Equations to estimate prednisone dose using body weight.
Age Factors
Body Surface Area
Body Weight
Child
Child, Preschool
Drug Dosage Calculations
Female
Glucocorticoids
/ administration & dosage
Humans
Male
Models, Biological
Nephrotic Syndrome
/ drug therapy
Prednisone
/ administration & dosage
Prospective Studies
Randomized Controlled Trials as Topic
Reproducibility of Results
Body surface area
Idiopathic nephrotic syndrome
Journal
Pediatric nephrology (Berlin, Germany)
ISSN: 1432-198X
Titre abrégé: Pediatr Nephrol
Pays: Germany
ID NLM: 8708728
Informations de publication
Date de publication:
04 2019
04 2019
Historique:
received:
19
07
2018
accepted:
19
10
2018
revised:
14
10
2018
pubmed:
29
10
2018
medline:
28
4
2020
entrez:
29
10
2018
Statut:
ppublish
Résumé
In the clinical practice, prednisone (PDN) dose in children is often prescribed using the patient weight, despite dose calculation using body surface area (BSA) is assumed to be preferable, because it parallels better with PDN metabolism in human subjects. Calculations based on body weight (W) carry the risk of underdosing, particularly in young children. Conversely, BSA estimation requires knowing the patient height, which is not always available, and more complex calculations. To overcome these limitations, we have developed linear equations allowing approximating the BSA-based dose using only the patient weight in kilogram. To this end, we have used anthropomorphic data from 754 pediatric patients and have validated the proposed equations with a prospective cohort of 77 children with steroid sensitive nephrotic syndrome. The equation estimating a dose of 60 mg/m Both equations performed very well and predicted reliably the BSA-based dose with an average error of 3.4% and 2.2%, respectively.
Sections du résumé
BACKGROUND
In the clinical practice, prednisone (PDN) dose in children is often prescribed using the patient weight, despite dose calculation using body surface area (BSA) is assumed to be preferable, because it parallels better with PDN metabolism in human subjects.
METHODS
Calculations based on body weight (W) carry the risk of underdosing, particularly in young children. Conversely, BSA estimation requires knowing the patient height, which is not always available, and more complex calculations.
RESULTS
To overcome these limitations, we have developed linear equations allowing approximating the BSA-based dose using only the patient weight in kilogram. To this end, we have used anthropomorphic data from 754 pediatric patients and have validated the proposed equations with a prospective cohort of 77 children with steroid sensitive nephrotic syndrome. The equation estimating a dose of 60 mg/m
CONCLUSIONS
Both equations performed very well and predicted reliably the BSA-based dose with an average error of 3.4% and 2.2%, respectively.
Identifiants
pubmed: 30368613
doi: 10.1007/s00467-018-4127-8
pii: 10.1007/s00467-018-4127-8
doi:
Substances chimiques
Glucocorticoids
0
Prednisone
VB0R961HZT
Types de publication
Comparative Study
Journal Article
Validation Study
Langues
eng
Sous-ensembles de citation
IM
Pagination
685-688Références
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