Effects of cigarette smoke on immunity, neuroinflammation and multiple sclerosis.
B cells
Multiple sclerosis
Neuroinflammation
Smoking
T cells
Journal
Journal of neuroimmunology
ISSN: 1872-8421
Titre abrégé: J Neuroimmunol
Pays: Netherlands
ID NLM: 8109498
Informations de publication
Date de publication:
15 04 2019
15 04 2019
Historique:
received:
18
03
2018
revised:
30
09
2018
accepted:
05
10
2018
pubmed:
27
10
2018
medline:
4
12
2019
entrez:
27
10
2018
Statut:
ppublish
Résumé
Cigarette smoking is the most prominent significant cause of death and morbidity. It is recognised as a risk factor for a number of immune mediated, inflammatory diseases including multiple sclerosis (MS). Here, we review the complex immunological effects of smoking on the immune system, which include enhancement of inflammatory responses with a parallel reduction of some immune defences, resulting in an increased susceptibility to infection and a persistent proinflammatory environment. We discuss the effect of smoking on the susceptibility, clinical course, disability, and mortality in MS, the likely benefits of smoking cessation, and the specific immunological effects of smoking in MS. In conclusion, smoking is an important environmental risk factor for MS occurrence and outcome, and it acts in significant part through immunological mechanisms.
Identifiants
pubmed: 30361070
pii: S0165-5728(18)30130-9
doi: 10.1016/j.jneuroim.2018.10.004
pii:
doi:
Substances chimiques
Inflammation Mediators
0
Tobacco Smoke Pollution
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
24-34Informations de copyright
Copyright © 2018. Published by Elsevier B.V.