Corticospinal tract degeneration in ALS unmasked in T1-weighted images using texture analysis.
Adult
Aged
Amyotrophic Lateral Sclerosis
/ diagnostic imaging
Diffusion Tensor Imaging
/ methods
Female
Humans
Image Interpretation, Computer-Assisted
/ methods
Imaging, Three-Dimensional
/ methods
Magnetic Resonance Imaging
/ methods
Male
Middle Aged
Nerve Degeneration
/ diagnostic imaging
Neuroimaging
/ methods
Pyramidal Tracts
/ diagnostic imaging
adult
amyotrophic lateral sclerosis
corticospinal tracts
female
humans
magnetic resonance imaging
male
validation studies
Journal
Human brain mapping
ISSN: 1097-0193
Titre abrégé: Hum Brain Mapp
Pays: United States
ID NLM: 9419065
Informations de publication
Date de publication:
03 2019
03 2019
Historique:
received:
26
07
2018
revised:
20
09
2018
accepted:
12
10
2018
pubmed:
28
10
2018
medline:
9
4
2020
entrez:
28
10
2018
Statut:
ppublish
Résumé
The purpose of this study was to investigate whether textures computed from T1-weighted (T1W) images of the corticospinal tract (CST) in amyotrophic lateral sclerosis (ALS) are associated with degenerative changes evaluated by diffusion tensor imaging (DTI). Nineteen patients with ALS and 14 controls were prospectively recruited and underwent T1W and diffusion-weighted magnetic resonance imaging. Three-dimensional texture maps were computed from T1W images and correlated with the DTI metrics within the CST. Significantly correlated textures were selected and compared within the CST for group differences between patients and controls using voxel-wise analysis. Textures were correlated with the patients' clinical upper motor neuron (UMN) signs and their diagnostic accuracy was evaluated. Voxel-wise analysis of textures and their diagnostic performance were then assessed in an independent cohort with 26 patients and 13 controls. Results showed that textures autocorrelation, energy, and inverse difference normalized significantly correlated with DTI metrics (p < .05) and these textures were selected for further analyses. The textures demonstrated significant voxel-wise differences between patients and controls in the centrum semiovale and the posterior limb of the internal capsule bilaterally (p < .05). Autocorrelation and energy significantly correlated with UMN burden in patients (p < .05) and classified patients and controls with 97% accuracy (100% sensitivity, 92.9% specificity). In the independent cohort, the selected textures demonstrated similar regional differences between patients and controls and classified participants with 94.9% accuracy. These results provide evidence that T1-based textures are associated with degenerative changes in the CST.
Identifiants
pubmed: 30367724
doi: 10.1002/hbm.24437
pmc: PMC6865626
doi:
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
1174-1183Subventions
Organisme : Brain Canada
Pays : International
Organisme : CIHR
Pays : Canada
Organisme : ALS Society of Canada
Pays : International
Organisme : ALS Association
Pays : International
Informations de copyright
© 2018 Wiley Periodicals, Inc.
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