infect Immun. 2003 Mar;71(3):1185-93
pubmed: 12595431
Clin Exp Immunol. 1982 Jun;48(3):754-7
pubmed: 6811174
Clin Infect Dis. 2012 Mar;54(6):845-52
pubmed: 22238161
BMC Infect Dis. 2013 Feb 13;13:85
pubmed: 23406191
Am J Pathol. 2014 Feb;184(2):494-506
pubmed: 24300951
Cell Microbiol. 2012 May;14(5):634-43
pubmed: 22309180
Rev Soc Bras Med Trop. 2013 Sep-Oct;46(5):536-41
pubmed: 23904079
Prog Cardiovasc Dis. 2009 May-Jun;51(6):524-39
pubmed: 19410685
Clin Dev Immunol. 2012;2012:361730
pubmed: 22811738
Am J Trop Med Hyg. 2015 Feb;92(2):325-30
pubmed: 25371187
Parasite Immunol. 1991 Jul;13(4):345-56
pubmed: 1717927
Trends Cardiovasc Med. 2012 Jul;22(5):113-7
pubmed: 22902177
Immunol Rev. 2015 May;265(1):156-71
pubmed: 25879291
Scand J Immunol. 2007 Aug-Sep;66(2-3):128-36
pubmed: 17635790
Adv Parasitol. 2011;76:101-27
pubmed: 21884889
Microbes Infect. 2008 May;10(6):680-8
pubmed: 18485782
J Am Coll Cardiol. 2010 Jun 1;55(22):2499-508
pubmed: 20510218
Cell Microbiol. 2016 Oct;18(10):1429-43
pubmed: 26918803
PLoS Negl Trop Dis. 2015 Jan 08;9(1):e3432
pubmed: 25569149
J Immunol. 1990 May 15;144(10):4000-4
pubmed: 2185317
J Infect Dis. 2017 Feb 1;215(3):387-395
pubmed: 28003350
Scand J Immunol. 2005 Sep;62(3):297-308
pubmed: 16179017
Trends Immunol. 2015 Mar;36(3):161-78
pubmed: 25687683
BMC Infect Dis. 2017 Mar 21;17(1):221
pubmed: 28327099
Curr Top Microbiol Immunol. 2005;296:89-123
pubmed: 16323421
Adv Immunol. 2017;136:29-84
pubmed: 28950949
Adv Parasitol. 2011;76:235-50
pubmed: 21884894
Infect Immun. 2007 Apr;75(4):1886-94
pubmed: 17283096
Clin Exp Immunol. 2006 Jul;145(1):81-92
pubmed: 16792677
J Immunol. 2017 Apr 15;198(8):3170-3180
pubmed: 28258194
PLoS Negl Trop Dis. 2016 Feb 25;10(2):e0004343
pubmed: 26913759
Parasite Immunol. 2009 Nov;31(11):673-85
pubmed: 19825107
Proc Natl Acad Sci U S A. 1986 Sep;83(17):6593-7
pubmed: 2944112
JACC Basic Transl Sci. 2016 Jun;1(4):235-250
pubmed: 27747306
Mem Inst Oswaldo Cruz. 2011 Feb;106(1):85-91
pubmed: 21340361
J Immunol. 1990 May 1;144(9):3558-62
pubmed: 2139458
PLoS Negl Trop Dis. 2017 Aug 7;11(8):e0005819
pubmed: 28787451
BMC Infect Dis. 2012 May 24;12:123
pubmed: 22625224
Mediators Inflamm. 2014;2014:893634
pubmed: 25165415
Annu Rev Microbiol. 1973;27:347-82
pubmed: 4201691
Trans R Soc Trop Med Hyg. 1993 Mar-Apr;87(2):220-3
pubmed: 8337734
PLoS Negl Trop Dis. 2016 Feb 26;10(2):e0004490
pubmed: 26919708
Antioxid Redox Signal. 2010 Jan;12(1):27-37
pubmed: 19624257
Front Biosci. 2003 Jan 01;8:e94-109
pubmed: 12456334
J Pathol. 2011 Dec;225(4):583-96
pubmed: 21952987
Sao Paulo Med J. 1995 Mar-Apr;113(2):757-66
pubmed: 8650474
Mediators Inflamm. 2004 Jun;13(3):139-43
pubmed: 15223603
PLoS Negl Trop Dis. 2011 Aug;5(8):e1294
pubmed: 21886854
Infect Immun. 1988 Apr;56(4):993-7
pubmed: 3126153
PLoS Negl Trop Dis. 2012;6(5):e1498
pubmed: 22666504
Cell Mol Life Sci. 2016 Aug;73(16):3035-51
pubmed: 27032699
Autoimmun Rev. 2011 Jan;10(3):163-5
pubmed: 20883825
J Am Heart Assoc. 2012 Dec;1(6):e003855
pubmed: 23316324
Transpl Infect Dis. 2017 Dec;19(6):
pubmed: 28945308
Ann Trop Med Parasitol. 2011 Jan;105(1):25-9
pubmed: 21294946
Exp Parasitol. 2011 Jan;127(1):58-65
pubmed: 20599987
Infect Immun. 2016 Mar 24;84(4):1123-1136
pubmed: 26857570
J Exp Med. 1994 Mar 1;179(3):1017-22
pubmed: 8113670
Exp Parasitol. 2009 Jan;121(1):8-14
pubmed: 18848935
J Nucl Med. 2011 Apr;52(4):504-10
pubmed: 21441532
Int J Parasitol. 2009 Nov;39(13):1455-64
pubmed: 19505468
PLoS Negl Trop Dis. 2018 Feb 9;12(2):e0006226
pubmed: 29425201
Parasite Immunol. 2013 Jan;35(1):1-10
pubmed: 23009341
Clin Infect Dis. 2017 May 1;64(9):1182-1188
pubmed: 28329123
J Am Med Assoc. 1955 Oct 15;159(7):676-7
pubmed: 13263111
Cell Microbiol. 2014 Sep;16(9):1285-300
pubmed: 24712539
Infect Immun. 2010 Feb;78(2):810-22
pubmed: 19917711
Arq Bras Cardiol. 1972 Feb;25(1):17-25
pubmed: 4626481
J Innate Immun. 2017;9(2):203-216
pubmed: 27902980
Microbes Infect. 2011 Nov;13(12-13):1002-5
pubmed: 21726660
Am J Trop Med Hyg. 2003 Feb;68(2):248-52
pubmed: 12641420
Int J Parasitol. 2003 Mar;33(3):293-9
pubmed: 12670514
Am J Pathol. 2012 Jul;181(1):130-40
pubmed: 22658486
J Biol Chem. 2011 Feb 25;286(8):6627-40
pubmed: 21098483
Int Immunol. 1994 Apr;6(4):499-506
pubmed: 8018591
PLoS Pathog. 2016 Oct 20;12(10):e1005954
pubmed: 27764247
Int J Cardiol. 1991 Mar;30(3):335-40
pubmed: 2055674
J Immunol. 1990 Jan 15;144(2):717-24
pubmed: 2104903
Am J Pathol. 2000 May;156(5):1805-9
pubmed: 10793092
Int J Parasitol. 2008 Oct;38(12):1391-400
pubmed: 18511053
Front Microbiol. 2018 Mar 06;9:269
pubmed: 29559958
Infect Immun. 2016 Nov 18;84(12):3527-3541
pubmed: 27698021
Mem Inst Oswaldo Cruz. 2017 Mar;112(3):224-235
pubmed: 28225900
Microbes Infect. 2008 Jun;10(7):825-33
pubmed: 18538611
Int Immunol. 2006 Mar;18(3):465-71
pubmed: 16431876
Front Immunol. 2017 Aug 02;8:840
pubmed: 28824610
Immunol Res. 2014 Aug;59(1-3):142-52
pubmed: 24989828
Microbes Infect. 2006 Aug;8(9-10):2459-64
pubmed: 16963301
Biochem J. 2008 Mar 1;410(2):359-68
pubmed: 17973627
J Vis Exp. 2012 Jul 29;(65):3716
pubmed: 22951533
Eur J Microbiol Immunol (Bp). 2014 Jun;4(2):128-37
pubmed: 24883199
Cardiol Clin. 2017 Feb;35(1):31-47
pubmed: 27886788
FEMS Microbiol Rev. 2012 May;36(3):734-47
pubmed: 22339763
Rev Soc Bras Med Trop. 1988 Jan-Mar;21(1):7-13
pubmed: 3231748
Histochem Cell Biol. 2014 Sep;142(3):235-44
pubmed: 25059649
Expert Rev Cardiovasc Ther. 2015 Dec;13(12):1393-409
pubmed: 26496376
Infect Immun. 2015 May;83(5):2099-108
pubmed: 25754197
Am J Trop Med Hyg. 1999 Aug;61(2):308-14
pubmed: 10463685
Front Microbiol. 2017 Apr 20;8:607
pubmed: 28473804
Clin Pharmacol Ther. 2012 Nov;92(5):613-21
pubmed: 22990752
Am J Clin Pathol. 2016 Aug;146(2):191-8
pubmed: 27425387
Clin Exp Immunol. 2001 May;124(2):266-73
pubmed: 11422204
Mediators Inflamm. 2012;2012:478601
pubmed: 22619483
Pathog Dis. 2015 Dec;73(9):ftv082
pubmed: 26438729
Vaccine. 2016 Jun 3;34(26):2996-3000
pubmed: 27026146
Parasitol Res. 2015 Mar;114(3):1167-78
pubmed: 25576191
N Engl J Med. 2015 Oct;373(14):1295-306
pubmed: 26323937
Microbes Infect. 2008 Aug-Sep;10(10-11):1201-9
pubmed: 18675934
Infect Immun. 1994 May;62(5):1820-9
pubmed: 8168945
Rev Inst Med Trop Sao Paulo. 1997 Jan-Feb;39(1):53-60
pubmed: 9394539
Cytokine. 2009 Mar;45(3):149-53
pubmed: 19136278
Infect Immun. 2004 Sep;72(9):5283-91
pubmed: 15322024
Clin Microbiol Rev. 1992 Oct;5(4):400-19
pubmed: 1423218
J Clin Invest. 1989 Dec;84(6):1982-9
pubmed: 2687332
Semin Immunopathol. 2012 Nov;34(6):753-70
pubmed: 23076807
Cell Cycle. 2011 Apr 1;10(7):1132-43
pubmed: 21364319
Infect Genet Evol. 2018 Mar;58:171-180
pubmed: 29269323
PLoS Pathog. 2016 Oct 3;12(10):e1005902
pubmed: 27695083
Am Heart J. 1996 Feb;131(2):417-20
pubmed: 8579048
Infect Genet Evol. 2012 Mar;12(2):240-53
pubmed: 22226704
PLoS Negl Trop Dis. 2012;6(4):e1630
pubmed: 22545173
J Biol Chem. 2010 Apr 9;285(15):11596-606
pubmed: 20145242
PLoS Negl Trop Dis. 2010 Feb 16;4(2):e604
pubmed: 20169058
Gene. 2008 Jan 31;408(1-2):45-50
pubmed: 18022330
Infect Immun. 2016 May 24;84(6):1842-1856
pubmed: 27068090
Gastroenterology. 2011 Jul;141(1):35-404
pubmed: 21640110
Trans R Soc Trop Med Hyg. 2013 Aug;107(8):518-25
pubmed: 23787193
Trop Med Int Health. 2016 Dec;21(12):1545-1551
pubmed: 27699992
Front Biosci (Elite Ed). 2012 Jan 01;4:1743-58
pubmed: 22201990
Antioxid Redox Signal. 2017 Sep 20;27(9):550-566
pubmed: 28132522
Scand J Immunol. 1997 Jan;45(1):74-80
pubmed: 9010503
Ann N Y Acad Sci. 2007 Jun;1107:434-44
pubmed: 17804572