Glucocorticoid activation by 11β-hydroxysteroid dehydrogenase enzymes in relation to inflammation and glycaemic control in chronic kidney disease: A cross-sectional study.
11-beta-Hydroxysteroid Dehydrogenases
/ metabolism
Aged
Blood Glucose
/ metabolism
C-Reactive Protein
/ metabolism
Cross-Sectional Studies
Diabetes Mellitus
Female
Glomerular Filtration Rate
Glucocorticoids
/ metabolism
Glycated Hemoglobin
/ analysis
Humans
Hydrocortisone
/ metabolism
Inflammation
/ etiology
Male
Middle Aged
Renal Insufficiency, Chronic
/ blood
Journal
Clinical endocrinology
ISSN: 1365-2265
Titre abrégé: Clin Endocrinol (Oxf)
Pays: England
ID NLM: 0346653
Informations de publication
Date de publication:
01 2019
01 2019
Historique:
received:
13
08
2018
revised:
02
10
2018
accepted:
22
10
2018
pubmed:
26
10
2018
medline:
18
3
2020
entrez:
26
10
2018
Statut:
ppublish
Résumé
Patients with chronic kidney disease (CKD) have dysregulated cortisol metabolism secondary to changes in 11β-hydroxysteroid dehydrogenase (11β-HSD) enzymes. The determinants of this and its clinical implications are poorly defined. We performed a cross-sectional study to characterize shifts in cortisol metabolism in relation to renal function, inflammation and glycaemic control. Systemic activation of cortisol by 11β-HSD was measured as the metabolite ratio (tetrahydrocortisol [THF]+5α-tetrahydrocortisol [5αTHF])/tetrahydrocortisone (THE) in urine. The cohort included 342 participants with a median age of 63 years, median estimated glomerular filtration rate (eGFR) of 28 mL/min/1.73 m In summary, glucocorticoid activation by 11β-HSD in our cohort comprising a spectrum of renal function was associated with inflammation and impaired glucose control.
Identifiants
pubmed: 30358903
doi: 10.1111/cen.13889
pmc: PMC6334281
doi:
Substances chimiques
Blood Glucose
0
Glucocorticoids
0
Glycated Hemoglobin A
0
hemoglobin A1c protein, human
0
C-Reactive Protein
9007-41-4
11-beta-Hydroxysteroid Dehydrogenases
EC 1.1.1.146
Hydrocortisone
WI4X0X7BPJ
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
241-249Subventions
Organisme : Department of Health
Pays : United Kingdom
Organisme : Arthritis Research UK
ID : 20843
Pays : United Kingdom
Organisme : Versus Arthritis
ID : 20843
Pays : United Kingdom
Organisme : Wellcome Trust
ID : 105479/Z/14/Z
Pays : United Kingdom
Organisme : Medical Research Council
ID : MR/P021220/1
Pays : United Kingdom
Informations de copyright
© 2018 The Authors. Clinical Endocrinology Published by John Wiley & Sons Ltd.
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