Multimorbidity and functional impairment-bidirectional interplay, synergistic effects and common pathways.
ageing
cognitive function
multimorbidity
physical function
Journal
Journal of internal medicine
ISSN: 1365-2796
Titre abrégé: J Intern Med
Pays: England
ID NLM: 8904841
Informations de publication
Date de publication:
03 2019
03 2019
Historique:
pubmed:
26
10
2018
medline:
17
3
2020
entrez:
26
10
2018
Statut:
ppublish
Résumé
This review discusses the interplay between multimorbidity (i.e. co-occurrence of more than one chronic health condition in an individual) and functional impairment (i.e. limitations in mobility, strength or cognition that may eventually hamper a person's ability to perform everyday tasks). On the one hand, diseases belonging to common patterns of multimorbidity may interact, curtailing compensatory mechanisms and resulting in physical and cognitive decline. On the other hand, physical and cognitive impairment impact the severity and burden of multimorbidity, contributing to the establishment of a vicious circle. The circle may be further exacerbated by people's reduced ability to cope with treatment and care burden and physicians' fragmented view of health problems, which cause suboptimal use of health services and reduced quality of life and survival. Thus, the synergistic effects of medical diagnoses and functional status in adults, particularly older adults, emerge as central to assessing their health and care needs. Furthermore, common pathways seem to underlie multimorbidity, functional impairment and their interplay. For example, older age, obesity, involuntary weight loss and sedentarism can accelerate damage accumulation in organs and physiological systems by fostering inflammatory status. Inappropriate use or overuse of specific medications and drug-drug and drug-disease interactions also contribute to the bidirectional association between multimorbidity and functional impairment. Additionally, psychosocial factors such as low socioeconomic status and the direct or indirect effects of negative life events, weak social networks and an external locus of control may underlie the complex interactions between multimorbidity, functional decline and negative outcomes. Identifying modifiable risk factors and pathways common to multimorbidity and functional impairment could aid in the design of interventions to delay, prevent or alleviate age-related health deterioration; this review provides an overview of knowledge gaps and future directions.
Identifiants
pubmed: 30357990
doi: 10.1111/joim.12843
pmc: PMC6446236
mid: NIHMS1016084
doi:
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
255-271Subventions
Organisme : Intramural NIH HHS
ID : Z99 AG999999
Pays : United States
Informations de copyright
© 2018 The Association for the Publication of the Journal of Internal Medicine.
Références
JAMA. 2000 Jun 28;283(24):3230-5
pubmed: 10866871
J Gerontol A Biol Sci Med Sci. 2001 Mar;56(3):M146-56
pubmed: 11253156
J Psychosom Res. 2001 Feb;50(2):95-102
pubmed: 11274666
J Gerontol B Psychol Sci Soc Sci. 2002 May;57(3):S135-44
pubmed: 11983740
BMC Geriatr. 2003 Dec 19;3:7
pubmed: 14683526
J Clin Epidemiol. 2004 Jan;57(1):55-65
pubmed: 15019011
Health Qual Life Outcomes. 2004 Sep 07;2:47
pubmed: 15353000
Arch Intern Med. 2005 Apr 11;165(7):808-13
pubmed: 15824303
BMJ. 2005 Dec 17;331(7530):1462-4
pubmed: 16356984
Am J Geriatr Psychiatry. 2006 Jan;14(1):6-20
pubmed: 16407577
J Clin Epidemiol. 2006 Sep;59(9):934-9
pubmed: 16895816
J Gerontol A Biol Sci Med Sci. 2007 Mar;62(3):275-80
pubmed: 17389724
Med Care. 2008 Aug;46(8):839-46
pubmed: 18665064
J Gerontol A Biol Sci Med Sci. 2008 Jul;63(7):698-706
pubmed: 18693224
J Am Geriatr Soc. 2008 Dec;56(12):2171-9
pubmed: 19093915
J Intern Med. 2009 Feb;265(2):288-95
pubmed: 19192038
Br J Clin Pharmacol. 2009 Jun;67(6):641-5
pubmed: 19594531
Ann Fam Med. 2009 Jul-Aug;7(4):357-63
pubmed: 19597174
Am J Epidemiol. 2010 Sep 1;172(5):558-65
pubmed: 20682520
Int J Geriatr Psychiatry. 2011 Oct;26(10):1046-53
pubmed: 20963809
Soc Psychiatry Psychiatr Epidemiol. 2012 Feb;47(2):175-84
pubmed: 21184214
PLoS One. 2010 Dec 29;5(12):e15941
pubmed: 21209965
N Engl J Med. 2011 Mar 3;364(9):818-28
pubmed: 21366473
Ageing Res Rev. 2011 Sep;10(4):430-9
pubmed: 21402176
QJM. 2011 Nov;104(11):913-20
pubmed: 21768167
Am J Manag Care. 2011 Aug 01;17(8):e324-32
pubmed: 21851140
Dement Geriatr Cogn Disord. 2011;32(2):103-10
pubmed: 21952417
Am J Med. 2012 Jan;125(1):79-86
pubmed: 22195532
Age (Dordr). 2013 Jun;35(3):929-41
pubmed: 22314403
Ann Fam Med. 2012 Mar-Apr;10(2):142-51
pubmed: 22412006
Lancet. 2012 Jul 7;380(9836):37-43
pubmed: 22579043
J Psychosom Res. 2012 Sep;73(3):211-7
pubmed: 22850262
J Clin Epidemiol. 2012 Oct;65(10):1041-51
pubmed: 22910536
Aging Clin Exp Res. 2012 Oct;24(5):480-9
pubmed: 22961066
J Am Geriatr Soc. 2012 Sep;60(9):1624-31
pubmed: 22985138
CMAJ. 2013 Mar 19;185(5):E221-8
pubmed: 23422444
Int Psychogeriatr. 2013 Jul;25(7):1077-84
pubmed: 23575107
J Alzheimers Dis. 2013;36(2):275-84
pubmed: 23603395
J Gerontol A Biol Sci Med Sci. 2014 Apr;69(4):430-7
pubmed: 23913935
Int J Equity Health. 2013 Aug 20;12:67
pubmed: 23962150
Psychosom Med. 2013 Sep;75(7):616-23
pubmed: 23975946
BMC Geriatr. 2014 Jan 28;14:10
pubmed: 24472217
J Clin Epidemiol. 2014 Mar;67(3):244-6
pubmed: 24472294
BMC Psychiatry. 2014 Mar 20;14:84
pubmed: 24645776
Can Fam Physician. 2014 May;60(5):e272-80
pubmed: 24829022
JAMA. 2014 Jun 18;311(23):2387-96
pubmed: 24866862
BMC Geriatr. 2014 May 28;14:70
pubmed: 24884813
Br J Gen Pract. 2014 Jul;64(624):e440-7
pubmed: 24982497
Eur J Intern Med. 2014 Sep;25(7):610-6
pubmed: 24997486
J Am Geriatr Soc. 2014 Sep;62(9):1722-8
pubmed: 25039832
PLoS One. 2014 Jul 21;9(7):e102149
pubmed: 25048354
PLoS One. 2014 Jul 24;9(7):e103120
pubmed: 25058497
J Gerontol A Biol Sci Med Sci. 2015 Jan;70(1):63-70
pubmed: 25104822
Eur J Intern Med. 2014 Nov;25(9):843-6
pubmed: 25312593
BMC Med. 2014 Oct 31;12:192
pubmed: 25358236
PLoS One. 2014 Nov 06;9(11):e111498
pubmed: 25375890
BMC Public Health. 2014 Nov 17;14:1170
pubmed: 25404039
J Gerontol A Biol Sci Med Sci. 2015 Nov;70(11):1297-303
pubmed: 25409892
Nat Rev Cardiol. 2015 May;12(5):267-77
pubmed: 25583619
Med Care. 2015 Feb;53(2):207-13
pubmed: 25588136
Eur Respir J. 2015 Mar;45(3):790-806
pubmed: 25614163
BMJ Open. 2015 Feb 03;5(2):e006413
pubmed: 25649210
J Aging Health. 2015 Aug;27(5):843-63
pubmed: 25649677
PLoS One. 2015 Mar 03;10(3):e0120077
pubmed: 25734828
BMJ. 2015 Mar 11;350:h1059
pubmed: 25761379
Lancet. 2015 Jun 6;385(9984):2255-63
pubmed: 25771249
Fam Pract. 2015 Jun;32(3):269-75
pubmed: 25900675
Geriatr Gerontol Int. 2016 Mar;16(3):345-51
pubmed: 25907542
J Am Med Dir Assoc. 2015 Aug 1;16(8):640-7
pubmed: 25958334
JAMA. 2015 Jul 7;314(1):52-60
pubmed: 26151266
Age Ageing. 2015 Sep;44(5):810-6
pubmed: 26220988
BMC Med. 2015 Aug 03;13:178
pubmed: 26239481
Prev Med. 2015 Dec;81:54-7
pubmed: 26264252
Br J Psychiatry. 2016 Mar;208(3):245-51
pubmed: 26294364
J Am Geriatr Soc. 2015 Sep;63(9):1791-7
pubmed: 26311068
J Am Geriatr Soc. 2015 Sep;63(9):1783-90
pubmed: 26311270
J Alzheimers Dis. 2015;48(4):949-58
pubmed: 26402118
Health Qual Life Outcomes. 2015 Oct 15;13:168
pubmed: 26467295
JAMA. 2015 Nov 3;314(17):1818-31
pubmed: 26529160
Aging (Albany NY). 2015 Dec;7(12):1198-211
pubmed: 26684672
Am J Health Promot. 2017 Jul;31(4):274-277
pubmed: 26730562
J Am Med Dir Assoc. 2016 Apr 1;17(4):318-23
pubmed: 26778489
Int J Behav Nutr Phys Act. 2016 Jan 19;13:8
pubmed: 26785753
J Nutr Health Aging. 2016 Mar;20(3):275-9
pubmed: 26892576
J Gen Intern Med. 2016 Jun;31(6):630-7
pubmed: 26902246
Clin Physiol Funct Imaging. 2017 Nov;37(6):782-784
pubmed: 26915931
J Gerontol A Biol Sci Med Sci. 2016 Jun;71(6):823-30
pubmed: 26968451
Lancet Neurol. 2016 Apr;15(5):455-532
pubmed: 26987701
Chronic Illn. 2016 Dec;12(4):272-280
pubmed: 27068114
J Frailty Aging. 2012;1(3):123-7
pubmed: 27093200
Eur J Intern Med. 2016 Jun;31:35-40
pubmed: 27108239
J Am Geriatr Soc. 2016 May;64(5):965-72
pubmed: 27131225
Neurology. 2016 May 31;86(22):2077-84
pubmed: 27164657
JAMA. 2016 Jun 28;315(24):2673-82
pubmed: 27195814
J Frailty Aging. 2016;5(2):100-3
pubmed: 27224500
Cell Metab. 2016 Jun 14;23(6):1060-1065
pubmed: 27304507
BMC Med. 2016 Jun 22;14(1):88
pubmed: 27328975
Public Health. 2016 Oct;139:103-111
pubmed: 27340043
Ann Fam Med. 2016 Jul;14(4):337-43
pubmed: 27401421
J Eval Clin Pract. 2017 Feb;23(1):199-208
pubmed: 27421249
JAMA Cardiol. 2016 Aug 01;1(5):568-74
pubmed: 27439082
BMJ Open. 2016 Jul 25;6(7):e008281
pubmed: 27456324
J Gerontol A Biol Sci Med Sci. 2017 Apr 1;72(4):528-534
pubmed: 27470302
PLoS One. 2016 Aug 02;11(8):e0160264
pubmed: 27482903
Arch Gerontol Geriatr. 2016 Nov-Dec;67:130-8
pubmed: 27500661
Acta Psychiatr Scand. 2016 Nov;134(5):430-440
pubmed: 27586958
Prev Chronic Dis. 2016 Nov 03;13:E151
pubmed: 27809419
Exp Gerontol. 2017 Aug;94:46-51
pubmed: 27871822
Int J Epidemiol. 2016 Aug;45(4):1015-1019
pubmed: 27880694
Ann N Y Acad Sci. 2016 Dec;1386(1):30-44
pubmed: 27907230
Age Ageing. 2017 May 1;46(3):413-420
pubmed: 27932368
Mayo Clin Proc. 2017 Mar;92(3):376-382
pubmed: 28160946
Age Ageing. 2017 Jan 13;46(1):33-39
pubmed: 28181629
J Gerontol B Psychol Sci Soc Sci. 2018 Sep 20;73(7):1303-1314
pubmed: 28199711
PLoS Med. 2017 Mar 7;14(3):e1002249
pubmed: 28267802
BMJ Open. 2017 Mar 9;7(3):e012546
pubmed: 28279992
J Am Geriatr Soc. 2017 May;65(5):1056-1060
pubmed: 28306158
Scand J Med Sci Sports. 2018 Feb;28(2):604-612
pubmed: 28329413
J Gerontol A Biol Sci Med Sci. 2017 Aug 1;72(8):1123-1129
pubmed: 28329788
Biogerontology. 2017 Aug;18(4):549-559
pubmed: 28352958
BMJ Open. 2017 Apr 7;7(4):e013384
pubmed: 28389486
J Geriatr Phys Ther. 2019 Apr/Jun;42(2):E1-E6
pubmed: 28437317
PLoS One. 2017 May 4;12(5):e0177044
pubmed: 28472200
J Gerontol A Biol Sci Med Sci. 2018 Jan 16;73(2):204-210
pubmed: 28541396
Brain Sci. 2017 May 23;7(6):null
pubmed: 28545247
Clin Epidemiol. 2017 May 10;9:279-289
pubmed: 28546772
J Gerontol A Biol Sci Med Sci. 2018 Jan 16;73(2):225-232
pubmed: 28605457
JAMA. 2017 Jun 13;317(22):2327-2328
pubmed: 28609520
Lancet Public Health. 2017 May 19;2(6):e277-e285
pubmed: 28626830
J Gerontol A Biol Sci Med Sci. 2018 Sep 11;73(10):1343-1349
pubmed: 28645202
Lancet Oncol. 2017 Aug;18(8):e457-e471
pubmed: 28759385
Eur J Clin Pharmacol. 2017 Nov;73(11):1467-1474
pubmed: 28766100
CMAJ Open. 2017 Aug 14;5(3):E623-E631
pubmed: 28811281
BMC Med. 2017 Aug 24;15(1):152
pubmed: 28835246
J Am Geriatr Soc. 2017 Oct;65(10):2285-2289
pubmed: 28857119
J Nutr Health Aging. 2017;21(8):909-917
pubmed: 28972244
Age Ageing. 2017 Nov 1;46(6):882-888
pubmed: 28985248
J Comorb. 2011 Dec 27;1:11-18
pubmed: 29090132
J Am Med Dir Assoc. 2018 Apr;19(4):355-360.e1
pubmed: 29108888
Soc Sci Med. 2017 Dec;195:42-49
pubmed: 29132081
Curr Drug Metab. 2018;19(2):142-154
pubmed: 29219052
Best Pract Res Clin Rheumatol. 2017 Apr;31(2):129-144
pubmed: 29224692
Exp Gerontol. 2018 May;105:10-18
pubmed: 29275161
J Alzheimers Dis. 2018;61(3):1119-1128
pubmed: 29286925
J Gerontol A Biol Sci Med Sci. 2018 Oct 8;73(11):1538-1544
pubmed: 29346526
Age Ageing. 2018 May 1;47(3):374-380
pubmed: 29370339
J Intern Med. 2018 May;283(5):489-499
pubmed: 29415323
Aust N Z J Public Health. 2018 Apr;42(2):186-194
pubmed: 29442409
Maturitas. 2018 Mar;109:53-62
pubmed: 29452782
Ann Oncol. 2018 Feb 1;29(suppl_2):ii1-ii9
pubmed: 29506228
PLoS Med. 2018 Mar 6;15(3):e1002503
pubmed: 29509768
Eur J Intern Med. 2018 Oct;56:49-52
pubmed: 29526651
J Gerontol A Biol Sci Med Sci. 2019 Jan 16;74(2):226-232
pubmed: 29529179
J Am Geriatr Soc. 2018 Jul;66(6):1101-1107
pubmed: 29603724
J Alzheimers Dis. 2018;63(2):773-781
pubmed: 29660933
Aging (Albany NY). 2018 Apr 18;10(4):573-591
pubmed: 29676998
J Gerontol A Biol Sci Med Sci. 2018 May 3;:null
pubmed: 29726918
J Am Med Dir Assoc. 2018 Aug;19(8):710-713
pubmed: 29861194
Lancet. 2018 Jul 7;392(10141):41-50
pubmed: 29961638
Ann Fam Med. 2018 Jul;16(4):322-329
pubmed: 29987080
BMJ. 1997 Oct 25;315(7115):1096-9
pubmed: 9366745