IFITM proteins drive type 2 T helper cell differentiation and exacerbate allergic airway inflammation.

Animals Cell Differentiation / genetics Cells, Cultured Hypersensitivity / immunology Inflammation / immunology Interferon-gamma / metabolism Interleukin-27 / metabolism Interleukin-4 / metabolism Lymphocyte Activation / genetics Membrane Proteins / genetics Mice Mice, Inbred C57BL Mice, Knockout Respiratory System / immunology Th1 Cells / immunology Th1-Th2 Balance / genetics Th2 Cells / immunology
Allergic airway disease IFN-γ Interferon-inducible transmembrane (IFITM) protein T helper 1 (Th1) T helper 2 (Th2)

Journal

European journal of immunology
ISSN: 1521-4141
Titre abrégé: Eur J Immunol
Pays: Germany
ID NLM: 1273201

Informations de publication

Date de publication:
01 2019
Historique:
received: 10 05 2018
revised: 13 09 2018
accepted: 24 10 2018
pubmed: 27 10 2018
medline: 29 5 2019
entrez: 27 10 2018
Statut: ppublish

Résumé

The interferon-inducible transmembrane (Ifitm/Fragilis) genes encode homologous proteins that are induced by IFNs. Here, we show that IFITM proteins regulate murine CD4

Identifiants

DOI: 10.1002/eji.201847692 PMID: 30365177 PMC: PMC6396086
pubmed: 30365177
doi: 10.1002/eji.201847692
pmc: PMC6396086
doi:

Substances chimiques

Interleukin-27 0
Membrane Proteins 0
fragilis protein, mouse 0
fragilis3 protein, mouse 0
Interleukin-4 207137-56-2
Interferon-gamma 82115-62-6

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

66-78

Subventions

Organisme : Medical Research Council
ID : MR/P000843/1
Pays : United Kingdom
Organisme : Biotechnology and Biological Sciences Research Council
ID : BB/1026324/1
Pays : United Kingdom

Informations de copyright

© 2018 The Authors. European Journal of Immunology published by WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

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Auteurs

Diana C Yánez (DC)

UCL Great Ormond Street Institute of Child Health, London, UK.
School of Medicine, Universidad San Francisco de Quito, Quito, Ecuador.

Hemant Sahni (H)

UCL Great Ormond Street Institute of Child Health, London, UK.

Susan Ross (S)

UCL Great Ormond Street Institute of Child Health, London, UK.

Anisha Solanki (A)

UCL Great Ormond Street Institute of Child Health, London, UK.

Ching-In Lau (CI)

UCL Great Ormond Street Institute of Child Health, London, UK.

Eleftheria Papaioannou (E)

UCL Great Ormond Street Institute of Child Health, London, UK.

Alessandro Barbarulo (A)

UCL Great Ormond Street Institute of Child Health, London, UK.

Rebecca Powell (R)

UCL Great Ormond Street Institute of Child Health, London, UK.

Ulrike C Lange (UC)

Department of Anesthesiology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
The Wellcome Trust/Cancer Research UK Gurdon Institute, Cambridge, UK.

David J Adams (DJ)

Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Cambridge, UK.

Martino Barenco (M)

UCL Great Ormond Street Institute of Child Health, London, UK.

Masahiro Ono (M)

UCL Great Ormond Street Institute of Child Health, London, UK.
Department of Life Sciences, Sir Alexander Fleming Building, Imperial College London, London, UK.

Fulvio D'Acquisto (F)

Health Science Research Centre, University of Roehampton, London, UK.

Anna L Furmanski (AL)

UCL Great Ormond Street Institute of Child Health, London, UK.
School of Life Sciences, University of Bedfordshire, Luton, UK.

Tessa Crompton (T)

UCL Great Ormond Street Institute of Child Health, London, UK.
ORCID: 0000-0002-8973-4021

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › IFITM proteins drive type 2 T helper cell...
questionsmedicales.fr › Phénomènes physiologiques cellulaires › Différenciation cellulaire › IFITM proteins drive type 2 T helper cell...
questionsmedicales.fr › Cellules › Cellules cultivées › IFITM proteins drive type 2 T helper cell...
questionsmedicales.fr › Maladies du système immunitaire › Hypersensibilité › IFITM proteins drive type 2 T helper cell...
questionsmedicales.fr › États, signes et symptômes pathologiques › Processus pathologiques › Inflammation › IFITM proteins drive type 2 T helper cell...
questionsmedicales.fr › Facteurs biologiques › Protéines et peptides de signalisation intercellulaire › Cytokines › Lymphokines › Facteurs d'activation des macrophages › Interféron gamma › IFITM proteins drive type 2 T helper cell...
questionsmedicales.fr › Facteurs biologiques › Protéines et peptides de signalisation intercellulaire › Cytokines › Interleukines › Interleukine-27 › IFITM proteins drive type 2 T helper cell...
questionsmedicales.fr › Facteurs biologiques › Protéines et peptides de signalisation intercellulaire › Cytokines › Interleukines › Interleukine-4 › IFITM proteins drive type 2 T helper cell...
questionsmedicales.fr › Phénomènes du système immunitaire › Activation des lymphocytes › IFITM proteins drive type 2 T helper cell...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › IFITM proteins drive type 2 T helper cell...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › IFITM proteins drive type 2 T helper cell...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Lignées consanguines de souris › Souris de lignée C57BL › IFITM proteins drive type 2 T helper cell...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Souris transgéniques › Souris knockout › IFITM proteins drive type 2 T helper cell...
questionsmedicales.fr › Appareil respiratoire › IFITM proteins drive type 2 T helper cell...
questionsmedicales.fr › Systèmes sanguin et immunitaire › Système immunitaire › Leucocytes › Agranulocytes › Lymphocytes › Lymphocytes T › Sous-populations de lymphocytes T › Lymphocytes T auxiliaires › Lymphocytes auxiliaires Th1 › IFITM proteins drive type 2 T helper cell...
questionsmedicales.fr › Phénomènes du système immunitaire › Équilibre Th1-Th2 › IFITM proteins drive type 2 T helper cell...
questionsmedicales.fr › Systèmes sanguin et immunitaire › Système immunitaire › Leucocytes › Agranulocytes › Lymphocytes › Lymphocytes T › Sous-populations de lymphocytes T › Lymphocytes T auxiliaires › Lymphocytes auxiliaires Th2 › IFITM proteins drive type 2 T helper cell...